CellMLPhysiome: G - S

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G


guyton_electrolytes_2008 @ v0.0.1

Guyton, Electrolytes, 2008

nothing

Parameters:

Name Description
Z 1.0
MDFL1 10.0
POK 0.1
MDFLKM 0.667
AMM1LM 0.005
VV9 2.51
VUD 0.000989
KORREN 0.0
ANGKNS 0.0
AURG 1.0
TVD 0.000980838
ANMALD 2.5
DTKA_init 0.0367573
AUTOGN 7.0
ALDMM 2.5
TRPL 0.0
TSSLML 0.15
POM 0.04
EARK 1.0
SR 1.0
ANMAM 1.4
RFCDFT 0.0
STH 0.977181
ANMLL 0.7
ANPXUL 10.0
O2VAD1_init 2.368e-7
VID1 0.01
RFABDP 1.0
TVD_init 0.000980838
ADHVUL 2.5
PCE 1.0
ANMTM 1.5
VTSF 6.0
RCDFPC 0.0
ANMNAM 1.0
AUY 0.0
RNAULL 0.3
HM8 4.714e-8
PM5 30.0
RNAUAD 0.0
PAEX 2.0
ANPC_init 1.0
CPPD 31.9719
OMM 57.1
EXCXP 1.0
HMD1_init 1.0
RFABX 0.8
VIC_init 25.0404
AMM2_init 1.09071
KORTC 10000.0
GPPD 1.0
AUS 1.0
AUX 1.0
PO2AMB 150.0
AMNAM 0.8
AHMNAR 0.3
ANMEM 1.6
VNTSTM 1.0
KORNER 0.0
ADHC_init 1.0
Z14 5.0
HMK 90.0
AULPM 0.0
VPTISS 0.0175
Z12 5.0
AMC_init 1.0
AMNAUL 15.0
Z5 0.3
ADHPUL 85.0
CPR 40.0
VPF1_init 0.0123238
TRNSFS 0.0
TSSLTC 0.005
AUM1 3.0
AUMAX 5.0
RVSM 1.0
RABSC 0.5
RFABKM 0.03
QAOLM 0.2
GLPCA 1.0
AR3T_init 1.1448
TIMETR 0.0
AUM2 1.0
GFNDMP 3.0
VRA1_init 0.100043
X 4.0
AU6_init 1.00132
AH11 1000.0
RAPRSP 0.0
RMULT1 1.0
RNAUGN 0.6
CFC 0.01167
CV 0.1
ANULL 0.8
AR1T_init 1.02127
KID 0.08
CMPTSS 2.0
PON 0.1
AR2T_init 1.01179
ADHKUL 5.0
EARLL 24.0
PA4 1.0
DTNARL 1.0e-6
AH10 0.333
QRF 0.15
AMM4 0.005
DIURET 1.0
KTOT_init 3622.54
HKM 0.53333
SR2 1.0
SRK 5.0
MDFLW2 0.005
POM2 2.0
Z4 0.5
LPPR 0.03
RAM 96.3
CNR 139.0
Z6 20.0
ANUM 6.0
A3K 40000.0
PGHF -2.0
A4K 0.1
KOD 0.0804374
ANPXAF 1.5
ALCLK 0.3
ATRFBM 0.0
A4K2 40000.0
Z18 5.0
AUN1 0.5
ANY -0.2
URFORM 0.24
MDFLWX 0.01
QOM1_init 48.0839
VP_init 3.00449
AUV 0.55
REK 1.0
ANXM 0.0
VVS1_init 3.28246
OVA_init 204.497
VV6_init 0.0101913
AUTOSN 0.9
RNAUUL 10.0
HPL_init 1.00163
AARLL 4.0
ANPKNS 0.0
RVRS 19.167
ARF 0.5
STA 0.0
VP1 0.01
U 4.0
VRC_init 2.00439
A2K 60.0
TVDDL 30.0
VTW_init 39.8952
DTNAR 0.675
AHTHM 2.0
AMT 60.0
TRRBC 0.0
AMCSNS 0.65
KORGN 1.0
Z10 45.0
ANUVM 0.0
HM6 1850.0
AM1LL 0.0
OVS_init 0.699673
AHY_init 0.301963
ADHKLL 0.2
AUK 0.004
SRK2 10000.0
PXTP 8.0
VAS1_init 0.862514
PL2 1.8
CPK 0.000253
AM1UL 5.0
EXCML 0.01
AMNALL 0.04
BAROTC 0.16
AUL 1.5
RTSPRS 6.0
HPR_init 1.00237
Z7 5.0
HSR 1.0
AU4_init -0.060024
ANT 12.0
RKC 5.8e-6
FIS 0.0
EXC 1.0
PO2ADV 0.001
A1K 0.5
ANV 5000.0
PRP_init 216.243
RNAGTC 15.0
LPDE 8.0
AH9 1.0
ANCSNS 0.4
EXE 0.0
PK2 0.79167
ANC_init 0.859476
Z19 5.0
POR 35.0
VTS2_init 0.0
QO2T_init 72.2362
VLA1_init 0.379883
HTAUML 0.4
VIDML 0.01
ANMKEL 0.3
NID 0.1
AU1_init 1.00007
PR1LL 0.0
Z11 0.01
CRRFLX 0.0
TENSGN 0.0
TENSTC 0.05
ANMUL 1.8
RAR 30.52
CKEEX 4.0
ATRVM 0.0
ANX1_init 0.0
VPA1_init 0.38131
EFAFR 0.0
ANPTC 4.0
ADHPAM 0.3
DR 0.0
PAR1_init 103.525
HYL 60.0
GBL 0.0
AMK 1.037
PLUR_init 159.549
AR1LM 0.005
ADHVLL 0.93617
GFLC 0.0208333
AUMIN 0.4
NAE_init 2109.91
AR2LM 0.005
DHDTR 0.05
HSL 1.0
PCR 15.0
PPR1_init 0.419998
ANMARL 0.86
AARK 1.0
ADHTC 15.0
O2CHMO 0.01
LPK 2.728e-14
CPF 0.0003
EXCXP2 0.17
PC_init 16.9144
OSV_init 0.694163
TSP_init 279.945
Z13 0.625
GFNLL 0.001
RNAUG3_init 0.0
AUMK1 0.3
AMKM 0.5
MDMP 0.0
ADHINF 0.0
AUC1 0.3
CN7 0.2
RFABDM 0.3
ANPINF 0.0
CN2 0.0212
AMM1T_init 1.00269
RCDFDP 2000.0
GCOPF 0.8092
O2A 0.1
PLDF 4.2
ALDINF 0.0
NOD 0.0959449
VV7_init 0.00366525
RPS 0.0
Z16 5.0
ALDKNS 0.0
ANMSLT 2.0
RTPPR 0.9
AUDMP 0.3
ANMKEM 2.0
O2M 164.0
RTPPRS 15.2
POZ 2.0
RFN 1.22057
ANGINF 0.0
AMKMUL 12.0
AUSLP 1.5
AUTO 0.0

States:

Name Description
VTW(time) 39.8952
NAE(time) 2109.91
KTOT(time) 3622.54
VIC(time) 25.0404

Observables: none

guyton_heart_hypertrophy_or_deterioration_2008 @ v0.0.1

Guyton, Heart Hypertrophy or Deterioration, 2008

nothing

Parameters:

Name Description
Z 1.0
MDFL1 10.0
POK 0.1
MDFLKM 0.667
AMM1LM 0.005
VV9 2.51
KORREN 0.0
ANGKNS 0.0
AURG 1.0
ANMALD 2.5
DTKA_init 0.0367573
AUTOGN 7.0
ALDMM 2.5
TRPL 0.0
TSSLML 0.15
POM 0.04
EARK 1.0
SR 1.0
ANMAM 1.4
RFCDFT 0.0
ANMLL 0.7
ANPXUL 10.0
O2VAD1_init 2.368e-7
VID1 0.01
RFABDP 1.0
TVD_init 0.000980838
ADHVUL 2.5
PCE 1.0
ANMTM 1.5
VTSF 6.0
RCDFPC 0.0
ANMNAM 1.0
AUY 0.0
RNAULL 0.3
HM8 4.714e-8
PM5 30.0
RNAUAD 0.0
PAEX 2.0
ANPC_init 1.0
CPPD 31.9719
OMM 57.1
EXCXP 1.0
HMD1_init 1.0
RFABX 0.8
VIC_init 25.0404
AMM2_init 1.09071
KORTC 10000.0
GPPD 1.0
AUS 1.0
AUX 1.0
PO2AMB 150.0
AMNAM 0.8
AHMNAR 0.3
ANMEM 1.6
VNTSTM 1.0
KORNER 0.0
ADHC_init 1.0
Z14 5.0
HMK 90.0
AULPM 0.0
VPTISS 0.0175
Z12 5.0
AMC_init 1.0
AMNAUL 15.0
Z5 0.3
ADHPUL 85.0
CPR 40.0
VPF1_init 0.0123238
TRNSFS 0.0
TSSLTC 0.005
AUM1 3.0
AUMAX 5.0
RVSM 1.0
RABSC 0.5
RFABKM 0.03
QAOLM 0.2
GLPCA 1.0
AR3T_init 1.1448
TIMETR 0.0
AUM2 1.0
GFNDMP 3.0
VRA1_init 0.100043
X 4.0
AU6_init 1.00132
AH11 1000.0
RAPRSP 0.0
RMULT1 1.0
RNAUGN 0.6
CFC 0.01167
CV 0.1
ANULL 0.8
AR1T_init 1.02127
KID 0.08
CMPTSS 2.0
PON 0.1
AR2T_init 1.01179
ADHKUL 5.0
EARLL 24.0
PA4 1.0
DTNARL 1.0e-6
AH10 0.333
QRF 0.15
AMM4 0.005
DIURET 1.0
KTOT_init 3622.54
HKM 0.53333
SR2 1.0
SRK 5.0
MDFLW2 0.005
POM2 2.0
Z4 0.5
LPPR 0.03
RAM 96.3
CNR 139.0
Z6 20.0
ANUM 6.0
A3K 40000.0
PGHF -2.0
PPA 15.6376
A4K 0.1
PA 103.525
ANPXAF 1.5
ALCLK 0.3
ATRFBM 0.0
A4K2 40000.0
Z18 5.0
AUN1 0.5
ANY -0.2
URFORM 0.24
MDFLWX 0.01
QOM1_init 48.0839
VP_init 3.00449
AUV 0.55
REK 1.0
ANXM 0.0
VVS1_init 3.28246
OVA_init 204.497
VV6_init 0.0101913
AUTOSN 0.9
RNAUUL 10.0
HPL_init 1.00163
AARLL 4.0
ANPKNS 0.0
RVRS 19.167
ARF 0.5
STA 0.0
VP1 0.01
U 4.0
VRC_init 2.00439
A2K 60.0
TVDDL 30.0
VTW_init 39.8952
DTNAR 0.675
AHTHM 2.0
AMCSNS 0.65
TRRBC 0.0
AMT 60.0
KORGN 1.0
Z10 45.0
ANUVM 0.0
HM6 1850.0
AM1LL 0.0
OVS_init 0.699673
AHY_init 0.301963
ADHKLL 0.2
AUK 0.004
SRK2 10000.0
PXTP 8.0
VAS1_init 0.862514
PL2 1.8
CPK 0.000253
AM1UL 5.0
EXCML 0.01
AMNALL 0.04
BAROTC 0.16
AUL 1.5
RTSPRS 6.0
HPR_init 1.00237
Z7 5.0
HSR 1.0
QAO 5.00707
AU4_init -0.060024
ANT 12.0
RKC 5.8e-6
FIS 0.0
EXC 1.0
PO2ADV 0.001
A1K 0.5
ANV 5000.0
PRP_init 216.243
RNAGTC 15.0
LPDE 8.0
AH9 1.0
ANCSNS 0.4
EXE 0.0
PK2 0.79167
ANC_init 0.859476
Z19 5.0
POR 35.0
VTS2_init 0.0
QO2T_init 72.2362
VLA1_init 0.379883
HTAUML 0.4
VIDML 0.01
ANMKEL 0.3
NID 0.1
AU1_init 1.00007
PR1LL 0.0
Z11 0.01
CRRFLX 0.0
TENSGN 0.0
TENSTC 0.05
ANMUL 1.8
RAR 30.52
CKEEX 4.0
ATRVM 0.0
ANX1_init 0.0
VPA1_init 0.38131
EFAFR 0.0
POT 35.1148
ADHPAM 0.3
DR 0.0
PAR1_init 103.525
HYL 60.0
GBL 0.0
PLUR_init 159.549
ANPTC 4.0
AR1LM 0.005
ADHVLL 0.93617
GFLC 0.0208333
AUMIN 0.4
NAE_init 2109.91
AR2LM 0.005
DHDTR 0.05
HSL 1.0
PCR 15.0
PPR1_init 0.419998
ANMARL 0.86
AARK 1.0
ADHTC 15.0
O2CHMO 0.01
LPK 2.728e-14
CPF 0.0003
EXCXP2 0.17
PC_init 16.9144
OSV_init 0.694163
TSP_init 279.945
Z13 0.625
GFNLL 0.001
RNAUG3_init 0.0
AUMK1 0.3
AMKM 0.5
MDMP 0.0
ADHINF 0.0
AUC1 0.3
CN7 0.2
RFABDM 0.3
ANPINF 0.0
CN2 0.0212
AMM1T_init 1.00269
RCDFDP 2000.0
GCOPF 0.8092
O2A 0.1
PLDF 4.2
ALDINF 0.0
VV7_init 0.00366525
RPS 0.0
Z16 5.0
ALDKNS 0.0
ANMSLT 2.0
RTPPR 0.9
AUDMP 0.3
ANMKEM 2.0
O2M 164.0
RTPPRS 15.2
POZ 2.0
RFN 1.22057
ANGINF 0.0
AMKMUL 12.0
AUSLP 1.5
AUTO 0.0

States:

Name Description
HMD1(time) 1.0
HPL(time) 1.00163
HPR(time) 1.00237

Observables: none

guyton_heart_rate_and_stroke_volume_2008 @ v0.0.1

Guyton, Heart, Rate, And, Stroke, Volume, 2008

nothing

Parameters: none

States: none

Observables: none

guyton_kidney_2008 @ v0.0.1

Guyton, Kidney, 2008

nothing

Parameters:

Name Description
Z 1.0
MDFL1 10.0
POK 0.1
MDFLKM 0.667
AMM1LM 0.005
VV9 2.51
KORREN 0.0
ANGKNS 0.0
AURG 1.0
ANMALD 2.5
DTKA_init 0.0367573
AUTOGN 7.0
ALDMM 2.5
TRPL 0.0
TSSLML 0.15
POM 0.04
EARK 1.0
AUM 1.00066
SR 1.0
ANMAM 1.4
RFCDFT 0.0
ANMLL 0.7
ANPXUL 10.0
O2VAD1_init 2.368e-7
VID1 0.01
RFABDP 1.0
TVD_init 0.000980838
CNA 142.035
ADHVUL 2.5
PCE 1.0
ANMTM 1.5
VTSF 6.0
RCDFPC 0.0
ANMNAM 1.0
AUY 0.0
RNAULL 0.3
HM8 4.714e-8
PM5 30.0
RNAUAD 0.0
PAEX 2.0
ANPC_init 1.0
CPPD 31.9719
OMM 57.1
EXCXP 1.0
HMD1_init 1.0
ANPX 1.0
RFABX 0.8
VIC_init 25.0404
AMM2_init 1.09071
KORTC 10000.0
GPPD 1.0
AUS 1.0
AUX 1.0
PO2AMB 150.0
AMNAM 0.8
AHMNAR 0.3
ANMEM 1.6
VNTSTM 1.0
KORNER 0.0
ADHC_init 1.0
Z14 5.0
HMK 90.0
AULPM 0.0
VPTISS 0.0175
Z12 5.0
AMC_init 1.0
AMNAUL 15.0
Z5 0.3
ADHPUL 85.0
CPR 40.0
HM1 0.39984739
VPF1_init 0.0123238
TRNSFS 0.0
TSSLTC 0.005
AUM1 3.0
AUMAX 5.0
RVSM 1.0
RABSC 0.5
RFABKM 0.03
GLPCA 1.0
QAOLM 0.2
AR3T_init 1.1448
TIMETR 0.0
AUM2 1.0
GFNDMP 3.0
VRA1_init 0.100043
X 4.0
AU6_init 1.00132
AH11 1000.0
RAPRSP 0.0
RMULT1 1.0
RNAUGN 0.6
CFC 0.01167
CV 0.1
ANULL 0.8
PAMKRN 1.0
KID 0.08
AR1T_init 1.02127
CMPTSS 2.0
PON 0.1
AR2T_init 1.01179
ADHKUL 5.0
PPC 29.9941
EARLL 24.0
PA4 1.0
DTNARL 1.0e-6
AH10 0.333
QRF 0.15
AMNA 1.0
DIURET 1.0
KTOT_init 3622.54
AMM4 0.005
HKM 0.53333
SR2 1.0
SRK 5.0
MDFLW2 0.005
POM2 2.0
Z4 0.5
LPPR 0.03
RAM 96.3
CNR 139.0
Z6 20.0
ANUM 6.0
A3K 40000.0
PGHF -2.0
A4K 0.1
PA 103.525
ANPXAF 1.5
ALCLK 0.3
ATRFBM 0.0
A4K2 40000.0
Z18 5.0
AUN1 0.5
ANY -0.2
URFORM 0.24
MDFLWX 0.01
QOM1_init 48.0839
VP_init 3.00449
AUV 0.55
REK 1.0
ANXM 0.0
VVS1_init 3.28246
OVA_init 204.497
VV6_init 0.0101913
VTW 39.8952
AUTOSN 0.9
RNAUUL 10.0
HPL_init 1.00163
AARLL 4.0
ANPKNS 0.0
RVRS 19.167
ARF 0.5
STA 0.0
VP1 0.01
U 4.0
VRC_init 2.00439
A2K 60.0
TVDDL 30.0
VTW_init 39.8952
DTNAR 0.675
AHTHM 2.0
AMCSNS 0.65
TRRBC 0.0
AMT 60.0
KORGN 1.0
Z10 45.0
ANUVM 0.0
HM6 1850.0
AM1LL 0.0
OVS_init 0.699673
AHY_init 0.301963
ADHKLL 0.2
AUK 0.004
SRK2 10000.0
ANM 0.987545
PXTP 8.0
ADHMK 1.0
VAS1_init 0.862514
PL2 1.8
CPK 0.000253
AM1UL 5.0
EXCML 0.01
AMNALL 0.04
BAROTC 0.16
AUL 1.5
RTSPRS 6.0
HPR_init 1.00237
Z7 5.0
HSR 1.0
AU4_init -0.060024
ANT 12.0
RKC 5.8e-6
FIS 0.0
EXC 1.0
PO2ADV 0.001
A1K 0.5
ANV 5000.0
PRP_init 216.243
RNAGTC 15.0
LPDE 8.0
MYOGRS 1.0
AH9 1.0
ANCSNS 0.4
EXE 0.0
PK2 0.79167
ANC_init 0.859476
Z19 5.0
POR 35.0
VTS2_init 0.0
QO2T_init 72.2362
VLA1_init 0.379883
HTAUML 0.4
VIDML 0.01
ANMKEL 0.3
NID 0.1
AU1_init 1.00007
PR1LL 0.0
Z11 0.01
CRRFLX 0.0
TENSGN 0.0
CKE 4.44092
ANMUL 1.8
TENSTC 0.05
CKEEX 4.0
ATRVM 0.0
RAR 30.52
ANX1_init 0.0
EFAFR 0.0
VPA1_init 0.38131
PAR1_init 103.525
PLUR_init 159.549
ADHPAM 0.3
DR 0.0
GBL 0.0
AMK 1.037
HYL 60.0
ANPTC 4.0
AR1LM 0.005
ADHVLL 0.93617
GFLC 0.0208333
AUMIN 0.4
NAE_init 2109.91
AR2LM 0.005
DHDTR 0.05
HSL 1.0
PCR 15.0
PPR1_init 0.419998
ANMARL 0.86
AARK 1.0
ADHTC 15.0
O2CHMO 0.01
LPK 2.728e-14
CPF 0.0003
EXCXP2 0.17
PC_init 16.9144
OSV_init 0.694163
TSP_init 279.945
Z13 0.625
GFNLL 0.001
RNAUG3_init 0.0
AUMK1 0.3
AMKM 0.5
MDMP 0.0
ADHINF 0.0
AUC1 0.3
RFABDM 0.3
CN7 0.2
ANPINF 0.0
CN2 0.0212
AMM1T_init 1.00269
RCDFDP 2000.0
GCOPF 0.8092
O2A 0.1
PLDF 4.2
ALDINF 0.0
VV7_init 0.00366525
RPS 0.0
Z16 5.0
ALDKNS 0.0
ANMSLT 2.0
RTPPR 0.9
AUDMP 0.3
ANMKEM 2.0
O2M 164.0
RTPPRS 15.2
POZ 2.0
RFN 1.22057
ANGINF 0.0
AMKMUL 12.0
AUSLP 1.5
AUTO 0.0

States:

Name Description
RNAUG3(time) nothing
PLUR(time) nothing
PAR1(time) nothing
PFL(time) nothing
RNAUG4(time) nothing
DTKA(time) nothing
RR(time) nothing
PTFL(time) nothing

Observables: none

guyton_muscle_blood_flow_control_2008 @ v0.0.1

Guyton, Muscle, Blood, Flow, Control, 2008

nothing

Parameters:

Name Description
Z 1.0
MDFL1 10.0
POK 0.1
MDFLKM 0.667
AMM1LM 0.005
VV9 2.51
KORREN 0.0
ANGKNS 0.0
AURG 1.0
ANMALD 2.5
DTKA_init 0.0367573
AUTOGN 7.0
ALDMM 2.5
TRPL 0.0
TSSLML 0.15
POM 0.04
EARK 1.0
SR 1.0
ANMAM 1.4
RFCDFT 0.0
ANMLL 0.7
ANPXUL 10.0
O2VAD1_init 2.368e-7
VID1 0.01
RFABDP 1.0
TVD_init 0.000980838
ADHVUL 2.5
PCE 1.0
ANMTM 1.5
VTSF 6.0
RCDFPC 0.0
ANMNAM 1.0
AUY 0.0
RNAULL 0.3
HM8 4.714e-8
PM5 30.0
RNAUAD 0.0
PAEX 2.0
ANPC_init 1.0
CPPD 31.9719
OMM 57.1
EXCXP 1.0
HMD1_init 1.0
RFABX 0.8
VIC_init 25.0404
AMM2_init 1.09071
KORTC 10000.0
GPPD 1.0
AUS 1.0
AUX 1.0
PO2AMB 150.0
AMNAM 0.8
AHMNAR 0.3
ANMEM 1.6
VNTSTM 1.0
KORNER 0.0
ADHC_init 1.0
Z14 5.0
HMK 90.0
AULPM 0.0
VPTISS 0.0175
Z12 5.0
AMC_init 1.0
AMNAUL 15.0
Z5 0.3
ADHPUL 85.0
CPR 40.0
VPF1_init 0.0123238
TRNSFS 0.0
TSSLTC 0.005
AUM1 3.0
AUMAX 5.0
RVSM 1.0
RABSC 0.5
RFABKM 0.03
QAOLM 0.2
GLPCA 1.0
AR3T_init 1.1448
TIMETR 0.0
AUM2 1.0
GFNDMP 3.0
VRA1_init 0.100043
X 4.0
AU6_init 1.00132
AH11 1000.0
RAPRSP 0.0
RMULT1 1.0
RNAUGN 0.6
CFC 0.01167
CV 0.1
ANULL 0.8
AR1T_init 1.02127
KID 0.08
CMPTSS 2.0
PON 0.1
AR2T_init 1.01179
ADHKUL 5.0
EARLL 24.0
PA4 1.0
DTNARL 1.0e-6
AH10 0.333
QRF 0.15
AMM4 0.005
DIURET 1.0
KTOT_init 3622.54
HKM 0.53333
PMO 38.0666
SR2 1.0
SRK 5.0
MDFLW2 0.005
POM2 2.0
Z4 0.5
LPPR 0.03
RAM 96.3
CNR 139.0
Z6 20.0
ANUM 6.0
A3K 40000.0
PGHF -2.0
A4K 0.1
ANPXAF 1.5
ALCLK 0.3
ATRFBM 0.0
A4K2 40000.0
Z18 5.0
AUN1 0.5
ANY -0.2
URFORM 0.24
MDFLWX 0.01
QOM1_init 48.0839
VP_init 3.00449
AUV 0.55
REK 1.0
ANXM 0.0
VVS1_init 3.28246
OVA_init 204.497
VV6_init 0.0101913
AUTOSN 0.9
RNAUUL 10.0
HPL_init 1.00163
AARLL 4.0
ANPKNS 0.0
RVRS 19.167
ARF 0.5
STA 0.0
VP1 0.01
U 4.0
VRC_init 2.00439
A2K 60.0
TVDDL 30.0
VTW_init 39.8952
DTNAR 0.675
AHTHM 2.0
AMT 60.0
TRRBC 0.0
AMCSNS 0.65
KORGN 1.0
Z10 45.0
ANUVM 0.0
HM6 1850.0
AM1LL 0.0
OVS_init 0.699673
AHY_init 0.301963
ADHKLL 0.2
AUK 0.004
SRK2 10000.0
PXTP 8.0
VAS1_init 0.862514
PL2 1.8
CPK 0.000253
AM1UL 5.0
EXCML 0.01
AMNALL 0.04
BAROTC 0.16
AUL 1.5
RTSPRS 6.0
HPR_init 1.00237
Z7 5.0
HSR 1.0
AU4_init -0.060024
ANT 12.0
RKC 5.8e-6
FIS 0.0
EXC 1.0
PO2ADV 0.001
A1K 0.5
ANV 5000.0
PRP_init 216.243
RNAGTC 15.0
LPDE 8.0
AH9 1.0
ANCSNS 0.4
EXE 0.0
PK2 0.79167
ANC_init 0.859476
Z19 5.0
POR 35.0
VTS2_init 0.0
QO2T_init 72.2362
VLA1_init 0.379883
HTAUML 0.4
VIDML 0.01
ANMKEL 0.3
NID 0.1
AU1_init 1.00007
PR1LL 0.0
Z11 0.01
CRRFLX 0.0
TENSGN 0.0
TENSTC 0.05
ANMUL 1.8
RAR 30.52
CKEEX 4.0
ATRVM 0.0
ANX1_init 0.0
VPA1_init 0.38131
EFAFR 0.0
ANPTC 4.0
ADHPAM 0.3
DR 0.0
PAR1_init 103.525
HYL 60.0
GBL 0.0
PLUR_init 159.549
AR1LM 0.005
ADHVLL 0.93617
GFLC 0.0208333
AUMIN 0.4
NAE_init 2109.91
AR2LM 0.005
DHDTR 0.05
HSL 1.0
PCR 15.0
PPR1_init 0.419998
ANMARL 0.86
AARK 1.0
ADHTC 15.0
O2CHMO 0.01
LPK 2.728e-14
CPF 0.0003
EXCXP2 0.17
PC_init 16.9144
OSV_init 0.694163
TSP_init 279.945
Z13 0.625
GFNLL 0.001
RNAUG3_init 0.0
AUMK1 0.3
AMKM 0.5
MDMP 0.0
ADHINF 0.0
AUC1 0.3
CN7 0.2
RFABDM 0.3
ANPINF 0.0
CN2 0.0212
AMM1T_init 1.00269
RCDFDP 2000.0
GCOPF 0.8092
O2A 0.1
PLDF 4.2
ALDINF 0.0
VV7_init 0.00366525
RPS 0.0
Z16 5.0
ALDKNS 0.0
ANMSLT 2.0
RTPPR 0.9
AUDMP 0.3
ANMKEM 2.0
O2M 164.0
RTPPRS 15.2
POZ 2.0
RFN 1.22057
ANGINF 0.0
AMKMUL 12.0
AUSLP 1.5
AUTO 0.0

States:

Name Description
AMM2(time) 1.09071
AMM1T(time) 1.00269

Observables: none

guyton_muscle_oxygen_delivery_2008 @ v0.0.1

Guyton, Muscle, Oxygen, Delivery, 2008

nothing

Parameters:

Name Description
Z 1.0
MDFL1 10.0
POK 0.1
MDFLKM 0.667
AMM1LM 0.005
VV9 2.51
KORREN 0.0
ANGKNS 0.0
AURG 1.0
ANMALD 2.5
DTKA_init 0.0367573
AUTOGN 7.0
ALDMM 2.5
TRPL 0.0
TSSLML 0.15
POM 0.04
EARK 1.0
SR 1.0
ANMAM 1.4
RFCDFT 0.0
ANMLL 0.7
ANPXUL 10.0
O2VAD1_init 2.368e-7
VID1 0.01
HM 40.0381
RFABDP 1.0
TVD_init 0.000980838
ADHVUL 2.5
PCE 1.0
ANMTM 1.5
VTSF 6.0
RCDFPC 0.0
ANMNAM 1.0
AUY 0.0
RNAULL 0.3
HM8 4.714e-8
PM5 30.0
RNAUAD 0.0
PAEX 2.0
ANPC_init 1.0
CPPD 31.9719
OMM 57.1
EXCXP 1.0
HMD1_init 1.0
RFABX 0.8
VIC_init 25.0404
AMM2_init 1.09071
KORTC 10000.0
GPPD 1.0
AUS 1.0
AUX 1.0
PO2AMB 150.0
AMNAM 0.8
AHMNAR 0.3
ANMEM 1.6
VNTSTM 1.0
KORNER 0.0
ADHC_init 1.0
Z14 5.0
BFM 0.989949
HMK 90.0
AULPM 0.0
VPTISS 0.0175
Z12 5.0
AMC_init 1.0
AMNAUL 15.0
Z5 0.3
ADHPUL 85.0
CPR 40.0
VPF1_init 0.0123238
TRNSFS 0.0
TSSLTC 0.005
AUM1 3.0
AUMAX 5.0
RVSM 1.0
RABSC 0.5
RFABKM 0.03
QAOLM 0.2
GLPCA 1.0
AR3T_init 1.1448
TIMETR 0.0
AUM2 1.0
GFNDMP 3.0
VRA1_init 0.100043
X 4.0
AU6_init 1.00132
AH11 1000.0
RAPRSP 0.0
RMULT1 1.0
RNAUGN 0.6
CFC 0.01167
CV 0.1
ANULL 0.8
AR1T_init 1.02127
KID 0.08
CMPTSS 2.0
PON 0.1
AR2T_init 1.01179
ADHKUL 5.0
EARLL 24.0
PA4 1.0
DTNARL 1.0e-6
AH10 0.333
QRF 0.15
AMM4 0.005
DIURET 1.0
KTOT_init 3622.54
HKM 0.53333
SR2 1.0
SRK 5.0
MDFLW2 0.005
POM2 2.0
Z4 0.5
LPPR 0.03
RAM 96.3
CNR 139.0
Z6 20.0
ANUM 6.0
A3K 40000.0
PGHF -2.0
A4K 0.1
ANPXAF 1.5
ALCLK 0.3
ATRFBM 0.0
A4K2 40000.0
Z18 5.0
AUN1 0.5
OVA 204.497
ANY -0.2
URFORM 0.24
MDFLWX 0.01
QOM1_init 48.0839
VP_init 3.00449
AOM 1.00002
AUV 0.55
REK 1.0
ANXM 0.0
VVS1_init 3.28246
OVA_init 204.497
VV6_init 0.0101913
AUTOSN 0.9
RNAUUL 10.0
HPL_init 1.00163
AARLL 4.0
ANPKNS 0.0
RVRS 19.167
ARF 0.5
STA 0.0
VP1 0.01
U 4.0
VRC_init 2.00439
A2K 60.0
TVDDL 30.0
VTW_init 39.8952
DTNAR 0.675
AHTHM 2.0
AMT 60.0
TRRBC 0.0
AMCSNS 0.65
KORGN 1.0
Z10 45.0
ANUVM 0.0
HM6 1850.0
AM1LL 0.0
OVS_init 0.699673
AHY_init 0.301963
ADHKLL 0.2
AUK 0.004
SRK2 10000.0
PXTP 8.0
VAS1_init 0.862514
PL2 1.8
CPK 0.000253
AM1UL 5.0
EXCML 0.01
AMNALL 0.04
BAROTC 0.16
AUL 1.5
RTSPRS 6.0
HPR_init 1.00237
Z7 5.0
HSR 1.0
AU4_init -0.060024
ANT 12.0
RKC 5.8e-6
FIS 0.0
EXC 1.0
PO2ADV 0.001
A1K 0.5
ANV 5000.0
PRP_init 216.243
RNAGTC 15.0
LPDE 8.0
AH9 1.0
ANCSNS 0.4
EXE 0.0
PK2 0.79167
ANC_init 0.859476
Z19 5.0
POR 35.0
VTS2_init 0.0
QO2T_init 72.2362
VLA1_init 0.379883
HTAUML 0.4
VIDML 0.01
ANMKEL 0.3
NID 0.1
AU1_init 1.00007
PR1LL 0.0
Z11 0.01
CRRFLX 0.0
TENSGN 0.0
TENSTC 0.05
ANMUL 1.8
RAR 30.52
CKEEX 4.0
ATRVM 0.0
ANX1_init 0.0
VPA1_init 0.38131
EFAFR 0.0
ANPTC 4.0
ADHPAM 0.3
DR 0.0
PAR1_init 103.525
HYL 60.0
GBL 0.0
PLUR_init 159.549
AR1LM 0.005
ADHVLL 0.93617
GFLC 0.0208333
AUMIN 0.4
NAE_init 2109.91
AR2LM 0.005
DHDTR 0.05
HSL 1.0
PCR 15.0
PPR1_init 0.419998
ANMARL 0.86
AARK 1.0
ADHTC 15.0
O2CHMO 0.01
LPK 2.728e-14
CPF 0.0003
EXCXP2 0.17
PC_init 16.9144
OSV_init 0.694163
TSP_init 279.945
Z13 0.625
GFNLL 0.001
RNAUG3_init 0.0
AUMK1 0.3
AMKM 0.5
MDMP 0.0
ADHINF 0.0
AUC1 0.3
CN7 0.2
RFABDM 0.3
ANPINF 0.0
CN2 0.0212
AMM1T_init 1.00269
RCDFDP 2000.0
GCOPF 0.8092
O2A 0.1
PLDF 4.2
ALDINF 0.0
VV7_init 0.00366525
RPS 0.0
Z16 5.0
ALDKNS 0.0
ANMSLT 2.0
RTPPR 0.9
AUDMP 0.3
ANMKEM 2.0
O2M 164.0
RTPPRS 15.2
POZ 2.0
RFN 1.22057
ANGINF 0.0
AMKMUL 12.0
AUSLP 1.5
AUTO 0.0

States:

Name Description
QOM1(time) nothing
PVO(time) nothing

Observables: none

guyton_non_muscle_blood_flow_control_2008 @ v0.0.1

Guyton, Non, Muscle, Blood, Flow, Control, 2008

nothing

Parameters:

Name Description
Z 1.0
MDFL1 10.0
POK 0.1
MDFLKM 0.667
AMM1LM 0.005
VV9 2.51
KORREN 0.0
ANGKNS 0.0
AURG 1.0
ANMALD 2.5
DTKA_init 0.0367573
AUTOGN 7.0
ALDMM 2.5
TRPL 0.0
TSSLML 0.15
POM 0.04
EARK 1.0
SR 1.0
ANMAM 1.4
RFCDFT 0.0
ANMLL 0.7
ANPXUL 10.0
O2VAD1_init 2.368e-7
VID1 0.01
RFABDP 1.0
TVD_init 0.000980838
ADHVUL 2.5
PCE 1.0
ANMTM 1.5
VTSF 6.0
RCDFPC 0.0
ANMNAM 1.0
AUY 0.0
RNAULL 0.3
HM8 4.714e-8
PM5 30.0
RNAUAD 0.0
PAEX 2.0
ANPC_init 1.0
CPPD 31.9719
OMM 57.1
EXCXP 1.0
HMD1_init 1.0
RFABX 0.8
VIC_init 25.0404
AMM2_init 1.09071
KORTC 10000.0
GPPD 1.0
AUS 1.0
AUX 1.0
PO2AMB 150.0
AMNAM 0.8
AHMNAR 0.3
ANMEM 1.6
VNTSTM 1.0
KORNER 0.0
ADHC_init 1.0
Z14 5.0
HMK 90.0
AULPM 0.0
VPTISS 0.0175
Z12 5.0
AMC_init 1.0
AMNAUL 15.0
Z5 0.3
ADHPUL 85.0
CPR 40.0
VPF1_init 0.0123238
TRNSFS 0.0
TSSLTC 0.005
AUM1 3.0
AUMAX 5.0
RVSM 1.0
RABSC 0.5
RFABKM 0.03
QAOLM 0.2
GLPCA 1.0
AR3T_init 1.1448
TIMETR 0.0
AUM2 1.0
GFNDMP 3.0
VRA1_init 0.100043
X 4.0
AU6_init 1.00132
AH11 1000.0
RAPRSP 0.0
RMULT1 1.0
RNAUGN 0.6
CFC 0.01167
CV 0.1
ANULL 0.8
AR1T_init 1.02127
KID 0.08
CMPTSS 2.0
PON 0.1
AR2T_init 1.01179
ADHKUL 5.0
EARLL 24.0
PA4 1.0
DTNARL 1.0e-6
AH10 0.333
QRF 0.15
AMM4 0.005
DIURET 1.0
KTOT_init 3622.54
HKM 0.53333
SR2 1.0
SRK 5.0
MDFLW2 0.005
POM2 2.0
Z4 0.5
LPPR 0.03
RAM 96.3
CNR 139.0
Z6 20.0
ANUM 6.0
A3K 40000.0
PGHF -2.0
A4K 0.1
ANPXAF 1.5
ALCLK 0.3
ATRFBM 0.0
A4K2 40000.0
Z18 5.0
AUN1 0.5
ANY -0.2
URFORM 0.24
MDFLWX 0.01
QOM1_init 48.0839
VP_init 3.00449
AUV 0.55
REK 1.0
ANXM 0.0
VVS1_init 3.28246
OVA_init 204.497
VV6_init 0.0101913
AUTOSN 0.9
RNAUUL 10.0
HPL_init 1.00163
AARLL 4.0
ANPKNS 0.0
RVRS 19.167
ARF 0.5
STA 0.0
VP1 0.01
U 4.0
VRC_init 2.00439
A2K 60.0
TVDDL 30.0
VTW_init 39.8952
DTNAR 0.675
AHTHM 2.0
AMT 60.0
TRRBC 0.0
AMCSNS 0.65
KORGN 1.0
Z10 45.0
ANUVM 0.0
HM6 1850.0
AM1LL 0.0
OVS_init 0.699673
AHY_init 0.301963
ADHKLL 0.2
AUK 0.004
SRK2 10000.0
PXTP 8.0
VAS1_init 0.862514
PL2 1.8
CPK 0.000253
AM1UL 5.0
EXCML 0.01
AMNALL 0.04
BAROTC 0.16
AUL 1.5
RTSPRS 6.0
HPR_init 1.00237
Z7 5.0
HSR 1.0
AU4_init -0.060024
ANT 12.0
RKC 5.8e-6
FIS 0.0
EXC 1.0
PO2ADV 0.001
A1K 0.5
ANV 5000.0
PRP_init 216.243
RNAGTC 15.0
LPDE 8.0
AH9 1.0
ANCSNS 0.4
EXE 0.0
PK2 0.79167
ANC_init 0.859476
Z19 5.0
POR 35.0
VTS2_init 0.0
QO2T_init 72.2362
VLA1_init 0.379883
HTAUML 0.4
VIDML 0.01
ANMKEL 0.3
NID 0.1
AU1_init 1.00007
PR1LL 0.0
Z11 0.01
CRRFLX 0.0
TENSGN 0.0
TENSTC 0.05
ANMUL 1.8
RAR 30.52
CKEEX 4.0
ATRVM 0.0
ANX1_init 0.0
VPA1_init 0.38131
EFAFR 0.0
POT 35.1148
ADHPAM 0.3
DR 0.0
PAR1_init 103.525
HYL 60.0
GBL 0.0
PLUR_init 159.549
ANPTC 4.0
AR1LM 0.005
ADHVLL 0.93617
GFLC 0.0208333
AUMIN 0.4
NAE_init 2109.91
AR2LM 0.005
DHDTR 0.05
HSL 1.0
PCR 15.0
PPR1_init 0.419998
ANMARL 0.86
AARK 1.0
ADHTC 15.0
O2CHMO 0.01
LPK 2.728e-14
CPF 0.0003
EXCXP2 0.17
PC_init 16.9144
OSV_init 0.694163
TSP_init 279.945
Z13 0.625
GFNLL 0.001
RNAUG3_init 0.0
AUMK1 0.3
AMKM 0.5
MDMP 0.0
ADHINF 0.0
AUC1 0.3
CN7 0.2
RFABDM 0.3
ANPINF 0.0
CN2 0.0212
AMM1T_init 1.00269
RCDFDP 2000.0
GCOPF 0.8092
O2A 0.1
PLDF 4.2
ALDINF 0.0
VV7_init 0.00366525
RPS 0.0
Z16 5.0
ALDKNS 0.0
ANMSLT 2.0
RTPPR 0.9
AUDMP 0.3
ANMKEM 2.0
O2M 164.0
RTPPRS 15.2
POZ 2.0
RFN 1.22057
ANGINF 0.0
AMKMUL 12.0
AUSLP 1.5
AUTO 0.0

States:

Name Description
AR3T(time) 1.1448
AR2T(time) 1.01179
AR1T(time) 1.02127

Observables: none

guyton_non_muscle_oxygen_delivery_2008 @ v0.0.1

Guyton, Non, Muscle, Oxygen, Delivery, 2008

nothing

Parameters:

Name Description
Z 1.0
MDFL1 10.0
POK 0.1
MDFLKM 0.667
AMM1LM 0.005
VV9 2.51
KORREN 0.0
ANGKNS 0.0
AURG 1.0
ANMALD 2.5
DTKA_init 0.0367573
AUTOGN 7.0
ALDMM 2.5
TRPL 0.0
TSSLML 0.15
POM 0.04
EARK 1.0
SR 1.0
ANMAM 1.4
RFCDFT 0.0
ANMLL 0.7
BFN 2.79521
ANPXUL 10.0
O2VAD1_init 2.368e-7
VID1 0.01
HM 40.0381
RFABDP 1.0
TVD_init 0.000980838
ADHVUL 2.5
PCE 1.0
ANMTM 1.5
VTSF 6.0
RCDFPC 0.0
ANMNAM 1.0
AUY 0.0
RNAULL 0.3
HM8 4.714e-8
PM5 30.0
RNAUAD 0.0
PAEX 2.0
ANPC_init 1.0
CPPD 31.9719
OMM 57.1
EXCXP 1.0
HMD1_init 1.0
RFABX 0.8
VIC_init 25.0404
AMM2_init 1.09071
KORTC 10000.0
GPPD 1.0
AUS 1.0
AUX 1.0
PO2AMB 150.0
AMNAM 0.8
AHMNAR 0.3
ANMEM 1.6
VNTSTM 1.0
KORNER 0.0
ADHC_init 1.0
Z14 5.0
HMK 90.0
AULPM 0.0
VPTISS 0.0175
Z12 5.0
AMC_init 1.0
AMNAUL 15.0
Z5 0.3
ADHPUL 85.0
CPR 40.0
VPF1_init 0.0123238
TRNSFS 0.0
TSSLTC 0.005
AUM1 3.0
AUMAX 5.0
RVSM 1.0
RABSC 0.5
RFABKM 0.03
QAOLM 0.2
GLPCA 1.0
AR3T_init 1.1448
TIMETR 0.0
AUM2 1.0
GFNDMP 3.0
VRA1_init 0.100043
X 4.0
AU6_init 1.00132
AH11 1000.0
RAPRSP 0.0
RMULT1 1.0
RNAUGN 0.6
CFC 0.01167
CV 0.1
ANULL 0.8
AR1T_init 1.02127
KID 0.08
CMPTSS 2.0
PON 0.1
AR2T_init 1.01179
ADHKUL 5.0
EARLL 24.0
PA4 1.0
DTNARL 1.0e-6
AH10 0.333
QRF 0.15
AMM4 0.005
DIURET 1.0
KTOT_init 3622.54
HKM 0.53333
SR2 1.0
SRK 5.0
MDFLW2 0.005
POM2 2.0
Z4 0.5
LPPR 0.03
RAM 96.3
CNR 139.0
Z6 20.0
ANUM 6.0
A3K 40000.0
PGHF -2.0
A4K 0.1
ANPXAF 1.5
ALCLK 0.3
ATRFBM 0.0
A4K2 40000.0
Z18 5.0
AUN1 0.5
OVA 204.497
ANY -0.2
URFORM 0.24
MDFLWX 0.01
QOM1_init 48.0839
VP_init 3.00449
AOM 1.00002
AUV 0.55
REK 1.0
ANXM 0.0
VVS1_init 3.28246
OVA_init 204.497
VV6_init 0.0101913
AUTOSN 0.9
RNAUUL 10.0
HPL_init 1.00163
AARLL 4.0
ANPKNS 0.0
RVRS 19.167
ARF 0.5
STA 0.0
VP1 0.01
U 4.0
VRC_init 2.00439
A2K 60.0
TVDDL 30.0
VTW_init 39.8952
DTNAR 0.675
AHTHM 2.0
AMT 60.0
TRRBC 0.0
AMCSNS 0.65
KORGN 1.0
Z10 45.0
ANUVM 0.0
HM6 1850.0
AM1LL 0.0
OVS_init 0.699673
AHY_init 0.301963
ADHKLL 0.2
AUK 0.004
SRK2 10000.0
PXTP 8.0
VAS1_init 0.862514
PL2 1.8
CPK 0.000253
AM1UL 5.0
EXCML 0.01
AMNALL 0.04
BAROTC 0.16
AUL 1.5
RTSPRS 6.0
HPR_init 1.00237
Z7 5.0
HSR 1.0
AU4_init -0.060024
ANT 12.0
RKC 5.8e-6
FIS 0.0
EXC 1.0
PO2ADV 0.001
A1K 0.5
ANV 5000.0
PRP_init 216.243
RNAGTC 15.0
LPDE 8.0
AH9 1.0
ANCSNS 0.4
EXE 0.0
PK2 0.79167
ANC_init 0.859476
Z19 5.0
POR 35.0
VTS2_init 0.0
QO2T_init 72.2362
VLA1_init 0.379883
HTAUML 0.4
VIDML 0.01
ANMKEL 0.3
NID 0.1
AU1_init 1.00007
PR1LL 0.0
Z11 0.01
CRRFLX 0.0
TENSGN 0.0
TENSTC 0.05
ANMUL 1.8
RAR 30.52
CKEEX 4.0
ATRVM 0.0
ANX1_init 0.0
VPA1_init 0.38131
EFAFR 0.0
ANPTC 4.0
ADHPAM 0.3
DR 0.0
PAR1_init 103.525
HYL 60.0
GBL 0.0
PLUR_init 159.549
AR1LM 0.005
ADHVLL 0.93617
GFLC 0.0208333
AUMIN 0.4
NAE_init 2109.91
AR2LM 0.005
DHDTR 0.05
HSL 1.0
PCR 15.0
PPR1_init 0.419998
ANMARL 0.86
AARK 1.0
ADHTC 15.0
O2CHMO 0.01
LPK 2.728e-14
CPF 0.0003
EXCXP2 0.17
PC_init 16.9144
OSV_init 0.694163
TSP_init 279.945
Z13 0.625
GFNLL 0.001
RNAUG3_init 0.0
AUMK1 0.3
AMKM 0.5
MDMP 0.0
ADHINF 0.0
AUC1 0.3
CN7 0.2
RFABDM 0.3
ANPINF 0.0
CN2 0.0212
AMM1T_init 1.00269
RCDFDP 2000.0
GCOPF 0.8092
O2A 0.1
PLDF 4.2
ALDINF 0.0
VV7_init 0.00366525
RPS 0.0
Z16 5.0
ALDKNS 0.0
ANMSLT 2.0
RTPPR 0.9
AUDMP 0.3
ANMKEM 2.0
O2M 164.0
RTPPRS 15.2
POZ 2.0
RFN 1.22057
ANGINF 0.0
AMKMUL 12.0
AUSLP 1.5
AUTO 0.0

States:

Name Description
POV(time) nothing
QO2T(time) nothing

Observables: none

guyton_pulmonary_fluid_dynamics_2008 @ v0.0.1

Guyton, Pulmonary, Fluid, Dynamics, 2008

nothing

Parameters:

Name Description
Z 1.0
MDFL1 10.0
POK 0.1
MDFLKM 0.667
AMM1LM 0.005
VV9 2.51
KORREN 0.0
ANGKNS 0.0
AURG 1.0
ANMALD 2.5
DTKA_init 0.0367573
AUTOGN 7.0
ALDMM 2.5
TRPL 0.0
TSSLML 0.15
POM 0.04
EARK 1.0
SR 1.0
ANMAM 1.4
RFCDFT 0.0
ANMLL 0.7
ANPXUL 10.0
O2VAD1_init 2.368e-7
VID1 0.01
PLA 2.0
RFABDP 1.0
TVD_init 0.000980838
ADHVUL 2.5
PCE 1.0
ANMTM 1.5
VTSF 6.0
RCDFPC 0.0
ANMNAM 1.0
AUY 0.0
RNAULL 0.3
HM8 4.714e-8
PM5 30.0
RNAUAD 0.0
PAEX 2.0
ANPC_init 1.0
CPPD 31.9719
OMM 57.1
EXCXP 1.0
HMD1_init 1.0
RFABX 0.8
VIC_init 25.0404
AMM2_init 1.09071
KORTC 10000.0
GPPD 1.0
AUS 1.0
AUX 1.0
PO2AMB 150.0
AMNAM 0.8
AHMNAR 0.3
ANMEM 1.6
VNTSTM 1.0
KORNER 0.0
ADHC_init 1.0
Z14 5.0
HMK 90.0
AULPM 0.0
VPTISS 0.0175
Z12 5.0
AMC_init 1.0
AMNAUL 15.0
Z5 0.3
ADHPUL 85.0
CPR 40.0
VPF1_init 0.0123238
TRNSFS 0.0
TSSLTC 0.005
AUM1 3.0
AUMAX 5.0
RVSM 1.0
RABSC 0.5
RFABKM 0.03
QAOLM 0.2
GLPCA 1.0
AR3T_init 1.1448
TIMETR 0.0
AUM2 1.0
GFNDMP 3.0
VRA1_init 0.100043
X 4.0
AU6_init 1.00132
AH11 1000.0
RAPRSP 0.0
RMULT1 1.0
RNAUGN 0.6
CFC 0.01167
CV 0.1
ANULL 0.8
AR1T_init 1.02127
KID 0.08
CMPTSS 2.0
PON 0.1
AR2T_init 1.01179
ADHKUL 5.0
PPC 29.9941
EARLL 24.0
PA4 1.0
DTNARL 1.0e-6
AH10 0.333
QRF 0.15
AMM4 0.005
DIURET 1.0
KTOT_init 3622.54
HKM 0.53333
SR2 1.0
SRK 5.0
MDFLW2 0.005
POM2 2.0
Z4 0.5
LPPR 0.03
RAM 96.3
CNR 139.0
Z6 20.0
ANUM 6.0
A3K 40000.0
PGHF -2.0
PPA 15.6376
A4K 0.1
ANPXAF 1.5
ALCLK 0.3
ATRFBM 0.0
A4K2 40000.0
Z18 5.0
AUN1 0.5
ANY -0.2
URFORM 0.24
MDFLWX 0.01
QOM1_init 48.0839
VP_init 3.00449
AUV 0.55
RPV 1.55719
REK 1.0
ANXM 0.0
VVS1_init 3.28246
OVA_init 204.497
VV6_init 0.0101913
AUTOSN 0.9
RNAUUL 10.0
HPL_init 1.00163
AARLL 4.0
ANPKNS 0.0
RVRS 19.167
ARF 0.5
STA 0.0
VP1 0.01
U 4.0
VRC_init 2.00439
A2K 60.0
TVDDL 30.0
VTW_init 39.8952
DTNAR 0.675
AHTHM 2.0
AMCSNS 0.65
TRRBC 0.0
AMT 60.0
KORGN 1.0
Z10 45.0
ANUVM 0.0
HM6 1850.0
AM1LL 0.0
OVS_init 0.699673
AHY_init 0.301963
CPP 71.9719
ADHKLL 0.2
AUK 0.004
SRK2 10000.0
PXTP 8.0
VAS1_init 0.862514
PL2 1.8
CPK 0.000253
AM1UL 5.0
EXCML 0.01
AMNALL 0.04
BAROTC 0.16
AUL 1.5
RTSPRS 6.0
HPR_init 1.00237
Z7 5.0
HSR 1.0
AU4_init -0.060024
ANT 12.0
RKC 5.8e-6
FIS 0.0
EXC 1.0
PO2ADV 0.001
A1K 0.5
ANV 5000.0
PRP_init 216.243
RNAGTC 15.0
LPDE 8.0
AH9 1.0
ANCSNS 0.4
EXE 0.0
PK2 0.79167
ANC_init 0.859476
Z19 5.0
POR 35.0
VTS2_init 0.0
QO2T_init 72.2362
VLA1_init 0.379883
HTAUML 0.4
VIDML 0.01
ANMKEL 0.3
NID 0.1
AU1_init 1.00007
PR1LL 0.0
Z11 0.01
CRRFLX 0.0
TENSGN 0.0
TENSTC 0.05
ANMUL 1.8
RAR 30.52
CKEEX 4.0
ATRVM 0.0
ANX1_init 0.0
VPA1_init 0.38131
EFAFR 0.0
ANPTC 4.0
ADHPAM 0.3
DR 0.0
PAR1_init 103.525
HYL 60.0
GBL 0.0
PLUR_init 159.549
AR1LM 0.005
ADHVLL 0.93617
GFLC 0.0208333
AUMIN 0.4
NAE_init 2109.91
AR2LM 0.005
DHDTR 0.05
HSL 1.0
PCR 15.0
PPR1_init 0.419998
ANMARL 0.86
AARK 1.0
ADHTC 15.0
O2CHMO 0.01
LPK 2.728e-14
CPF 0.0003
EXCXP2 0.17
PC_init 16.9144
OSV_init 0.694163
TSP_init 279.945
Z13 0.625
GFNLL 0.001
RNAUG3_init 0.0
AUMK1 0.3
AMKM 0.5
MDMP 0.0
ADHINF 0.0
AUC1 0.3
CN7 0.2
RFABDM 0.3
ANPINF 0.0
CN2 0.0212
AMM1T_init 1.00269
RCDFDP 2000.0
RPA 1.5683
GCOPF 0.8092
O2A 0.1
PLDF 4.2
ALDINF 0.0
VV7_init 0.00366525
RPS 0.0
Z16 5.0
ALDKNS 0.0
ANMSLT 2.0
RTPPR 0.9
AUDMP 0.3
ANMKEM 2.0
O2M 164.0
RTPPRS 15.2
POZ 2.0
RFN 1.22057
ANGINF 0.0
AMKMUL 12.0
AUSLP 1.5
AUTO 0.0

States:

Name Description
PPR1(time) 0.419998
VPF1(time) 0.0123238

Observables: none

guyton_pulmonary_oxygen_uptake_2008 @ v0.0.1

Guyton, Pulmonary, Oxygen, Uptake, 2008

nothing

Parameters:

Name Description
Z 1.0
MDFL1 10.0
POK 0.1
MDFLKM 0.667
AMM1LM 0.005
VV9 2.51
QRO 4.97838
KORREN 0.0
ANGKNS 0.0
AURG 1.0
ANMALD 2.5
DTKA_init 0.0367573
AUTOGN 7.0
ALDMM 2.5
TRPL 0.0
TSSLML 0.15
POM 0.04
EARK 1.0
SR 1.0
RMO 56.8057
ANMAM 1.4
RFCDFT 0.0
ANMLL 0.7
ANPXUL 10.0
O2VAD1_init 2.368e-7
HM 40.0381
VID1 0.01
RFABDP 1.0
TVD_init 0.000980838
ADHVUL 2.5
PCE 1.0
ANMTM 1.5
VTSF 6.0
RCDFPC 0.0
ANMNAM 1.0
AUY 0.0
RNAULL 0.3
HM8 4.714e-8
PM5 30.0
RNAUAD 0.0
PAEX 2.0
ANPC_init 1.0
CPPD 31.9719
OMM 57.1
EXCXP 1.0
HMD1_init 1.0
RFABX 0.8
VIC_init 25.0404
AMM2_init 1.09071
KORTC 10000.0
GPPD 1.0
AUS 1.0
AUX 1.0
PO2AMB 150.0
AMNAM 0.8
AHMNAR 0.3
ANMEM 1.6
VNTSTM 1.0
KORNER 0.0
ADHC_init 1.0
Z14 5.0
HMK 90.0
AULPM 0.0
VPTISS 0.0175
Z12 5.0
AMC_init 1.0
AMNAUL 15.0
Z5 0.3
ADHPUL 85.0
CPR 40.0
VPF1_init 0.0123238
TRNSFS 0.0
TSSLTC 0.005
AUM1 3.0
AUMAX 5.0
RVSM 1.0
RABSC 0.5
RFABKM 0.03
QAOLM 0.2
GLPCA 1.0
AR3T_init 1.1448
TIMETR 0.0
AUM2 1.0
GFNDMP 3.0
VRA1_init 0.100043
X 4.0
AU6_init 1.00132
AH11 1000.0
RAPRSP 0.0
RMULT1 1.0
RNAUGN 0.6
CFC 0.01167
CV 0.1
ANULL 0.8
AR1T_init 1.02127
KID 0.08
CMPTSS 2.0
PON 0.1
AR2T_init 1.01179
ADHKUL 5.0
EARLL 24.0
PA4 1.0
DTNARL 1.0e-6
AH10 0.333
QRF 0.15
AMM4 0.005
DIURET 1.0
KTOT_init 3622.54
HKM 0.53333
SR2 1.0
SRK 5.0
MDFLW2 0.005
POM2 2.0
Z4 0.5
LPPR 0.03
RAM 96.3
CNR 139.0
Z6 20.0
ANUM 6.0
A3K 40000.0
PGHF -2.0
A4K 0.1
ANPXAF 1.5
ALCLK 0.3
ATRFBM 0.0
A4K2 40000.0
Z18 5.0
AUN1 0.5
ANY -0.2
URFORM 0.24
MDFLWX 0.01
QOM1_init 48.0839
VP_init 3.00449
AUV 0.55
REK 1.0
ANXM 0.0
VVS1_init 3.28246
OVA_init 204.497
VV6_init 0.0101913
AUTOSN 0.9
RNAUUL 10.0
HPL_init 1.00163
AARLL 4.0
ANPKNS 0.0
RVRS 19.167
ARF 0.5
STA 0.0
VP1 0.01
U 4.0
VRC_init 2.00439
A2K 60.0
TVDDL 30.0
VTW_init 39.8952
DTNAR 0.675
AHTHM 2.0
AMCSNS 0.65
TRRBC 0.0
AMT 60.0
KORGN 1.0
Z10 45.0
ANUVM 0.0
HM6 1850.0
AM1LL 0.0
OVS_init 0.699673
AHY_init 0.301963
ADHKLL 0.2
AUK 0.004
SRK2 10000.0
PXTP 8.0
VAS1_init 0.862514
DOB 163.508
PL2 1.8
CPK 0.000253
AM1UL 5.0
EXCML 0.01
AMNALL 0.04
BAROTC 0.16
AUL 1.5
RTSPRS 6.0
HPR_init 1.00237
Z7 5.0
HSR 1.0
AU4_init -0.060024
ANT 12.0
RKC 5.8e-6
FIS 0.0
EXC 1.0
PO2ADV 0.001
A1K 0.5
VPF 0.0123238
ANV 5000.0
PRP_init 216.243
RNAGTC 15.0
LPDE 8.0
AH9 1.0
ANCSNS 0.4
EXE 0.0
PK2 0.79167
ANC_init 0.859476
Z19 5.0
POR 35.0
VTS2_init 0.0
QO2T_init 72.2362
VLA1_init 0.379883
HTAUML 0.4
VIDML 0.01
ANMKEL 0.3
NID 0.1
AU1_init 1.00007
PR1LL 0.0
Z11 0.01
CRRFLX 0.0
TENSGN 0.0
TENSTC 0.05
ANMUL 1.8
RAR 30.52
CKEEX 4.0
ATRVM 0.0
ANX1_init 0.0
VPA1_init 0.38131
EFAFR 0.0
ANPTC 4.0
ADHPAM 0.3
DR 0.0
PAR1_init 103.525
HYL 60.0
GBL 0.0
PLUR_init 159.549
AR1LM 0.005
ADHVLL 0.93617
GFLC 0.0208333
AUMIN 0.4
NAE_init 2109.91
AR2LM 0.005
DHDTR 0.05
HSL 1.0
PCR 15.0
PPR1_init 0.419998
ANMARL 0.86
AARK 1.0
ADHTC 15.0
O2CHMO 0.01
LPK 2.728e-14
CPF 0.0003
EXCXP2 0.17
PC_init 16.9144
OSV_init 0.694163
TSP_init 279.945
Z13 0.625
GFNLL 0.001
RNAUG3_init 0.0
AUMK1 0.3
AMKM 0.5
MDMP 0.0
ADHINF 0.0
AUC1 0.3
CN7 0.2
RFABDM 0.3
ANPINF 0.0
CN2 0.0212
AMM1T_init 1.00269
RCDFDP 2000.0
GCOPF 0.8092
O2A 0.1
PLDF 4.2
ALDINF 0.0
VV7_init 0.00366525
RPS 0.0
Z16 5.0
ALDKNS 0.0
ANMSLT 2.0
RTPPR 0.9
AUDMP 0.3
ANMKEM 2.0
O2M 164.0
RTPPRS 15.2
POZ 2.0
RFN 1.22057
ANGINF 0.0
AMKMUL 12.0
AUSLP 1.5
AUTO 0.0

States:

Name Description
OVA(time) 204.497
O2VAD1(time) 2.368e-7

Observables: none

guyton_red_cells_and_viscosity_2008 @ v0.0.1

Guyton, Red, Cells, And, Viscosity, 2008

nothing

Parameters:

Name Description
Z 1.0
MDFL1 10.0
POK 0.1
MDFLKM 0.667
AMM1LM 0.005
VV9 2.51
KORREN 0.0
ANGKNS 0.0
AURG 1.0
ANMALD 2.5
DTKA_init 0.0367573
AUTOGN 7.0
ALDMM 2.5
TRPL 0.0
TSSLML 0.15
POM 0.04
EARK 1.0
SR 1.0
ANMAM 1.4
RFCDFT 0.0
ANMLL 0.7
ANPXUL 10.0
O2VAD1_init 2.368e-7
VID1 0.01
RFABDP 1.0
TVD_init 0.000980838
ADHVUL 2.5
PCE 1.0
ANMTM 1.5
VTSF 6.0
RCDFPC 0.0
ANMNAM 1.0
AUY 0.0
RNAULL 0.3
HM8 4.714e-8
PM5 30.0
RNAUAD 0.0
PAEX 2.0
ANPC_init 1.0
CPPD 31.9719
OMM 57.1
EXCXP 1.0
HMD1_init 1.0
RFABX 0.8
VIC_init 25.0404
AMM2_init 1.09071
KORTC 10000.0
GPPD 1.0
AUS 1.0
AUX 1.0
PO2AMB 150.0
AMNAM 0.8
AHMNAR 0.3
ANMEM 1.6
VNTSTM 1.0
KORNER 0.0
ADHC_init 1.0
Z14 5.0
HMK 90.0
AULPM 0.0
VPTISS 0.0175
Z12 5.0
AMC_init 1.0
AMNAUL 15.0
Z5 0.3
ADHPUL 85.0
CPR 40.0
VPF1_init 0.0123238
TRNSFS 0.0
TSSLTC 0.005
AUM1 3.0
AUMAX 5.0
RVSM 1.0
RABSC 0.5
RFABKM 0.03
VP 3.00449
QAOLM 0.2
GLPCA 1.0
AR3T_init 1.1448
TIMETR 0.0
AUM2 1.0
GFNDMP 3.0
VRA1_init 0.100043
X 4.0
AU6_init 1.00132
AH11 1000.0
RAPRSP 0.0
RMULT1 1.0
RNAUGN 0.6
CFC 0.01167
CV 0.1
ANULL 0.8
AR1T_init 1.02127
KID 0.08
CMPTSS 2.0
PON 0.1
AR2T_init 1.01179
ADHKUL 5.0
EARLL 24.0
PA4 1.0
DTNARL 1.0e-6
AH10 0.333
QRF 0.15
HKM 0.53333
AMM4 0.005
KTOT_init 3622.54
DIURET 1.0
SR2 1.0
SRK 5.0
MDFLW2 0.005
POM2 2.0
Z4 0.5
LPPR 0.03
RAM 96.3
CNR 139.0
Z6 20.0
ANUM 6.0
A3K 40000.0
PGHF -2.0
A4K 0.1
ANPXAF 1.5
ALCLK 0.3
ATRFBM 0.0
A4K2 40000.0
Z18 5.0
AUN1 0.5
ANY -0.2
URFORM 0.24
MDFLWX 0.01
QOM1_init 48.0839
VP_init 3.00449
AUV 0.55
REK 1.0
ANXM 0.0
VVS1_init 3.28246
OVA_init 204.497
VV6_init 0.0101913
AUTOSN 0.9
RNAUUL 10.0
HPL_init 1.00163
AARLL 4.0
ANPKNS 0.0
RVRS 19.167
ARF 0.5
STA 0.0
VP1 0.01
U 4.0
VRC_init 2.00439
A2K 60.0
TVDDL 30.0
VTW_init 39.8952
DTNAR 0.675
AHTHM 2.0
AMCSNS 0.65
TRRBC 0.0
AMT 60.0
KORGN 1.0
Z10 45.0
HM6 1850.0
ANUVM 0.0
AM1LL 0.0
OVS_init 0.699673
AHY_init 0.301963
ADHKLL 0.2
AUK 0.004
SRK2 10000.0
PXTP 8.0
VAS1_init 0.862514
PL2 1.8
CPK 0.000253
AM1UL 5.0
EXCML 0.01
AMNALL 0.04
BAROTC 0.16
AUL 1.5
RTSPRS 6.0
HPR_init 1.00237
Z7 5.0
HSR 1.0
AU4_init -0.060024
ANT 12.0
RKC 5.8e-6
FIS 0.0
EXC 1.0
PO2ADV 0.001
A1K 0.5
ANV 5000.0
PRP_init 216.243
RNAGTC 15.0
LPDE 8.0
AH9 1.0
ANCSNS 0.4
EXE 0.0
PK2 0.79167
ANC_init 0.859476
Z19 5.0
POR 35.0
VTS2_init 0.0
QO2T_init 72.2362
VLA1_init 0.379883
HTAUML 0.4
VIDML 0.01
ANMKEL 0.3
NID 0.1
AU1_init 1.00007
PR1LL 0.0
Z11 0.01
CRRFLX 0.0
TENSGN 0.0
TENSTC 0.05
ANMUL 1.8
RAR 30.52
CKEEX 4.0
ATRVM 0.0
ANX1_init 0.0
VPA1_init 0.38131
EFAFR 0.0
ANPTC 4.0
ADHPAM 0.3
DR 0.0
PAR1_init 103.525
HYL 60.0
GBL 0.0
PLUR_init 159.549
AR1LM 0.005
ADHVLL 0.93617
GFLC 0.0208333
AUMIN 0.4
NAE_init 2109.91
AR2LM 0.005
DHDTR 0.05
HSL 1.0
PCR 15.0
PPR1_init 0.419998
ANMARL 0.86
AARK 1.0
ADHTC 15.0
O2CHMO 0.01
LPK 2.728e-14
CPF 0.0003
EXCXP2 0.17
PC_init 16.9144
OSV_init 0.694163
TSP_init 279.945
Z13 0.625
GFNLL 0.001
RNAUG3_init 0.0
AUMK1 0.3
AMKM 0.5
MDMP 0.0
ADHINF 0.0
AUC1 0.3
CN7 0.2
RFABDM 0.3
ANPINF 0.0
CN2 0.0212
AMM1T_init 1.00269
RCDFDP 2000.0
GCOPF 0.8092
O2A 0.1
PLDF 4.2
ALDINF 0.0
VV7_init 0.00366525
RPS 0.0
Z16 5.0
ALDKNS 0.0
ANMSLT 2.0
RTPPR 0.9
AUDMP 0.3
ANMKEM 2.0
O2M 164.0
RTPPRS 15.2
POZ 2.0
RFN 1.22057
ANGINF 0.0
AMKMUL 12.0
AUSLP 1.5
AUTO 0.0

States:

Name Description
VRC(time) 2.00439

Observables: none

guyton_stress_relaxation_2008 @ v0.0.1

Guyton, Stress, Relaxation, 2008

nothing

Parameters:

Name Description
Z 1.0
MDFL1 10.0
POK 0.1
MDFLKM 0.667
AMM1LM 0.005
VV9 2.51
KORREN 0.0
ANGKNS 0.0
AURG 1.0
ANMALD 2.5
DTKA_init 0.0367573
AUTOGN 7.0
ALDMM 2.5
TRPL 0.0
TSSLML 0.15
POM 0.04
EARK 1.0
SR 1.0
ANMAM 1.4
RFCDFT 0.0
ANMLL 0.7
ANPXUL 10.0
O2VAD1_init 2.368e-7
VID1 0.01
RFABDP 1.0
TVD_init 0.000980838
ADHVUL 2.5
PCE 1.0
ANMTM 1.5
VTSF 6.0
RCDFPC 0.0
ANMNAM 1.0
AUY 0.0
RNAULL 0.3
HM8 4.714e-8
PM5 30.0
RNAUAD 0.0
PAEX 2.0
ANPC_init 1.0
CPPD 31.9719
OMM 57.1
EXCXP 1.0
HMD1_init 1.0
RFABX 0.8
VIC_init 25.0404
AMM2_init 1.09071
KORTC 10000.0
GPPD 1.0
AUS 1.0
AUX 1.0
PO2AMB 150.0
AMNAM 0.8
AHMNAR 0.3
ANMEM 1.6
VNTSTM 1.0
KORNER 0.0
ADHC_init 1.0
Z14 5.0
HMK 90.0
AULPM 0.0
VPTISS 0.0175
Z12 5.0
AMC_init 1.0
AMNAUL 15.0
Z5 0.3
ADHPUL 85.0
CPR 40.0
VPF1_init 0.0123238
TRNSFS 0.0
TSSLTC 0.005
AUM1 3.0
AUMAX 5.0
RVSM 1.0
RABSC 0.5
RFABKM 0.03
QAOLM 0.2
GLPCA 1.0
AR3T_init 1.1448
TIMETR 0.0
AUM2 1.0
GFNDMP 3.0
VRA1_init 0.100043
X 4.0
AU6_init 1.00132
AH11 1000.0
RAPRSP 0.0
RMULT1 1.0
RNAUGN 0.6
CFC 0.01167
CV 0.1
ANULL 0.8
AR1T_init 1.02127
KID 0.08
CMPTSS 2.0
PON 0.1
AR2T_init 1.01179
ADHKUL 5.0
VVE 0.743224
EARLL 24.0
PA4 1.0
DTNARL 1.0e-6
AH10 0.333
QRF 0.15
AMM4 0.005
DIURET 1.0
KTOT_init 3622.54
HKM 0.53333
SR2 1.0
SRK 5.0
MDFLW2 0.005
POM2 2.0
Z4 0.5
LPPR 0.03
RAM 96.3
CNR 139.0
Z6 20.0
ANUM 6.0
A3K 40000.0
PGHF -2.0
A4K 0.1
ANPXAF 1.5
ALCLK 0.3
ATRFBM 0.0
A4K2 40000.0
Z18 5.0
AUN1 0.5
ANY -0.2
URFORM 0.24
MDFLWX 0.01
QOM1_init 48.0839
VP_init 3.00449
AUV 0.55
REK 1.0
ANXM 0.0
VVS1_init 3.28246
OVA_init 204.497
VV6_init 0.0101913
AUTOSN 0.9
RNAUUL 10.0
HPL_init 1.00163
AARLL 4.0
ANPKNS 0.0
RVRS 19.167
ARF 0.5
STA 0.0
VP1 0.01
U 4.0
VRC_init 2.00439
A2K 60.0
TVDDL 30.0
VTW_init 39.8952
DTNAR 0.675
AHTHM 2.0
AMT 60.0
TRRBC 0.0
AMCSNS 0.65
KORGN 1.0
Z10 45.0
ANUVM 0.0
HM6 1850.0
AM1LL 0.0
OVS_init 0.699673
AHY_init 0.301963
ADHKLL 0.2
AUK 0.004
SRK2 10000.0
PXTP 8.0
VAS1_init 0.862514
PL2 1.8
CPK 0.000253
AM1UL 5.0
EXCML 0.01
AMNALL 0.04
BAROTC 0.16
AUL 1.5
RTSPRS 6.0
HPR_init 1.00237
Z7 5.0
HSR 1.0
AU4_init -0.060024
ANT 12.0
RKC 5.8e-6
FIS 0.0
EXC 1.0
PO2ADV 0.001
A1K 0.5
ANV 5000.0
PRP_init 216.243
RNAGTC 15.0
LPDE 8.0
AH9 1.0
ANCSNS 0.4
EXE 0.0
PK2 0.79167
ANC_init 0.859476
Z19 5.0
POR 35.0
VTS2_init 0.0
QO2T_init 72.2362
VLA1_init 0.379883
HTAUML 0.4
VIDML 0.01
ANMKEL 0.3
NID 0.1
AU1_init 1.00007
PR1LL 0.0
Z11 0.01
CRRFLX 0.0
TENSGN 0.0
TENSTC 0.05
ANMUL 1.8
RAR 30.52
CKEEX 4.0
ATRVM 0.0
ANX1_init 0.0
VPA1_init 0.38131
EFAFR 0.0
ANPTC 4.0
ADHPAM 0.3
DR 0.0
PAR1_init 103.525
HYL 60.0
GBL 0.0
PLUR_init 159.549
AR1LM 0.005
ADHVLL 0.93617
GFLC 0.0208333
AUMIN 0.4
NAE_init 2109.91
AR2LM 0.005
DHDTR 0.05
HSL 1.0
PCR 15.0
PPR1_init 0.419998
ANMARL 0.86
AARK 1.0
ADHTC 15.0
O2CHMO 0.01
LPK 2.728e-14
CPF 0.0003
EXCXP2 0.17
PC_init 16.9144
OSV_init 0.694163
TSP_init 279.945
Z13 0.625
GFNLL 0.001
RNAUG3_init 0.0
AUMK1 0.3
AMKM 0.5
MDMP 0.0
ADHINF 0.0
AUC1 0.3
CN7 0.2
RFABDM 0.3
ANPINF 0.0
CN2 0.0212
AMM1T_init 1.00269
RCDFDP 2000.0
GCOPF 0.8092
O2A 0.1
PLDF 4.2
ALDINF 0.0
VV7_init 0.00366525
RPS 0.0
Z16 5.0
ALDKNS 0.0
ANMSLT 2.0
RTPPR 0.9
AUDMP 0.3
ANMKEM 2.0
O2M 164.0
RTPPRS 15.2
POZ 2.0
RFN 1.22057
ANGINF 0.0
AMKMUL 12.0
AUSLP 1.5
AUTO 0.0

States:

Name Description
VV7(time) 0.00366525
VV6(time) 0.0101913

Observables: none

guyton_thirst_drinking_and_salt_appetite_2008 @ v0.0.1

Guyton, Thirst, Drinking, And, Salt, Appetite, 2008

nothing

Parameters:

Name Description
Z 1.0
MDFL1 10.0
POK 0.1
MDFLKM 0.667
AMM1LM 0.005
VV9 2.51
KORREN 0.0
ANGKNS 0.0
AURG 1.0
ANMALD 2.5
DTKA_init 0.0367573
AUTOGN 7.0
ALDMM 2.5
TRPL 0.0
TSSLML 0.15
POM 0.04
EARK 1.0
SR 1.0
ANMAM 1.4
RFCDFT 0.0
ANMLL 0.7
ANPXUL 10.0
O2VAD1_init 2.368e-7
VID1 0.01
RFABDP 1.0
TVD_init 0.000980838
ADHVUL 2.5
PCE 1.0
ANMTM 1.5
VTSF 6.0
RCDFPC 0.0
ANMNAM 1.0
AUY 0.0
RNAULL 0.3
HM8 4.714e-8
PM5 30.0
RNAUAD 0.0
PAEX 2.0
ANPC_init 1.0
CPPD 31.9719
OMM 57.1
EXCXP 1.0
HMD1_init 1.0
RFABX 0.8
VIC_init 25.0404
AMM2_init 1.09071
KORTC 10000.0
GPPD 1.0
AUS 1.0
AUX 1.0
PO2AMB 150.0
AMNAM 0.8
AHMNAR 0.3
ANMEM 1.6
VNTSTM 1.0
KORNER 0.0
ADHC_init 1.0
Z14 5.0
HMK 90.0
AULPM 0.0
VPTISS 0.0175
Z12 5.0
AMC_init 1.0
AMNAUL 15.0
Z5 0.3
ADHPUL 85.0
CPR 40.0
VPF1_init 0.0123238
TRNSFS 0.0
TSSLTC 0.005
AUM1 3.0
AUMAX 5.0
RVSM 1.0
RABSC 0.5
RFABKM 0.03
QAOLM 0.2
GLPCA 1.0
AR3T_init 1.1448
TIMETR 0.0
AUM2 1.0
GFNDMP 3.0
VRA1_init 0.100043
X 4.0
AU6_init 1.00132
AH11 1000.0
RAPRSP 0.0
RMULT1 1.0
RNAUGN 0.6
CFC 0.01167
CV 0.1
ANULL 0.8
AR1T_init 1.02127
KID 0.08
CMPTSS 2.0
PON 0.1
AR2T_init 1.01179
ADHKUL 5.0
EARLL 24.0
PA4 1.0
DTNARL 1.0e-6
AH10 0.333
QRF 0.15
AMM4 0.005
DIURET 1.0
KTOT_init 3622.54
HKM 0.53333
SR2 1.0
SRK 5.0
MDFLW2 0.005
POM2 2.0
Z4 0.5
LPPR 0.03
RAM 96.3
CNR 139.0
Z6 20.0
ANUM 6.0
A3K 40000.0
PGHF -2.0
A4K 0.1
ANPXAF 1.5
ALCLK 0.3
ATRFBM 0.0
A4K2 40000.0
Z18 5.0
AUN1 0.5
ANY -0.2
URFORM 0.24
MDFLWX 0.01
QOM1_init 48.0839
VP_init 3.00449
AUV 0.55
REK 1.0
ANXM 0.0
VVS1_init 3.28246
OVA_init 204.497
VV6_init 0.0101913
AUTOSN 0.9
RNAUUL 10.0
HPL_init 1.00163
AARLL 4.0
ANPKNS 0.0
RVRS 19.167
ARF 0.5
STA 0.0
VP1 0.01
U 4.0
VRC_init 2.00439
A2K 60.0
TVDDL 30.0
VTW_init 39.8952
DTNAR 0.675
AHTHM 2.0
AMCSNS 0.65
TRRBC 0.0
AMT 60.0
KORGN 1.0
Z10 45.0
ANUVM 0.0
HM6 1850.0
AM1LL 0.0
OVS_init 0.699673
AHY_init 0.301963
ADHKLL 0.2
AUK 0.004
SRK2 10000.0
ANM 0.987545
PXTP 8.0
VAS1_init 0.862514
PL2 1.8
CPK 0.000253
AM1UL 5.0
EXCML 0.01
AMNALL 0.04
BAROTC 0.16
AUL 1.5
RTSPRS 6.0
HPR_init 1.00237
Z7 5.0
HSR 1.0
AU4_init -0.060024
ANT 12.0
RKC 5.8e-6
FIS 0.0
EXC 1.0
PO2ADV 0.001
A1K 0.5
ANV 5000.0
PRP_init 216.243
RNAGTC 15.0
LPDE 8.0
AH9 1.0
ANCSNS 0.4
EXE 0.0
PK2 0.79167
ANC_init 0.859476
Z19 5.0
POR 35.0
VTS2_init 0.0
QO2T_init 72.2362
VLA1_init 0.379883
HTAUML 0.4
VIDML 0.01
ANMKEL 0.3
NID 0.1
AU1_init 1.00007
Z11 0.01
PR1LL 0.0
CRRFLX 0.0
TENSGN 0.0
TENSTC 0.05
ANMUL 1.8
RAR 30.52
CKEEX 4.0
ATRVM 0.0
ANX1_init 0.0
VPA1_init 0.38131
EFAFR 0.0
POT 35.1148
ADHPAM 0.3
DR 0.0
PAR1_init 103.525
HYL 60.0
GBL 0.0
PLUR_init 159.549
ANPTC 4.0
AR1LM 0.005
ADHVLL 0.93617
GFLC 0.0208333
AUMIN 0.4
NAE_init 2109.91
AR2LM 0.005
DHDTR 0.05
HSL 1.0
PCR 15.0
PPR1_init 0.419998
ANMARL 0.86
AARK 1.0
ADHTC 15.0
O2CHMO 0.01
LPK 2.728e-14
CPF 0.0003
EXCXP2 0.17
PC_init 16.9144
OSV_init 0.694163
TSP_init 279.945
Z13 0.625
GFNLL 0.001
RNAUG3_init 0.0
AUMK1 0.3
AMKM 0.5
MDMP 0.0
ADHINF 0.0
AUC1 0.3
CN7 0.2
RFABDM 0.3
ANPINF 0.0
CN2 0.0212
AMM1T_init 1.00269
RCDFDP 2000.0
GCOPF 0.8092
ADHC 1.0
PLDF 4.2
O2A 0.1
ALDINF 0.0
VV7_init 0.00366525
RPS 0.0
Z16 5.0
ANMSLT 2.0
ALDKNS 0.0
RTPPR 0.9
AUDMP 0.3
ANMKEM 2.0
O2M 164.0
RTPPRS 15.2
POZ 2.0
RFN 1.22057
ANGINF 0.0
AMKMUL 12.0
AUSLP 1.5
AUTO 0.0

States:

Name Description
TVD(time) 0.000980838

Observables: none

guyton_volume_receptors_2008 @ v0.0.1

Guyton, Volume, Receptors, 2008

nothing

Parameters:

Name Description
Z 1.0
MDFL1 10.0
POK 0.1
MDFLKM 0.667
AMM1LM 0.005
VV9 2.51
KORREN 0.0
ANGKNS 0.0
AURG 1.0
ANMALD 2.5
DTKA_init 0.0367573
AUTOGN 7.0
ALDMM 2.5
TRPL 0.0
TSSLML 0.15
POM 0.04
EARK 1.0
SR 1.0
ANMAM 1.4
RFCDFT 0.0
ANMLL 0.7
ANPXUL 10.0
O2VAD1_init 2.368e-7
VID1 0.01
RFABDP 1.0
TVD_init 0.000980838
ADHVUL 2.5
PCE 1.0
ANMTM 1.5
VTSF 6.0
RCDFPC 0.0
ANMNAM 1.0
AUY 0.0
RNAULL 0.3
HM8 4.714e-8
PM5 30.0
RNAUAD 0.0
PAEX 2.0
ANPC_init 1.0
CPPD 31.9719
OMM 57.1
EXCXP 1.0
HMD1_init 1.0
RFABX 0.8
VIC_init 25.0404
AMM2_init 1.09071
KORTC 10000.0
GPPD 1.0
AUS 1.0
AUX 1.0
PO2AMB 150.0
AMNAM 0.8
AHMNAR 0.3
ANMEM 1.6
VNTSTM 1.0
KORNER 0.0
ADHC_init 1.0
Z14 5.0
HMK 90.0
AULPM 0.0
VPTISS 0.0175
Z12 5.0
AMC_init 1.0
AMNAUL 15.0
Z5 0.3
ADHPUL 85.0
CPR 40.0
VPF1_init 0.0123238
TRNSFS 0.0
TSSLTC 0.005
AUM1 3.0
AUMAX 5.0
RVSM 1.0
RABSC 0.5
RFABKM 0.03
QAOLM 0.2
GLPCA 1.0
AR3T_init 1.1448
TIMETR 0.0
AUM2 1.0
GFNDMP 3.0
VRA1_init 0.100043
X 4.0
AU6_init 1.00132
AH11 1000.0
RAPRSP 0.0
RMULT1 1.0
RNAUGN 0.6
CFC 0.01167
CV 0.1
ANULL 0.8
AR1T_init 1.02127
KID 0.08
CMPTSS 2.0
PON 0.1
AR2T_init 1.01179
ADHKUL 5.0
EARLL 24.0
PA4 1.0
DTNARL 1.0e-6
AH10 0.333
QRF 0.15
AMM4 0.005
DIURET 1.0
KTOT_init 3622.54
HKM 0.53333
SR2 1.0
SRK 5.0
MDFLW2 0.005
POM2 2.0
Z4 0.5
LPPR 0.03
RAM 96.3
CNR 139.0
Z6 20.0
ANUM 6.0
A3K 40000.0
PGHF -2.0
A4K 0.1
ANPXAF 1.5
ALCLK 0.3
ATRFBM 0.0
A4K2 40000.0
Z18 5.0
AUN1 0.5
ANY -0.2
URFORM 0.24
MDFLWX 0.01
QOM1_init 48.0839
VP_init 3.00449
AUV 0.55
REK 1.0
ANXM 0.0
VVS1_init 3.28246
OVA_init 204.497
VV6_init 0.0101913
AUTOSN 0.9
RNAUUL 10.0
HPL_init 1.00163
AARLL 4.0
ANPKNS 0.0
RVRS 19.167
ARF 0.5
STA 0.0
VP1 0.01
U 4.0
VRC_init 2.00439
A2K 60.0
TVDDL 30.0
VTW_init 39.8952
DTNAR 0.675
AHTHM 2.0
AMT 60.0
TRRBC 0.0
AMCSNS 0.65
KORGN 1.0
Z10 45.0
ANUVM 0.0
HM6 1850.0
AM1LL 0.0
OVS_init 0.699673
AHY_init 0.301963
ADHKLL 0.2
AUK 0.004
SRK2 10000.0
PXTP 8.0
VAS1_init 0.862514
PL2 1.8
CPK 0.000253
AM1UL 5.0
EXCML 0.01
AMNALL 0.04
BAROTC 0.16
AUL 1.5
RTSPRS 6.0
HPR_init 1.00237
Z7 5.0
HSR 1.0
AU4_init -0.060024
ANT 12.0
RKC 5.8e-6
FIS 0.0
EXC 1.0
PO2ADV 0.001
A1K 0.5
ANV 5000.0
PRP_init 216.243
RNAGTC 15.0
LPDE 8.0
AH9 1.0
ANCSNS 0.4
EXE 0.0
PK2 0.79167
ANC_init 0.859476
Z19 5.0
POR 35.0
VTS2_init 0.0
QO2T_init 72.2362
VLA1_init 0.379883
HTAUML 0.4
VIDML 0.01
ANMKEL 0.3
NID 0.1
AU1_init 1.00007
PR1LL 0.0
Z11 0.01
CRRFLX 0.0
TENSGN 0.0
TENSTC 0.05
ANMUL 1.8
RAR 30.52
CKEEX 4.0
ATRVM 0.0
ANX1_init 0.0
VPA1_init 0.38131
EFAFR 0.0
ANPTC 4.0
ADHPAM 0.3
DR 0.0
PAR1_init 103.525
HYL 60.0
GBL 0.0
PLUR_init 159.549
AR1LM 0.005
ADHVLL 0.93617
GFLC 0.0208333
AUMIN 0.4
NAE_init 2109.91
AR2LM 0.005
DHDTR 0.05
HSL 1.0
PCR 15.0
PPR1_init 0.419998
ANMARL 0.86
AARK 1.0
ADHTC 15.0
O2CHMO 0.01
LPK 2.728e-14
CPF 0.0003
EXCXP2 0.17
PC_init 16.9144
OSV_init 0.694163
TSP_init 279.945
Z13 0.625
GFNLL 0.001
RNAUG3_init 0.0
AUMK1 0.3
AMKM 0.5
MDMP 0.0
ADHINF 0.0
AUC1 0.3
CN7 0.2
RFABDM 0.3
PRA 0.00852183
ANPINF 0.0
CN2 0.0212
AMM1T_init 1.00269
RCDFDP 2000.0
GCOPF 0.8092
O2A 0.1
PLDF 4.2
ALDINF 0.0
VV7_init 0.00366525
RPS 0.0
Z16 5.0
ALDKNS 0.0
ANMSLT 2.0
RTPPR 0.9
AUDMP 0.3
ANMKEM 2.0
O2M 164.0
RTPPRS 15.2
POZ 2.0
RFN 1.22057
ANGINF 0.0
AMKMUL 12.0
AUSLP 1.5
AUTO 0.0

States:

Name Description
AHY(time) 0.301963

Observables: none

H


hai_murphy_1988 @ v0.0.1

Hai and Murphy 1988

nothing

Parameters:

Name Description
k3 0.4
k4 0.1
k7 0.01
k5 0.5
k2 0.5

States:

Name Description
AMp(time) 0.0
Mp(time) 0.0
M(time) 1.0
AM(time) 0.0

Observables: none

halloy_bernard_loussouarn_goldbeter_2002 @ v0.0.1

Halloy, Bernard, Loussouarn, Goldbeter, 2002

nothing

Parameters:

Name Description
mu_L 2.0
mu_Y 2.0
mu_Z 2.4
mu_A 3.6
eps_zero 0.0
T_init 0.33
mu_T 2.4
Y_init 0.33
M 0.0
epsilon 0.0
A_init 0.34
M_zero 0.0
L_init 0.33

States:

Name Description
M(time) 0.0
A(time) 0.34
T(time) 0.33
Y(time) 0.33
L(time) 0.33

Observables: none

hatakeyama_kimura_naka_kawasaki_yumoto_ichikawa_kim_saito_saeki_shirouzu_yokoyama_konagaya_2003 @ v0.0.1

Hatakeyama, Kimura, Naka, Kawasaki, Yumoto, Ichikawa, Kim, Saito, Saeki, Shirouzu, Yokoyama, Konagaya, 2003

nothing

Parameters: none

States: none

Observables: none

hatzimanikatis_lee_bailey_1999 @ v0.0.1

Hatzimanikatis, Lee, Bailey, 1999

nothing

Parameters:

Name Description
V4m 3.0
VdEm 1000.0
V3m 3000.0
K2 0.0001
thetaE 0.01
thetaI 1.0
KsE 0.1
V2m 40.0
V1m 50.0
sigma 10.0
K1C 0.1
K4 0.0001
Vsm 1.0
KdC 0.005
gamma 1.0
lambda 1.0
VCs 1.0
K3 0.0001
K1 0.0001

States:

Name Description
E(time) nothing
K(time) nothing
I(time) nothing
RP(time) nothing
C(time) nothing
R(time) nothing
KP(time) nothing

Observables: none

haugh_2004 @ v0.0.1

Haugh, 2004

nothing

Parameters:

Name Description
kx2 4.83
krec 0.0
R_initial 2000.0
ke 0.1
L 0.01
kdeg 0.05
k_x2 0.016
kf1 0.1
kappaE 0.2
kt 0.005
Vs 10.0
KD 1.0

States:

Name Description
R(time) nothing
C(time) 0.0
D(time) 0.0
Ri(time) nothing

Observables: none

heart @ v0.0.1

Heart Model

nothing

Parameters: none

States: none

Observables: none

heinze_keener_midgley_1998 @ v0.0.1

Heinze, Keener, Midgley, 1998

nothing

Parameters:

Name Description
kdf 2.52
a2 0.083
a1 0.0328
kbf 9.91
kfb 19.35
s 6.8
kbd 9.91

States:

Name Description
R(time) 2115.0
C(time) 0.0
D(time) 0.0
F(time) 1.0
B(time) 0.0

Observables: none

heldt_2002 @ v0.0.1

Heldt 2002

nothing

Parameters: none

States: none

Observables: none

herz_bonhoeffer_anderson_may_nowak_1996 @ v0.0.1

Herz, Bonhoeffer, Anderson, May, Nowak, 1996

nothing

Parameters:

Name Description
k nothing
a_ nothing
lamda nothing
u nothing
tau nothing
a nothing
beta nothing

States:

Name Description
vI(time) nothing
v(time) nothing
x(time) nothing
y(time) nothing

Observables: none

heyd_drew_2003 @ v0.0.1

Heyd, Drew, 2003

nothing

Parameters:

Name Description
k21 100.0
k72 60.0
kreset1 35.0
k71 0.1
k12 110.0
k52 0.0
PE2 0.1
k11_ 25.0
k31 500.0
k32 50.0
k41 60.0
k12_ 0.2
k22 100.0
k42 70.0
k21_ 0.2
k51 7.0
k22_ 17.0
k11 110.0

States:

Name Description
A2(time) 0.1
PE1(time) 0.1
PF2(time) 0.1
A1(time) 0.1
PG1(time) 0.1
PC2(time) 0.1
PF1(time) 0.1
PD1(time) 0.1
PC1(time) 0.1
PD2(time) 0.1
PB(time) 0.1

Observables: none

HH

HH @ v0.0.1

Andre's Hodgkin Huxley model

A version of the Hodgkin & Huxley (1952) model coded up by andre for demonstration purposes.

Parameters: none

States: none

Observables: none

hilgemann_noble_1987 @ v0.0.1

Hilgemann, Noble, 1987

nothing

Parameters:

Name Description
C_m 0.006
T 310.0
stim_start 0.1
alpha_Calmod 100000.0
alpha_Trop 100000.0
length 0.08
d_NaCa 0.0001
K_leak_rate 0.0
alpha_up 3.0
Cab 2.0
i_NaK_max 14.0
Trop 0.15
delta_f 0.0001
beta_up 0.23
K_cyca 0.0003
beta_Trop 200.0
K_mNa 40.0
g_b_K 0.17
g_K1 1.7
delta_m 1.0e-5
K_srca 0.5
V_e_ratio 0.4
g_b_Ca 0.005
Na_o 140.0
stim_duration 0.002
K_diff 0.0005
K_c 4.0
K_m_rel 250.0
n_NaCa 3.0
V_up_ratio 0.01
stim_period 1.0
stim_end 10000.0
alpha_tr 50.0
Calmod 0.02
radius 0.08
beta_Calmod 50.0
g_b_Na 0.012
K_xcs 0.4
delta_d 0.0001
V_rel_ratio 0.1
K_mK 1.0
P_si 5.0
g_Na 50.0
stim_amplitude -200.0
gamma 0.5
k_NaCa 0.01
K_m_K1 10.0
R 8314.472
F 96485.3415

States:

Name Description
d(time) 0.0011
Ca_Trop(time) 0.0015
Ca_rel(time) 0.3
V(time) -88.0
h(time) 0.015
K_i(time) 140.0
ProdFrac(time) 0.0
ActFrac(time) 0.0
f_Ca(time) 0.785
m(time) 0.076
Ca_up(time) 0.3
Ca_o(time) 2.0
Ca_i(time) 1.0e-5
Na_i(time) 6.5
Ca_Calmod(time) 0.0005

Observables: none

hinch_greenstein_tanskanen_xu_winslow_2004 @ v0.0.1

Hinch, Greenstein, Tanskanen, Xu, Winslow, 2004

nothing

Parameters:

Name Description
k_m_TRPN 0.04
c 0.01
T 295.0
B_CMDN 0.05
K_L 0.00022
d 100.0
theta_R 0.012
k_sat 0.1
K_mNa 87.5
eta 0.35
J_L 0.000913
V_L -2.0
J_R 0.02
V_myo 25840.0
del_VL 7.0
K_mCa 1.38
tau_R 2.43
phi_R 0.05
Na_o 140.0
b 14.0
B_TRPN 0.07
Ca_o 1.0
K_mpCa 0.0005
V_SR 2098.0
g_pCa 3.5e-6
k_CMDN 0.002382
a 0.0625
g_D 0.065
N 50000.0
g_NCX 0.0385
A_cap 15340.0
k_p_TRPN 40.0
K_SERCA 0.0005
g_SERCA 0.00045
tau_L 650.0
K_RyR 0.041
phi_L 2.35
g_CaB 2.6875e-8
g_SRl 1.8951e-5
t_L 1.0
R 8314.5
F 96487.0
Na_i 10.0

States:

Name Description
z_1(time) 0.98859
z_3(time) 0.0026566
TRPN(time) 0.0636364
Ca_SR(time) 0.7
Ca_i(time) 0.0001
z_2(time) 0.0087302

Observables: none

hodgkin_huxley_1952 @ v0.0.1

Hodgkin, Huxley, 1952

nothing

Parameters:

Name Description
E_R 0.0
g_K 36.0
g_Na 120.0
g_L 0.3
Cm 1.0

States:

Name Description
V(time) 0.0
h(time) 0.6
m(time) 0.05
n(time) 0.325

Observables: none

hoefnagel_starrenburg_martens_hugenholtz_kleerebezem_vanswam_bongers_westerhoff_snoep_2002 @ v0.0.1

Hoefnagel, Starrenburg, Martens, Hugenholtz, Kleerebezem, Vanswam, Bongers, Westerhoff, Snoep, 2002

nothing

Parameters:

Name Description
P 10.0
O 0.2
Ki_P 2.6
Km_P 2.6
Km_ADP 0.04699
Keq 9.0e12
V_NOX_max 118.0
Km_AC 7.0
Km_NAD 0.1412
Ki_COA 0.029
Ki_ACCOA 0.2
Km_COA 0.008
V_ACK_max 2700.0
Km_ACLAC 10.0
AC 0.01
V_ADH_max 162.0
NAD_tot 10.0
V_ACETEFF_max 200.0
V_ALS_max 600.0
Km_O 0.2
Km_ACP 0.7
BUT 0.01
Km_ATP 0.01867
A_tot 5.0
GLC 15.0
Km_PYR 2.5
Ki 46.4159
V_PDH_max 259.0
Ki_ACP 0.2
Km_ACAL 10.0
N 2.4
Km_GLC 0.1
V_ATPase_max 900.0
V_ACALDH_max 97.0
Km_ETOH 1.0
V_GLYC_max 2397.0
Km_NADH 0.08999
Km_ACET 100.0
k 0.0003
C_tot 1.0
Km_BUT 2.6
V_ACETDH_max 105.0
Km_LAC 100.0
LAC 0.1
V_PTA_max 42.0
ETOH 0.1
V_ALDC_max 106.0
V_LDH_max 5118.0
Km_ACCOA 0.007

States:

Name Description
ACLAC(time) 1.0e-5
ACCOA(time) 0.11
PYR(time) 1.0
ACET(time) 1.0e-5
ACP(time) 0.03145
ATP(time) 0.1
NADH(time) 3.67
ACAL(time) 0.11

Observables: none

holmes_2006 @ v0.0.1

Holmes 2006

nothing

Parameters:

Name Description
Po 144.9
alpha 1449.027
b 0.325
a 37.24
L_se_o 0.3

States:

Name Description
L_ce(time) 0.7

Observables: none

hornberg_binder_bruggeman_schoeberl_heinrich_westerhoff_2005 @ v0.0.1

Hornberg, Binder, Bruggeman, Schoeberl, Heinrich, Westerhoff, 2005

nothing

Parameters:

Name Description
kd24 0.55
k18 2.5e-5
k40 5.0e-5
kd3 0.01
kd35 0.0015
kd25 0.0214
kd126 2.0
k61 0.00067
kd44 0.0183
kd34 0.03
kd47 2.9
kd2 0.1
kd45 3.5
k53 0.0
kd36 0.0
k16 1.66e-5
kd56 0.6
k43 0.0
k127 0.0
k3 1.0
kd50 0.5
k28 1.66e-6
k42 0.000118
kd49 0.0568
kd13 0.0
k20 3.5e-6
kd4 0.00166
k13 2.17
k35 7.5e-6
kd127 0.0001
kd43 1.0
k126 1.66e-7
k45 0.0
k19 1.66e-7
k57 0.0
k22 3.5e-5
kd21 0.023
kd28 0.0053
k6 0.0005
kd29 1.0
kd10 0.011
kd1 0.00384
kd41 0.0429
kd37 0.3
kd17 0.06
k50 4.5e-7
k48 2.38e-5
k2 1.66e-5
kd48 0.8
kd23 0.06
k25 1.66e-5
k52 8.91e-5
kd8 0.2
k29 1.17e-6
kd57 0.246
k8 1.66e-6
k49 0.0
kd32 0.1
kd52 0.033
kd22 0.1
k37 1.5e-6
k56 2.35e-5
kd63 0.275
k60 0.0055
k32 4.0e-7
k41 5.0e-5
k33 3.5e-5
kd15 0.0
kd60 0.0
k17 1.66e-5
kd6 0.005
kd42 0.2
k21 3.66e-7
k58 8.33e-6
k47 0.0
k15 10000.0
kd55 5.7
kd53 16.0
k4 1.73e-7
kd40 0.064
kd20 0.4
k44 1.95e-5
k23 6.0
kd61 0.0
kd5 0.0146
kd33 0.2
k1 3.0e7
k10b 0.0543
kd19 0.5
k36 0.005
kd58 0.5
kd18 1.3
k55 0.0
k5 0.0
k34 7.5e-6

States:

Name Description
c20(time) 0.0
c97(time) 0.0
c33(time) 0.0
c26(time) 72000.0
c86(time) 0.0
c13(time) 0.0
c18(time) 0.0
c79(time) 0.0
c52(time) 0.0
c72(time) 0.0
c102(time) 0.0
c2(time) 50000.0
c55(time) 2.21e7
c81(time) 0.0
c23(time) 0.0
c53(time) 40000.0
c69(time) 0.0
c42(time) 0.0
c56(time) 0.0
c100(time) 0.0
c36(time) 0.0
c16(time) 0.0
c75(time) 0.0
c10(time) 0.0
c28(time) 0.0
c54(time) 0.0
c48(time) 0.0
c3(time) 0.0
c11(time) 0.0
c62(time) 0.0
c73(time) 0.0
c88(time) 0.0
c67(time) 0.0
c66(time) 0.0
c64(time) 0.0
c77(time) 0.0
c76(time) 0.0
c45(time) 0.0
c89(time) 0.0
c21(time) 0.0
c98(time) 0.0
c74(time) 0.0
c71(time) 0.0
c51(time) 0.0
c103(time) 0.0
c85(time) 0.0
c32(time) 0.0
c47(time) 2.1e7
c1(time) 5.0e-8
c96(time) 0.0
c38(time) 0.0
c40(time) 0.0
c29(time) 0.0
c68(time) 0.0
c91(time) 0.0
c24(time) 26300.0
c43(time) 0.0
c95(time) 0.0
c99(time) 0.0
c80(time) 0.0
c35(time) 0.0
c58(time) 0.0
c27(time) 0.0
c22(time) 11000.0
c44(time) 40000.0
c65(time) 0.0
c4(time) 0.0
c41(time) 40000.0
c15(time) 0.0
c84(time) 0.0
c59(time) 0.0
c30(time) 40000.0
c90(time) 0.0
c9(time) 0.0
c39(time) 0.0
c31(time) 101000.0
c63(time) 0.0
c12(time) 81000.0
c8(time) 0.0
c70(time) 0.0
c14(time) 12000.0
c7(time) 0.0
c34(time) 0.0
c93(time) 0.0
c83(time) 0.0
c5(time) 0.0
c61(time) 0.0
c94(time) 0.0
c78(time) 0.0
c92(time) 0.0
c101(time) 0.0
c19(time) 0.0
c57(time) 0.0
c17(time) 0.0
c82(time) 0.0
c87(time) 0.0
c46(time) 0.0
c37(time) 0.0
c25(time) 0.0
c60(time) 1.0e7
c49(time) 0.0
c6(time) 0.0
c50(time) 0.0

Observables: none

houart_dupont_goldbeter_1999 @ v0.0.1

Houart, Dupont and Goldbeter 1999

nothing

Parameters:

Name Description
n 4.0
zero 0.0
C 2.0
V_M5 5.0
K_d 0.4
k_f 1.0
one 1.0
V_M2 6.0
V_0 2.0
B 0.6
V_1 2.0
A_init 0.42
K_2 0.1
H 0.0
one_mm 1.0
V_4 2.0
K_5 1.0
K_A 0.2
K_Y 0.2
k 10.0
D 1.0
G 0.4
E 0.1
beta 0.6
I 2.0
J 4.0
m 2.0
V_M3 20.0
one_dm 1.0
epsilon 0.1
two 2.0
four 4.0
K_Z 0.5
Y_init 1.0
K 1.0
p 2.0
F 1.0

States:

Name Description
Z(time) 0.15
A(time) 0.42
Y(time) 1.0

Observables: none

huang_ferrell_1996 @ v0.0.1

Huang, Ferrell, 1996

nothing

Parameters:

Name Description
d8 150.0
d7 150.0
k10 150.0
k9 150.0
a2 1000.0
a1 1000.0
mapktot 1.2
k8 150.0
mostot 0.003
a7 1000.0
d9 150.0
k4 150.0
d6 150.0
a5 1000.0
k6 150.0
d2 150.0
e1tot 0.0003
a3 1000.0
d1 150.0
k1 150.0
a4 1000.0
d5 150.0
a6 1000.0
a10 1000.0
mapkpasetot 0.12
d10 150.0
mektot 1.2
k3 150.0
mekpasetot 0.0003
d3 150.0
k7 150.0
e2tot 0.0003
a8 1000.0
a9 1000.0
k5 150.0
d4 150.0
k2 150.0

States:

Name Description
mekstarmosstar(time) 0.0
mekstarmekpase(time) 0.0
mapkstar(time) 0.0
mek(time) 1.2
mapkstarmekstarstar(time) 0.0
mosstar(time) 0.0
mapkmekstarstar(time) 0.0
mekstarstar(time) 0.0
mapkstarstarmapkpase(time) 0.0
mekstar(time) 0.0
mekmosstar(time) 0.0
mapkstarstar(time) 0.0
mosstare2(time) 0.0
mekstarstarmekpase(time) 0.0
mos(time) 0.003
mose1(time) 0.0
mapk(time) 1.2
mapkstarmapkpase(time) 0.0

Observables: none

hund_rudy_2004 @ v0.0.1

Hund, Rudy, 2004

nothing

Parameters:

Name Description
prnak 0.01833
iupmax 0.004375
tissue 0.0
KmNao 87.5
Km 0.0015
KmBSR 0.00087
stim_offset 0.0
BSLmax 1.124
ibarpca 0.0575
GNaL 0.0065
kmko 1.5
KmCao 1.3
tbar 0.07
kmpca 0.0005
gitodv 0.19
Kmto2 0.1502
KmNai 12.3
eta 0.35
l 0.01
FonRT 0.0374358835078
nsrmax 15.0
CTNaClmax 9.8443e-6
dtau_rel_max 10.0
ksat 0.27
kmc 0.00238
NCXmax 4.5
Na_o 140.0
CTKClmax 7.0756e-6
stim_duration 3.0
ibarnak 0.61875
csqnbar 10.0
Kmup 0.00092
Ca_o 1.8
cbar 0.05
a 0.0011
stim_period 1000.0
kmt 0.0005
KmCa 0.000125
KmCaMK 0.15
gacai 1.0
K_o 5.4
gkr_const 0.0138542
gacao 0.341
dKmPLBmax 0.00017
kmnai 10.0
kmcsqn 0.8
KmBSL 0.0087
dJupmax 0.75
pca 0.000243
stim_amplitude -15.0
Cl_o 100.0
PCl 4.0e-7
BSRmax 0.047
GClb 0.000225
KmCai 0.0036
F 96485.0
CaMK0 0.05

States:

Name Description
Cl_i(time) 15.59207157178
xr(time) 7.24074e-6
fca2(time) 0.893052931249
Ca_ss(time) 0.00012271265
fca(time) 0.97836624923
dp(time) 8.98230672628
f(time) 0.999961508634
J(time) 0.991924983076
xs1(time) 0.019883138161
Ca_nsr(time) 1.832822335168
mL(time) 0.001356538159
m(time) 0.001356538159
xs2(time) 0.019890650554
ro(time) 0.0
Ca_jsr(time) 1.737580994071
Na_i(time) 12.972433387269
zdv(time) 0.829206149767
d(time) 1.64013e-6
V(time) -85.781844107117
f2(time) 0.992234519148
ydv(time) 0.013970786703
CaMKtrap(time) 0.021123704774
K_i(time) 135.469546216758
AA(time) 0.000816605172
ydv2(time) 0.99996472752
H(time) 0.987317750543
Ca_i(time) 0.00012131666
ri(time) 0.862666650318
hL(time) 0.26130711759

Observables: none

hunter_mcculloch_terkeurs_1998 @ v0.0.1

Hunter, Mcculloch, Terkeurs, 1998

nothing

Parameters:

Name Description
T_ref nothing
Ca_max nothing
rho_1 nothing
Ca_o nothing
tau nothing
pC_50_ref nothing
a nothing
A2 nothing
alpha_2 nothing
Ca_b_max nothing
lambda nothing
beta_0 nothing
alpha_3 nothing
n_ref nothing
tau_Ca nothing
rho_0 nothing
C_50 nothing
alpha_1 nothing
beta_2 nothing
beta_1 nothing
A3 nothing
A1 nothing
alpha_0 nothing

States:

Name Description
Ca_b(time) nothing
Ca_i(time) nothing
z(time) nothing
Q(time) nothing

Observables: none

hunter_mcnaughton_noble_1975 @ v0.0.1

Hunter, Mcnaughton, Noble, 1975

nothing

Parameters:

Name Description
Vm_plateau nothing
Vm_initial nothing
Vm_rest nothing
Istim nothing
Vm_threshold nothing
membrane_conductance nothing
Cm nothing

States:

Name Description
Vm(t) nothing

Observables: none

hunter_smaill_hunter_1995 @ v0.0.1

Hunter, Smaill, Hunter, 1995

nothing

Parameters: none

States: none

Observables: none

hynne_dano_sorensen_2001 @ v0.0.1

Hynne, Dano, Sorensen, 2001

nothing

Parameters:

Name Description
k18 24.7
V_5m 45.4327
V_8m 833.858
K10_ADP 0.17
K6_DHAP 2.0
V_12m 89.8023
K8_BPG 0.01
V_7m 116.365
V_15m 81.4797
V_10m 343.096
K2_IG6P 1.2
K10_PEP 0.2
K8_NADH 0.06
k9r 1528.62
K4_eq 0.13
k16 1.9
k0 0.048
P2 1.0
K6_FBP 0.3
K2_IIG6P 7.2
K2_Glc 1.7
K3_DGlc 0.37
V_6r 11039.1
K6_IGAP 10.0
K15_DHAP 25.0
K12_NADH 0.1
Glc_x_0 24.0
K8_GAP 0.6
k9f 443866.0
K6_eq 0.081
K15_NADH 0.13
k20 0.00283828
V_2m 1014.96
K7_DHAP 1.23
k13 16.72
K11 0.3
k24r 133.333
K6_GAP 4.0
K3_Glc 0.0
K15_INAD 0.13
K8_NAD 0.1
K15_INADH 0.034
k22 2.25932
V_6f 2207.82
K8_eq 0.0055
kappa5 0.15
K5 0.021
V_11m 53.1328
k23 3.2076
K4_G6P 0.8
V_3m 51.7547
CN_x_0 5.6
K7_GAP 1.27
K12_ACA 0.71
K3_ATP 0.1
k24f 432.9
K7_eq 0.055
y_vol 59.0
V_4m 496.042
K4_F6P 0.15

States:

Name Description
PEP(time) 0.04
G6P(time) 4.2
Glyc_x(time) 1.68478
ACA(time) 1.48153
ACA_x(time) 1.28836
AMP(time) 0.33
Pyr(time) 8.7
CN_x(time) 5.20358
ATP(time) 2.1
F6P(time) 0.49
FBP(time) 4.64
Glc(time) 0.573074
BPG(time) 0.00027
ADP(time) 1.5
Glyc(time) 4.196
EtOH(time) 19.2379
GAP(time) 0.115
EtOH_x(time) 16.4514
NAD(time) 0.65
DHAP(time) 2.95
Glc_x(time) 6.7
NADH(time) 0.33

Observables: none

I


iancu_2007 @ v0.0.1

Iancu 2007

nothing

Parameters:

Name Description
R_Total 0.633
ATP 5000.0
AF56 500.0
Gi_Total 20.0
k_act1 2.5
k_PDE2 20.0
PDE4 0.005
k_reas 1210.0
Km_PDE2 50.0
AC_47_cyt 0.136
V_cell 3.8e-11
k_AC47_cyt 0.00108
AC_47_ecav 0.2
J_cav_cyt 7.5e-14
MW_AC47 130.0
AC_56 3.379
AF47 130.0
Km_PDE4 2.2
J_ecav_cyt 1.5e-17
Km_PDE3 0.08
K_L 0.386
k_PDE3 1.25
k_hydr 0.8
K_H 0.035
k_act2 0.05
PDE2 0.005
J_cav_ecav 7.5e-15
PDE3 0.0075
K_C 8.809
Gs_Total 10.0
k_PDE4 2.5
MW_AC56 130.0
Km_ATP 315.0

States:

Name Description
RG(time) nothing
LR(time) nothing
Gi_beta_gamma(time) nothing
Gs_alpha_GDP(time) nothing
Gi_alpha_GTP(time) nothing
Gs_alpha_GTP(time) nothing
Gi_alpha_GDP(time) nothing
cAMP_cav(time) nothing
cAMP_cyt(time) nothing
cAMP_ecav(time) nothing
LRG(time) nothing
R(time) nothing
Gs_beta_gamma(time) nothing

Observables: none

iber_maini_2002 @ v0.0.1

Iber, Maini, 2002

nothing

Parameters:

Name Description
Ag_min nothing
f nothing
M21 nothing
k nothing
h nothing
beta nothing
m nothing
u nothing
M22 nothing
k_on nothing
n nothing

States:

Name Description
Cs(time) nothing
B1(time) nothing
AFC(time) nothing
M(time) nothing
Ag(time) nothing
C(time) nothing
C2(time) nothing
M2(time) nothing
C1(time) nothing
Ab(time) nothing
B(time) nothing
K_AgAb(time) nothing
Cs2(time) nothing
Cs1(time) nothing
B2(time) nothing
M1(time) nothing

Observables: none

inada_2009 @ v0.0.1

Inada 2009

nothing

Parameters:

Name Description
alpha_achf 73.1
K3ni 26.44
T 310.0
K_ACh 0.00035
C 4.0e-5
stim_start 0.1
inact_shift -5.0
K1ni 395.3
g_to 0.0
Kcni 26.44
Qco 0.0
g_ACh_max 0.0198
Kco 3.663
g_K1 0.0
delta_m 1.0e-5
tau_tr 0.06
g_Kr 0.0035
P_rel 1500.0
Kc 5.4
ACh 0.0
g_b 0.0012
stim_duration 0.001
K1no 1628.0
K_up 0.0006
I_p 0.14268
Cao 2.0
E_b -22.5
V_cell 3.18872e-6
K2no 561.4
Ki 140.0
Qn 0.4315
g_st 0.0001
stim_period 1.0
stim_end 99999.0
alpha_achs 3.7
K3no 4.663
act_shift -15.0
K2ni 2.289
slope_factor_act -5.0
E_CaL 62.0
Qci 0.1369
Nao 140.0
Kci 0.0207
E_st -37.4
g_Na 0.0
g_f 0.001
Nai 8.0
stim_amplitude -2.0
kNaCa 2.14455
g_CaL 0.009
R 8314.472
F 96485.3415

States:

Name Description
qa(time) 0.476404610622697
q_fast(time) 0.899732315818241
Casub(time) 0.000160310601192365
y(time) 0.0462303183096481
f(time) 0.975550840189597
paf(time) 0.192515363116553
f_CMs(time) 0.0630771339141488
pas(time) 0.0797182955833868
m(time) 0.143642247226618
d(time) 0.00179250298710316
f_TMM(time) 0.491718960234865
Ca_rel(time) 0.296249516481577
h2(time) 0.0157156121147801
f_CQ(time) 0.261430602900137
f2(time) 0.774394220125623
V(time) -49.7094187908202
achf(time) 0.550559577208797
f_CMi(time) 0.0723007987059414
r(time) 0.0296516611999521
f_TC(time) 0.0356473236675985
achs(time) 0.567277036232041
qi(time) 0.542303657353244
h1(time) 0.0243210273637729
f_CSL(time) 4.1497704886823e-5
Ca_up(time) 1.11092514657408
Cai(time) 0.000184969821581882
pik(time) 0.949023698965401
q_slow(time) 0.190111737767474
f_TMC(time) 0.443317425115817

Observables: none

international_si_units_2006 @ v0.0.1

International, Si, Units, 2006

nothing

Parameters: none

States: none

Observables: none

iribe_kohl_noble_2006 @ v0.0.1

Iribe, Kohl, Noble, 2006

nothing

Parameters:

Name Description
f_XB 10.0
alpha_trpn 80000.0
beta_trpn 200.0
stim_start 0.0
T 310.0
V_max_f 0.292
gain_k3 1.0
i_NaCa_max 0.0005
K_leak_rate 0.0
i_Kmax 1.0
gain_k2 1.0
i_NaK_max 1.36
SL 2.15
alpha_cmdn 10000.0
beta_cmdn 500.0
g_to 0.005
Cmdn_tot 0.02
Cm 9.5e-5
Trpn_tot 0.07
zeta 0.1
K_mNa 21.7
g_b_K 0.0006
g_K1 1.0
delta_m 1.0e-5
g_XB 30.0
g_b_Ca 0.00025
beta_tm 40.0
Na_o 140.0
stim_duration 0.002
speed_d 3.0
K_rel_max 500.0
gain_k4 1.0
Ca_o 2.0
P_Ca_L_Ca 0.25
shift_h 0.0
stim_period 0.5
stim_end 1000.0
K_mk1 10.0
gain_k1 1.0
K_o 4.0
g_b_Na 0.0006
V_max_r 0.391
v_i 1.6404e-5
K_mK 1.0
g_Na 2.5
speed_f 0.5
Tau_CaMK 0.8
stim_amplitude -4.0
v_SR 3.3477e-6
gamma 0.5
R 8314.472
Tau_SRCa_RyR 0.05
F 96485.3415

States:

Name Description
F_2(time) 8.7508e-6
x(time) 0.051127
f(time) 1.0
F_SRCa_RyR(time) 0.25089
P_1(time) 0.00013331
m(time) 0.0013809
P_3(time) 0.00015349
s(time) 0.95854
Na_i(time) 5.8041
P_0(time) 9.8593e-5
d(time) 1.7908e-8
V(time) -92.849333
h(time) 0.99569
K_i(time) 138.22
F_1(time) 0.5268
Cmdn_Ca(time) 3.9636e-6
r(time) 1.5185e-8
Trpn_Ca(time) 0.00027661
Ca_SR(time) 0.24886
F_CaMK(time) 1.028
Ca_i(time) 9.91e-6
N_0(time) 0.99917
P_2(time) 0.00023505

Observables: none

irvine_jafri_winslow_1999 @ v0.0.1

Irvine, Jafri, Winslow, 1999

nothing

Parameters:

Name Description
delta_H_v 121900.0
delta_H_cf 57533.0
delta_S_eta 338.915
z_alpha 0.0
delta_S_alpha 224.114
delta_S_beta 708.146
T 286.0
delta_S_v 193.265
delta_H_of 79035.0
delta_S_delta 229.205
delta_H_gamma_gamma -99967.0
delta_S_on 39.295
delta_S_of 1.51
delta_S_gamma 529.952
delta_H_delta_delta 62555.0
z_cf 0.0
delta_H_alpha 116900.0
delta_S_cn 786.217
z_of 0.0
z_delta_delta -3.5596
z_on 0.6625
delta_S_delta_delta -130.639
E_Na 0.044675
delta_H_delta 127970.0
delta_H_gamma 200240.0
delta_H_eta 150333.0
V -0.12
delta_S_cf 0.00711
delta_H_beta 263870.0
delta_S_omega 225.175
a 2.5218
h 6.62607095e-31
delta_S_gamma_gamma -578.317
z_cn 0.0
z_eta 1.5717
z_epsilon 0.0
delta_H_cn 293270.0
z_gamma 1.5703
z_omega 0.0
z_delta -1.3266
z_beta -0.9701
k 1.3806504e-23
g_Na 0.0131
delta_H_epsilon 79183.0
z_gamma_gamma 0.0
delta_H_omega 123020.0
delta_S_epsilon 70.078
delta_H_on 62385.0
R 8.314472
z_v -1.3281
F 96500.0

States:

Name Description
C3I(time) 0.0
C1I(time) 0.0
C0I(time) 0.0
C2I(time) 0.0
I(time) 0.0
C4I(time) 0.0
C2(time) 0.0
C0(time) 1.0
O2(time) 0.0
C1(time) 0.0
C3(time) 0.0
O1(time) 0.0
C4(time) 0.0

Observables: none

itskov_ehret_mavrilas_2006 @ v0.0.1

Itskov, Ehret, Mavrilas, 2006

nothing

Parameters: none

States: none

Observables: none

iyer_hajjar_armoundas_2007 @ v0.0.1

Iyer, Hajjar, Armoundas, 2007

Mechanisms of Abnormal Calcium Homeostasis in Mutations Responsible for Catecholaminergic Polymorphic Ventricular Tachycardia

Parameters:

Name Description
kryr 1.0
HTRPNtot 0.14
B2_HERG 0.02617412715118
f4Kv43 142.936645351
aaKv43 0.028983
GK1 0.125305126118808
Temp 310.0
B0_HERG 0.03304608038835
KmpCa 0.0005
HmaxC1O1 0.5
RyR2 0.0
stim_offset 100.0
b3Kv14 0.63902768758
betai0Kv14 2.44936e-6
Ko 4.0
tautr 0.5747
KvScale 0.872
B4_HERG 0.00568908859717
betai0Kv43 0.000819482
kcminus 0.0008
b4Kv14 2.12035379095
eta 0.35
aL 2.0
aiKv43 0.000373016
Faraday 96.5
B5_HERG -0.04536642959543
Kfb 0.000168
baKv43 0.0468437
Nfb 1.2
vmaxr 0.000318
GKr 0.0186
f2Kv14 17.51885408639
ksat 0.2
LTRPNtot 0.07
KmCMDN 0.00238
Kv43Frac 0.889
v1 1.8
baKv14 0.07793378174
Cao 2.0
alphaa0Kv43 0.543708
A6_HERG 8.039374403e-5
kltrpn_minus 0.04
vmaxf 7.48e-5
KmCa 1.38
KmEGTA 0.00015
b2Kv14 1.17100540567
Nrb 1.0
Rgas 8.315
kcplus 0.1
mcoop 3.0
A0_HERG 0.017147641733086
A3_HERG 0.00134366604423
Nao 138.0
Krb 3.29
GNab 0.001
KmCSQN 0.8
b1Kv43 6.77348
stim_amplitude -15.0
T_Const_HERG 5.320000001
VNSR 2.1e-6
B1_HERG -0.0430605416398
kNaCa 0.44
KSR 1.2
f4Kv14 54749.194733326
VSS 1.2e-9
GNa 56.32
ncoop 4.0
f3Kv14 938.58764534556
alphaa0Kv14 1.84002414554
tauxfer 26.7
kltrpn_plus 40.0
b4Kv43 524.576206679
A2_HERG 0.02057448605977
CMDNtot 0.05
betaa0Kv14 0.0108174834
KmKo 1.5
kaplus 0.01215
HN 2.5
A1_HERG 0.03969328381141
KmNai 20.0
khtrpn_plus 20.0
f2Kv43 14.224647456
kbminus 1.93
f3Kv43 158.574378389
khtrpn_minus 6.6e-5
Acap 0.0001534
A5_HERG 0.00646393910049
Pscale 7.0
kaminus 0.576
biKv43 5.374e-8
alphai0Kv43 0.0498424
B3_HERG -0.02691385498399
GCab 7.684e-5
CSQN2 0.0
bL 2.0
f1Kv14 0.52465073996
H50O1C2 1.0
gL 4.0
stim_duration 3.0
INaKmax 2.387
B6_HERG 6.9808924e-7
kbplus 0.00405
TNa 294.16
Vmyo 2.584e-5
GKs 0.0035
iso 0.0
stim_period 500.0
EGTAtot 0.0
b3Kv43 28.7532603313
IpCamax 0.05
b1Kv14 1.00947847105
KmNa 87.5
Hmin 5.0
A4_HERG 0.10666316491288
H50C1O1 1.0
ICahalf -0.265
VJSR 1.6e-7
betaa0Kv43 0.080185
HmaxC2O1 0.5
f1Kv43 1.8936
b2Kv43 15.6212705152
alphai0Kv14 0.00305767916
fL 0.3
aaKv14 0.00768548031

States:

Name Description
CCa2(time) 0.000943745917866092
CI2Kv43(time) 0.00428471710061031
na9(time) 0.312463212648791
C0(time) 0.465679150104636
CI2Kv14(time) 0.0567396669678271
na6(time) 1.02118700961583e-7
C3(time) 1.6747092904465e-7
C3Kv14(time) 0.000676403999474111
C0Kv14(time) 0.149374350989705
C0Kv43(time) 0.908189132330738
na1(time) 0.111284526171411
CCa3(time) 1.12741202215634e-5
C1_RyR(time) 0.132070890861418
HTRPNCa(time) 0.99347761599363
na3(time) 0.00779692701457915
CCa0(time) 0.489846779190386
C3Kv43(time) 3.11550715247964e-6
CaSS(time) 0.000506604278037024
Nai(time) 9.85573275838928
na4(time) 0.000561699600929369
C1Herg(time) 0.994948338598163
OKv14(time) 3.85187206387239e-5
LTRPNCa(time) 0.280466039150394
O2_RyR(time) 3.11350788541838e-7
CI3Kv43(time) 0.000564724236640674
V(time) -86.7261544519706
OIKv14(time) 0.556269044084734
CaJSR(time) 0.421936980515042
C1(time) 0.00834457719966281
C1Kv14(time) 0.0606794865684932
na12(time) 0.000750073829883749
CaNSR(time) 0.423551621440241
C2Kv43(time) 0.000487654173162347
Cai(time) 0.000363968672182656
IHerg(time) 0.000243789721526602
O2ks(time) 0.0258818770122187
OKv43(time) 7.42911977991342e-9
C2(time) 5.60736209083906e-5
O1_RyR(time) 0.00113684728532807
CI1Kv14(time) 0.00952432663172288
C2Herg(time) 0.000595653663190548
C2Kv14(time) 0.00930314185504921
C4(time) 1.87571666668874e-10
na2(time) 0.0481019786429977
OIKv43(time) 2.19603439704397e-5
C0ks(time) 0.938064990549233
O1ks(time) 5.65460174551007e-7
C2_RyR(time) 0.866791951404883
na11(time) 0.0140431688972267
Open(time) 1.40806027419488e-11
CI0Kv14(time) 0.0442722560882536
C3Herg(time) 0.000228183228829573
CCa1(time) 0.035111008610982
OHerg(time) 0.00120284688677794
na8(time) 0.368582741846592
yCa(time) 0.995434385054729
CCa4(time) 5.05056944609524e-8
na7(time) 1.93499158844817e-8
Ki(time) 125.427082712469
CI3Kv14(time) 0.113122845136053
C1Kv43(time) 0.0343385704915328
C1ks(time) 0.0360525668093578
na10(time) 0.0993398770493615
CI1Kv43(time) 0.0171163265867255
na13(time) 0.0370604970714329
CI0Kv43(time) 0.0349937004781012
na5(time) 1.51746424723121e-5

Observables: none

iyer_mazhari_winslow_2004 @ v0.0.1

Iyer, Mazhari, Winslow, 2004

nothing

Parameters:

Name Description
HTRPNtot 0.14
B2_HERG 0.02617412715118
f4Kv43 142.936645351
aaKv43 0.028983
GK1 0.12530512611880798
Temp 310.0
B0_HERG 0.03304608038835
KmpCa 0.0005
stim_offset 0.0
betai0Kv14 2.44936e-6
b3Kv14 0.63902768758
Ko 4.0
tautr 0.5747
KvScale 0.872
B4_HERG 0.00568908859717
betai0Kv43 0.000819482
kcminus 0.0008
b4Kv14 2.12035379095
eta 0.35
aL 2.0
aiKv43 0.000373016
Faraday 96.5
B5_HERG -0.04536642959543
Kfb 0.000168
baKv43 0.0468437
Nfb 1.2
vmaxr 0.000318
GKr 0.0186
f2Kv14 17.51885408639
ksat 0.2
LTRPNtot 0.07
KmCMDN 0.00238
Kv43Frac 0.889
v1 1.8
baKv14 0.07793378174
Cao 2.0
alphaa0Kv43 0.543708
A6_HERG 8.039374403e-5
kltrpn_minus 0.04
vmaxf 7.48e-5
KmCa 1.38
KmEGTA 0.00015
b2Kv14 1.17100540567
Nrb 1.0
Rgas 8.315
kcplus 0.1
mcoop 3.0
A0_HERG 0.017147641733086
A3_HERG 0.00134366604423
Nao 138.0
Krb 3.29
GNab 0.001
KmCSQN 0.8
b1Kv43 6.77348
stim_amplitude -15.0
T_Const_HERG 5.320000001
VNSR 2.1e-6
B1_HERG -0.0430605416398
kNaCa 0.44
KSR 1.2
f4Kv14 54749.19473332601
VSS 1.2e-9
GNa 56.32
ncoop 4.0
f3Kv14 938.58764534556
alphaa0Kv14 1.84002414554
tauxfer 26.7
kltrpn_plus 40.0
b4Kv43 524.576206679
A2_HERG 0.02057448605977
CMDNtot 0.05
betaa0Kv14 0.0108174834
KmKo 1.5
kaplus 0.01215
A1_HERG 0.03969328381141
CSQNtot 15.0
KmNai 20.0
khtrpn_plus 20.0
f2Kv43 14.224647456
kbminus 1.93
f3Kv43 158.574378389
khtrpn_minus 6.6e-5
Acap 0.0001534
A5_HERG 0.00646393910049
Pscale 7.0
kaminus 0.576
biKv43 5.374e-8
alphai0Kv43 0.0498424
B3_HERG -0.02691385498399
GCab 7.684e-5
bL 2.0
f1Kv14 0.52465073996
gL 4.0
stim_duration 3.0
INaKmax 2.387
B6_HERG 6.9808924e-7
kbplus 0.00405
TNa 294.16
Vmyo 2.584e-5
GKs 0.0035
stim_period 1000.0
EGTAtot 0.0
b3Kv43 28.7532603313
IpCamax 0.05
b1Kv14 1.00947847105
KmNa 87.5
A4_HERG 0.10666316491288
ICahalf -0.265
VJSR 1.6e-7
betaa0Kv43 0.080185
b2Kv43 15.6212705152
f1Kv43 1.8936
alphai0Kv14 0.00305767916
fL 0.3
aaKv14 0.00768548031

States:

Name Description
CCa2(time) 0.0001260326488
CI2Kv43(time) 0.0009918373359
na9(time) 0.2707214097
C0(time) 0.8621934054
CI2Kv14(time) 0.02287858869
na6(time) 1.57442749e-8
C3(time) 1.25021357e-7
C3Kv14(time) 0.000916070135
C0Kv14(time) 0.5977099765
C0Kv43(time) 0.9513721351
na1(time) 0.1437575649
CCa3(time) 1.112315238e-6
C1_RyR(time) 0.4448038946
HTRPNCa(time) 0.9772152481
na3(time) 0.004552898364
CCa0(time) 0.1198547081
C3Kv43(time) 1.311837579e-6
CaSS(time) 0.0001420215245
Nai(time) 9.798304162
na4(time) 0.000220520743
C1Herg(time) 0.996697338
OKv14(time) 1.975541357e-5
LTRPNCa(time) 0.08046584973
O2_RyR(time) 3.97392006e-9
CI3Kv43(time) 9.514386057e-5
V(time) -90.65755929
OIKv14(time) 0.1134082058
CaJSR(time) 0.2852239446
C1(time) 0.01141398211
C1Kv14(time) 0.1730990528
na12(time) 0.0001957874519
CaNSR(time) 0.2855294915
C2Kv43(time) 0.0002806380358
Cai(time) 8.601192016e-5
IHerg(time) 1.533347007e-6
O2ks(time) 1.298547822e-5
OKv43(time) 2.29955624e-9
C2(time) 5.666325225e-5
O1_RyR(time) 0.0006601783287
CI1Kv14(time) 0.005428824353
C2Herg(time) 0.0004340879648
C2Kv14(time) 0.01881072386
C4(time) 1.034426748e-10
na2(time) 0.0417776208
OIKv43(time) 2.742677382e-6
C0ks(time) 0.9645606295
O1ks(time) 2.491710696e-7
C2_RyR(time) 0.554535924
na11(time) 0.005496292279
Open(time) 7.757981563e-12
CI0Kv14(time) 0.03539084346
C3Herg(time) 7.634099755e-5
CCa1(time) 0.006346794302
OHerg(time) 9.511789113e-6
na8(time) 0.4749950008
yCa(time) 0.9997157074
CCa4(time) 3.681315892e-9
na7(time) 2.856607179e-9
Ki(time) 125.5589432
CI3Kv14(time) 0.03233800003
C1Kv43(time) 0.02668288089
C1ks(time) 0.03542613568
na10(time) 0.05786120057
CI1Kv43(time) 0.005442964601
na13(time) 0.000417679396
CI0Kv43(time) 0.01513025204
na5(time) 4.005266484e-6

Observables: none

izakov_katsnelson_blyakhman_markhasin_shkylar_1991 @ v0.0.1

Izakov, Katsnelson, Blyakhman, Markhasin, Shkylar, 1991

nothing

Parameters:

Name Description
a_c 0.00024
q_3 0.03
t_d 170.0
a 0.25
pi_min 0.05
TnC 1.0
b_c 0.0005
alpha_2 14.6
S_0 0.77
q_1 0.017
g_2 0.6
lambda 30.0
C_20 0.2
Ca_m 0.045
alpha_1 14.6
m_0 0.87
g_1 0.4
q_2 0.26
beta_2 0.0012
beta_1 1.0
q_k 4.0
C_1 0.029
V_max 0.0043

States:

Name Description
n_2(time) 0.0
A_1(time) 0.0

Observables: none

J


jafri_rice_winslow_1998 @ v0.0.1

Jafri, Rice, Winslow, 1998

nothing

Parameters:

Name Description
k_a_minus 0.1425
stim_start 100.0
omega 0.01
k_b_minus 1.93
v3 0.0018
k_sat 0.1
K_mNa 87.5
eta 0.35
LTRPN_tot 0.07
A3 129.0
tau_tr 34.48
K_mCa 1.38
kon 100.0
nCa 4.0
k_a_plus 1.215e10
v1 1.8
b 2.0
Cao 1.8
g_Nab 1.41e-5
tau_xfer 3.125
alphar1 0.002
f_ 0.0
K_m_ns_Ca 0.0012
I_pCa 0.0115
k_ltrpn_minus 0.04
I_NaK 0.013
CSQN_tot 15.0
beta1 -4.0
Nao 140.0
nRel 3.0
K_mNai 10.0
gamma_trpn 2.0
g_Kp 8.28e-5
stim_amplitude -100.0
alphar2 0.00175
dlambdadt 0.0
K_mKo 1.5
F 96845.0
g_ 0.0
f 0.3
Tref 56.2
T 310.0
koff 0.2
Ca50ref 0.00105
nHill 3.0
K_mup 0.0005
k_htrpn_plus 20.0
Cm 0.01
k_htrpn_minus 6.6e-5
alpha0 0.008
P_ns_Ca 1.75e-9
g 2.0
P_NaK 0.01833
Am 546.69
alpha1 0.03
beta0 4.9
V_myo 0.92
k_b_plus 4.05e7
k_c_plus 0.018
g_K_max 0.001128
k_c_minus 0.0008
A1 -29.0
zp 0.85
g_K1_max 0.0075
stim_duration 1.0
Kz 0.15
alpha2 0.13
K_mpCa 0.0005
a 2.0
stim_period 750.0
stim_end 9000.0
A2 138.0
K_mCSQN 0.8
K_mCMDN 0.00238
lambda 1.0
alpha3 0.625
TRPN_tot 0.07
k_ltrpn_plus 40.0
CMDN_tot 0.05
HTRPN_tot 0.14
P_Ca 3.375e-5
g_Na 0.128
g_Cab 6.032e-5
v2 5.8e-5
k_NaCa 50.0
mCa 3.0
R 8314.5
P_K 1.0e-9
i_Ca_L_Ca_half -0.00458

States:

Name Description
P_C1(time) 0.762527
X(time) 0.000928836
Ca_NSR(time) 1.243891
C2(time) 1.535e-9
C0(time) 0.997208
y(time) 0.998983
P_C2(time) 0.236283
C3(time) 1.63909e-14
HTRPNCa(time) 0.13598
Ko(time) 5.4
O(time) 9.84546e-21
C_Ca0(time) 0.00272826
j(time) 0.99254
Ca_SS(time) 0.000136058
C_Ca3(time) 2.87031e-15
m(time) 0.0328302
C4(time) 6.56337e-20
Nai(time) 10.2042
Q1(time) 0.0
Cab(time) 0.0
LTRPNCa(time) 0.00635
C_Ca4(time) 4.59752e-20
V(time) -84.1638
h(time) 0.988354
C_Ca1(time) 6.99215e-7
z(time) 0.0
C1(time) 6.38897e-5
P_O1(time) 0.00119168
Ki(time) 143.727
Ca_JSR(time) 1.17504
O_Ca(time) 0.0
Cai(time) 9.94893e-11
C_Ca2(time) 6.71989e-11
P_O2(time) 6.30613e-9
Q2(time) 0.0
Q3(time) 0.0

Observables: none

jelic_cupic_kolaranic_2005 @ v0.0.1

Jelic, Cupic, Kolaranic, 2005

nothing

Parameters:

Name Description
alpha 0.008
k0 8.7831e-11
L 0.1
beta 1.485
k4 2.1e12
k3 4.8e-6
km 6.9001e-14
k7 0.006831
gamma 11.385
k6 0.000891
K 30.0
k2 0.0006

States:

Name Description
a(tau) 4.39927
g(tau) 1.96477

Observables: none

joseph_zavros_merchant_kirschner_2003 @ v0.0.1

Joseph, Zavros, Merchant, Kirschner, 2003

nothing

Parameters:

Name Description
gamma_DC nothing
f nothing
KNS nothing
N_ nothing
alpha_AS nothing
alpha_Csc nothing
Nmax1 nothing
alpha_Fd nothing
gamma_P nothing
alpha_NH nothing
alpha_GS nothing
hb nothing
beta_A nothing
kFd nothing
gamma_DA nothing
gamma_Fdmax nothing
Bas1 nothing
alpha_HA nothing
kSA nothing
KAS nothing
kappa_NC nothing
k_BCmax nothing
Bas2 nothing
Nmax2 nothing
C_Csc nothing
KNG1 nothing
gamma_E nothing
kNS nothing
alpha_NG2 nothing
gamma_Asc nothing
KGA nothing
k_gmax nothing
kG nothing
KHA nothing
alpha_GA nothing
alpha_NG1 nothing
KNG2 nothing
kappa_H nothing
beta_G nothing
k_dmax nothing
alpha_GH nothing
kSG nothing
KNH nothing
KNA nothing
kappa_NE nothing
kSS nothing
gamma_Csc nothing
KFG nothing
kappa_A nothing
kappa_G nothing
C_Asc nothing
kappa_S nothing
kAN2 nothing
KGH nothing
T_Asc nothing
kAN1 nothing
alpha_NS nothing
Fd nothing
gmax nothing
alpha_NA nothing
gamma_Gc nothing
T_Csc nothing
k_Emax nothing
KGS nothing
k_Fdmax nothing
alpha_NB nothing
beta_B nothing
kSH nothing
alpha_E nothing
kappa_B nothing
kAG nothing
k_BAmax nothing

States:

Name Description
P(time) nothing
DC(time) nothing
GtnA(time) nothing
BC(time) nothing
GtnC(time) nothing
Asc(time) nothing
NE(time) nothing
HC(time) nothing
AA(time) nothing
SA(time) nothing
SC(time) nothing
DA(time) nothing
E(time) nothing
BA(time) nothing
NC(time) nothing
Csc(time) nothing
G(time) nothing
AC(time) nothing

Observables: none

K


karagiannis_popel_2004 @ v0.0.1

Karagiannis, Popel, 2004

nothing

Parameters:

Name Description
kcat_M2C1 0.0045
kiso_M2T2 33.0
kon_MT1T2M2P 140000.0
kon_MT1T2 3.54e6
kshed_eff 2800.0
ki_M2T2 1.07e-6
kon_M2T2 5.9e6
kon_M2C1 2600.0
kcat_MT1C1 0.00197
km_MT1C1 2.9e-6
koff_M2C1 0.0021
kact_eff_m2 2800.0
k_iso_M2T2 2.0e-8
ki_MT1T2 4.9e-9
koff_MT1T2M2P 0.0047

States:

Name Description
M2T2star(time) 0.0
MT1cat(time) 0.0
M2T2(time) 0.0
M2(time) 0.0
M2P(time) 5.0e-8
C1(time) 1.0e-6
T2(time) 5.0e-8
MT1(time) 1.0e-7
C1dm2(time) 0.0
C1dmt1(time) 0.0
M2C1(time) 0.0
MT1T2M2P(time) 0.0
MT1T2(time) 0.0

Observables: none

karagiannis_popel_2006 @ v0.0.1

Karagiannis, Popel, 2006

nothing

Parameters:

Name Description
kM2T2_on 5.9e6
kMT1T2_on 2.98e6
kMT1C1_on 1000.0
kM2T2_negativeiso 2.0e-8
qMT1 0.0
kMT1T2M2proMT1_off 0.0009
kM2C1_off 0.0021
kM2C1_on 2600.0
kM2T2_off 6.3
kMT1_shedeff 2800.0
kMT1T2_off 0.202
kMT1C1_off 1.0
kMT1C1_cat 0.00197
kMT1T2M2pro_off 0.0047
kM2T2_iso 33.0
kMT1T2M2proMT1_on 3000.0
kM2_act 0.02
kM2C1_cat 0.0045
qT2 0.0
qpro 0.0
kMT1T2M2pro_on 140000.0

States:

Name Description
M2C1(t) 8.5e-6
MT1T2M2pro(t) 0.0
C1_D(t) 0.0
C1(t) 0.0
MT1_cat(t) 0.0
M2T2(t) 7.2e-9
MT1T2M2proMT1(t) 5.6e-10
M2_p(t) 0.0
M2T2_star(t) 0.0
MT1C1(t) 2.9e-6
MT1T2(t) 1.39e-9
MT1(t) 0.0
T2(t) 0.0
MT1_t(t) 0.0
MT1T2_star(t) 0.0
M2(t) 0.0

Observables: none

katsnelson_nikitina_chemla_solovyova_coirault_lecarpentier_markhasin_2004 @ v0.0.1

Katsnelson, Nikitina, Chemla, Solovyova, Coirault, Lecarpentier, Markhasin, 2004

nothing

Parameters:

Name Description
a_c 5200.0
alpha_P_lengthening 16.0
t_d 0.033
k_A 2.8
q_Ca 50.0
alpha_2 14.6
S_0 1.14
beta_P_lengthening 0.0015
a_on 2300.0
Ca_m 0.03
B_tot 0.4
m_0 0.9
r_Ca 650.0
beta_S_shortening 0.006
beta_2 0.000924
beta_Q 5000.0
beta_3 0.01
F_afterload 2.0
alpha_G 1.0
b_on 2600.0
alpha_S_shortening 46.0
A_tot 1.0
q_3 17.3
chi_0 3.0
a_off 290.0
a 0.25
mu 3.0
alpha_Q 10.0
l_0 0.527
v_star 5.3035675
chi 0.705
A_half 0.6
v_max 5.6
q_1 17.3
lambda 96.0
q_star 1000.0
alpha_3 48.0
isotonic 0.0
q_4 15.0
alpha_1 19.0
q_2 259.0
v_0 560.0
beta_P_shortening 0.0015
alpha_S_lengthening 39.0
alpha_P_shortening 16.0
b_off 182.0
beta_S_lengthening 0.008
beta_1 0.29
d_h 0.5
alpha_P 4.0

States:

Name Description
N(time) 0.0001
l_3(time) 0.089
A(time) 0.01
l_2(time) 0.439
v(time) 0.0
l_1(time) 0.437
w(time) 0.0
B(time) 0.0
Ca_C(time) 0.0

Observables: none

keener_2001 @ v0.0.1

Keener, 2001

nothing

Parameters: none

States: none

Observables: none

keizer_levine_1996 @ v0.0.1

Keizer, Levine, 1996

nothing

Parameters:

Name Description
kb_ 385.9
ka 1500.0
kc_ 0.1
c1 0.15
kc 1.75
fi 0.01
n 4.0
v1 40.0
Co 10.0
ka_ 28.8
m 3.0
v2 0.5
kb 1500.0
v3 1000.0
K3 0.3

States:

Name Description
P_O1(time) nothing
P_C1(time) nothing
P_C2(time) nothing
P_O2(time) nothing
Cai(time) nothing
w(time) nothing

Observables: none

kesmir_deboer_1999 @ v0.0.1

Kesmir, Deboer, 1999

nothing

Parameters:

Name Description
pr 0.15
SA 500.0
mu 3.0
rho 4.0
sigma 5.0
ST 50.0
delta_T 0.8
KB 10000.0
KT 100.0
u 0.15
z 0.02
delta_B 0.8
p 2.0
d 2.0

States:

Name Description
B10(time) 0.0
B9(time) 0.0
B1(time) 0.0
B5(time) 0.0
C_star(time) 0.0
B8(time) 0.0
M(time) 0.0
T(time) 0.0
B0(time) 3.0
C(time) 0.0
B3(time) 0.0
B7(time) 0.0
A(time) 500.0
B2(time) 0.0
B4(time) 0.0
B6(time) 0.0

Observables: none

kholodenko_demin_moehren_hoek_1999 @ v0.0.1

Kholodenko, Demin, Moehren, Hoek, 1999

nothing

Parameters:

Name Description
k14 6.0
k18 0.3
k25 1.0
k9 0.003
k15_ 0.0009
k6_ 0.05
k12_ 0.0001
k21_ 0.1
k10_ 0.06
K16 340.0
k1_ 0.06
k5_ 0.2
V8 1.0
k12 0.0015
K4 50.0
K8 100.0
k3 1.0
k17 0.003
k22_ 0.064
k20 0.12
k21 0.003
k10 0.01
k13 0.09
k18_ 0.0009
k7_ 0.006
k15 0.3
V16 1.7
k23_ 0.021
k20_ 0.00024
k19 0.01
k9_ 0.05
k14_ 0.06
k22 0.03
k13_ 0.6
k6 1.0
k11 0.03
k23 0.1
V4 450.0
k11_ 0.0045
k17_ 0.1
k3_ 0.01
k1 0.003
k2_ 0.1
k7 0.3
k24_ 0.0429
k25_ 0.03
k19_ 0.0214
k5 0.06
k24 0.009
k2 0.01

States:

Name Description
R_Sh_G(time) 0.0
EGF(time) 680.0
R_PL(time) 0.0
R2(time) 0.0
R_ShP(time) 0.0
Ra(time) 0.0
R_Sh_G_S(time) 0.0
Sh_G(time) 0.0
G_S(time) 0.0
R_G_S(time) 0.0
ShP(time) 0.0
Sh_G_S(time) 0.0
R_PLP(time) 0.0
RP(time) 0.0
PLC_gamma(time) 105.0
PLC_gamma_P_I(time) 0.0
SOS(time) 34.0
Grb(time) 85.0
PLC_gamma_P(time) 0.0
R_Sh(time) 0.0
R(time) 100.0
R_G(time) 0.0
Shc(time) 150.0

Observables: none

kirschner_panetta_1998 @ v0.0.1

Kirschner, Panetta, 1998

nothing

Parameters:

Name Description
mu3 10.0
s1 0.0
c 0.02
b 1.0e-9
mu2 0.03
s2 0.0
a 1.0
r2 0.18
p2 5.0
g2 100000.0
p1 0.1245
g1 2.0e-7
g3 1000.0

States:

Name Description
x(tau) 1.0
z(tau) 1.0
y(tau) 1.0

Observables: none

kirschner_webb_1996 @ v0.0.1

Kirschner, Webb, 1996

nothing

Parameters: none

States: none

Observables: none

kneller_ramirez_chartier_courtemanche_nattel_2002 @ v0.0.1

Kneller, Ramirez, Chartier, Courtemanche, Nattel, 2002

nothing

Parameters:

Name Description
T 310.0
TRPN_max 0.35
K_rel 30.0
Ca_up_max 15.0
g_Cl_Ca 0.3
V_rel 96.48
q_Ca 0.0
K_sat 0.1
delta_CT_n 87.8251
i_NaK_max 0.6
I_up_max 0.005
g_Ca 0.24
CMDN_max 0.045
g_B_Cl 0.0018
g_to 0.19824
Cm 100.0
g_B_K 0.0
Km_K_o 1.5
K_mNa 87.5
g_Ks 0.0561
g_K1 0.15
tau_tr 180.0
g_Kr 0.06984
I_NaCa_max 1600.0
K_mCa 1.38
Na_o 140.0
tau_q_Ca 2.0
K_up 0.00092
g_B_Na 0.000674
Ca_o 1.8
K_o 5.4
V_i 13668.0
i_stim -2900.0
g_Na 7.8
g_B_Ca 0.00113
g_CT 0.115
V_up 1109.52
i_p_Ca_max 0.275
CSQN_max 10.0
Cl_o 132.0
Km_Na_i 10.0
tau_f_Ca 2.0
R 8.3143
F 96.4867
n 4.0

States:

Name Description
Ca_CMDN(time) nothing
oa(time) nothing
oi(time) nothing
Cl_i(time) nothing
xr(time) nothing
v(time) nothing
xs(time) nothing
f(time) nothing
ui(time) nothing
u(time) nothing
j(time) nothing
m(time) nothing
Na_i(time) nothing
w(time) nothing
d(time) nothing
Ca_rel(time) nothing
V(time) nothing
h(time) nothing
ua(time) nothing
Ca_TRPN(time) nothing
K_i(time) nothing
Ca_CSQN(time) nothing
f_Ca(time) nothing
J_Ca_CSQN(time) nothing
Ca_up(time) nothing
Ca_i(time) nothing
J_Ca_TRPN(time) nothing
J_Ca_CMDN(time) nothing

Observables: none

koivumaki_2009 @ v0.0.1

Koivumaki,2009

nothing

Parameters:

Name Description
Kmf_PLB 0.15
Na_i 14000.0
C_m 1.0
T 298.0
PKA_reg 0.1
kltrpn_pos 0.1
SERCA_TOT 47.0
kplb_neg 6.8
Kmr_PLBKO 2500.0
Ca_cyt 0.25
Ca_NSR 760.0
eta 0.35
LTRPN_tot 70.0
V_myo 2.584e-5
Acap 0.0001534
Km_CaM 2.38
PLB_tot 1.0
A1 110.0
PSR 1.0
ksat 0.1
br_serca_sr 0.00625
Ca_pow 2.0
kplb_pos 1.0
Na_o 140000.0
Ca_tau1 1.5
Ca_tau2 14.0
CaM_tot 24.0
Ca_o 1000.0
rest -80.0
KmCa 1380.0
J_leak 0.0003
KmNa 87500.0
CaMKII_reg 0.0
A 150.0
Kmf_PLBKO 0.15
t2 8.0
kltrpn_neg 0.06
t1 0.5
Kmr_PLB 1110.0
kNaCa 950.0
Ca_amp 2.9
R 8.314
F 96.5
p 2.0

States:

Name Description
Ca_serca(time) 12.0
LTRPN(time) 11.0
Ca_cyt(time) 0.1
PLB_dephosph(time) 0.1

Observables: none

komarova_2005 @ v0.0.1

Komarova 2005

nothing

Parameters:

Name Description
g22 0.0
beta2 0.02
g12 1.0
alpha2 4.0
alpha1 3.0
g11 0.5
k1 0.24
beta1 0.2
k2 0.0017

States:

Name Description
x2(time) 212.132
z(time) 100.0
x1(time) 10.06066

Observables: none

komarova_smith_dixon_sims_wahl_2003 @ v0.0.1

Komarova, Smith, Dixon, Sims and Wahl, 2003

nothing

Parameters:

Name Description
g22 0.0
g21 -0.5
beta2 0.02
g12 1.0
alpha2 4.0
alpha1 3.0
g11 1.1
k1 0.093
beta1 0.2
k2 0.0008

States:

Name Description
x2(time) 212.132
z(time) 100.0
x1(time) 10.06066

Observables: none

komarova_wodarz_2003 @ v0.0.1

Komarova, Wodarz, 2003

nothing

Parameters:

Name Description
r_5 1.0
r_1 0.6
r_3 0.8
alpha 0.1
r_2 0.7
a 0.5
r_4 0.9
r_8 1.3
r_6 1.1
beta 0.2
rm 1.3
rs 1.0
epsilon_m 0.1
r_0 0.5
r_7 1.2
u 0.07
epsilon_s 0.99

States:

Name Description
S_6(time) 0.0
M_2(time) 0.0
M_0(time) 0.5
S_7(time) 0.0
M_4(time) 0.0
S_3(time) 0.0
S_1(time) 0.0
S_5(time) 0.0
w(time) 0.0
M_1(time) 0.0
S_4(time) 0.0
M(time) 0.5
M_7(time) 0.0
S_2(time) 0.0
M_3(time) 0.0
S_0(time) 0.5
M_1_2(time) 0.0
M_6(time) 0.0
M_8(time) 0.0
S(time) 0.5
M_5(time) 0.0
S_8(time) 0.0

Observables: none

kongas_vanbeek_2001 @ v0.0.1

Kongas, Vanbeek, 2001

nothing

Parameters:

Name Description
Vb 29250.0
R_ADP 8.16
Kia 900.0
V_hyd 4600.0
R_ATP 8.16
R_Cr 14.6
V_syn_max 4600.0
Kid 4730.0
Kic 222.4
R_PCr 14.6
V_cyt 0.75
KPi 20.0
Kib 34900.0
KADP 800.0
Kb 15500.0
R_Pi 18.4
Kd 1670.0
V_ims 0.0625
Vf 6966.0

States:

Name Description
PCr_i(time) 12500.0
Pi(time) 8000.0
PCr(time) 12500.0
Cr(time) 13500.0
ATP_i(time) 9644.425
ADP_i(time) 2.5
Cr_i(time) 13500.0
ATP(time) 9644.425
Pi_i(time) 8000.0
ADP(time) 60.0

Observables: none

korzeniewski_zoladz_2001 @ v0.0.1

Korzeniewski, Zoladz, 2001

nothing

Parameters:

Name Description
k_EFF 1.9258
kSN 34316.0
T 289.0
Ae_SUM 1600.2
nA 2.5
protonmotive_force 190.0
kC1 238.95
kPI 69.421
kDH 28074.0
Nt 2970.0
c_buffi 0.022
kL1 2.5
pKa 6.8
c_buffe 0.025
kL2 0.038
kUT 686.5
pD 0.8
KmO 120.0
km_A 150.0
Ai_SUM 16260.0
kDDi 282.0
pH_o 7.0
dpH 0.001
Mg_fi 380.0
C_SUM 35000.0
kDTi 17.0
kEX 54572.0
kDDe 347.0
R_cm 15.0
kC3 136.41
kf_CK 1.9258
EmU0 85.0
at 135.0
Ema0 540.0
BN 5.0
km_ADP 3.5
kf_AK 862.1
Mg_fe 4000.0
ct 270.0
kb_CK 0.00087538
KmN 100.0
kDTe 24.0
kC4 136.41
Emc0 250.0
kb_AK 22.747
delta_Gp0 31.9
R 0.0083
Ut 1350.0
EmN0 -320.0
F 0.0965

States:

Name Description
UQH2(time) 1.0
ATP_ti(time) 1.0
NADH(time) 500.0
Hi(time) 1.0
PCr(time) 1.0
ADP_te(time) 1.0
O2(time) 1.0
He(time) 1.0
Pi_te(time) 1.0
Pi_ti(time) 1.0
c_2(time) 1.0
a_2(time) 1.0
ATP_te(time) 1.0

Observables: none

kroll_2000 @ v0.0.1

Kroll, 2000

nothing

Parameters:

Name Description
C3 1.0
K2 2.0
C 50.0
k1 1.0
C1 1.0
C2 1.0
k4 0.9
k3 0.05
k6 0.02
K 5.0
k5 5.0
k2 1.3
ky 0.01

States:

Name Description
P(time) 10.0
Z(time) 200.0
X(time) 500.0
Y(time) 10.0
IL6(time) 1.9

Observables: none

kummer_2000 @ v0.0.1

Switching from Simple to Complex Oscillations in Calcium Signaling

We present a new model for calcium oscillations based on experiments in hepatocytes. The model considers feedback inhibition on the initial agonist receptor complex by calcium and activated phospholipase C, as well as receptor type-dependent self-enhanced behavior of the activated G(alpha) subunit. It is able to show simple periodic oscillations and periodic bursting, and it is the first model to display chaotic bursting in response to agonist stimulations. Moreover, our model offers a possible explanation for the differences in dynamic behavior observed in response to different agonists in hepatocytes.

Parameters:

Name Description
k14 153.0
k2 2.9259
k10 13.58
K11 2.67
k13 0.12
K15 0.16
k12 0.7
k16 4.85
k1 0.212
k8 32.24
K4 0.19
K17 0.05
k3 1.52
K9 29.09
k7 1.24
K12 0.16
k5 4.88
K6 1.18
k11 153.0

States:

Name Description
d(time) 20.0
b(time) 0.01
c(time) 0.01
a(time) 0.01

Observables: none

kurata_hisatome_imanishi_shibamoto_2002 @ v0.0.1

Kurata, Hisatome, Imanishi, Shibamoto, 2002

nothing

Parameters:

Name Description
K3ni 26.44
T 310.15
Km_fCa 0.00035
K_rel 0.0012
TC_tot 0.031
Km_Kp 1.4
kf_TC 88.8
g_h_Na 0.1437375
Km_Nap 14.0
V_rel 4.2223e-15
K1ni 395.3
i_NaK_max 3.6
Ko 5.4
g_to 0.18
Kcni 26.44
Cm 32.0
kb_TC 0.446
Qco 0.0
g_h_K 0.2312625
kf_TMM 2.277
Kco 3.663
g_Ks 0.0259
kf_CM 227.7
TMC_tot 0.062
tau_tr 60.0
g_sus 0.02
kf_CQ 0.534
P_rel 0.5
beta_fCa 60.0
CQ_tot 10.0
K1no 1628.0
K_up 0.0006
kb_CM 0.542
Cao 2.0
Mgi 2.5
K2no 561.4
tau_dif_Ca 0.04
Qn 0.4315
g_st 0.015
kb_TMM 0.751
K3no 4.663
g_b_Na 0.0054
V_i 1.5835e-12
K2ni 2.289
kf_TMC 227.7
E_CaL 45.0
kb_CQ 0.445
P_up 0.005
Nao 140.0
Qci 0.1369
Kci 0.0207
E_st 37.4
V_sub 3.5098e-14
kb_TMC 0.00751
V_up 4.0816e-14
kNaCa 125.0
g_CaT 0.458
CM_tot 0.045
g_CaL 0.58
R 8.3144e15
F 9.6485e16
E_CaT 45.0

States:

Name Description
qa(time) 0.426018100136
paF(time) 0.3493633709533
piy(time) 0.852396631172
f(time) 0.626999773853
y(time) 0.067156687129
fCQ(time) 0.260317260703
fTC(time) 0.059206293446
n(time) 0.054409723782
fCMs(time) 0.074631965653
Ca_sub(time) 0.00019074741
fTMC(time) 0.602955114871
Nai(time) 9.438646305915
q(time) 0.531446952485
d(time) 0.000602055134
Ca_rel(time) 0.296742023718
fTMM(time) 0.350600895635
V(time) -58.600291137693
fCa(time) 0.589580408056
Ki(time) 139.984146485614
fCMi(time) 0.116947220413
r(time) 0.005550489445
qi(time) 0.333330378068
Ca_up(time) 1.462338380106
Cai(time) 0.000312494921
paS(time) 0.629323128348

Observables: none

kyrylov_severyanova_vieira_2005 @ v0.0.1

Kyrylov, Severyanova, Vieira, 2005

nothing

Parameters:

Name Description
a21 0.031
a22 -0.0957
a42 0.000139
a12 -0.0668
S4 0.01
a33 -0.00857
a44 -0.000143
a00 -0.00843
S1 0.01
S3 0.01
S2 0.01
e2 0.0
a11 -0.004
a10 0.082
e0 0.0
a23 0.0576
S0 0.01
epsilon 0.5
a02 -0.44
c0 0.443
a20 0.0
a24 0.000325
e1 0.0
a32 0.00869

States:

Name Description
y2(time) 1.17
y3(time) 0.95
y1(time) 1.4
y4(time) 0.65
y0(time) 0.4

Observables: none

L


lambeth_kushmerick_2002 @ v0.0.1

Lambeth, Kushmerick, 2002

nothing

Parameters:

Name Description
Keq_GAPDH 0.089
K_F6P 0.18
V_max_f 12000.0
var_e 0.01
Keq_PGK 57109.0
Keq_CK 233.0
K_G6P 0.18
Keq_ALD 9.5e-5
K_ATP_ 0.25
Keq_ENOL 0.49
K_G1P 1.5
K_AMP 1.9e-6
K_FBP 4.02
d 0.01
K_PEP 0.08
Ki_GLY_b 4.4
Keq_PGLM 16.62
Ki_ADP 0.135
Ki_Pi 4.6
K_PYR 7.05
K_F6P_ 20.0
Keq_PK 10304.0
K_three_PG 0.2
Keq_PGI 0.45
Keq_PGM 0.18
K_GLY_f 1.7
frac_a 0.4
K_FBP_ 4.02
nH 1.75
Keq_TPI 0.052
Ki_GLY_f 15.0
K_GAP 0.32
K_PCr 1.11
K_ADP 0.3
Lo 13.0
K_ADP_ 2.7
Keq_ADK 2.21
K_NADH 0.0033
Ka_AMP 0.06
K_GLY_b 0.15
K_Pi 0.2
frac_b 0.6
K_NAD 0.09
K_two_PG 0.014
V_ATPase 600.0
Ki_PCr 3.9
K_DHAP 0.61
K_Cr 3.8
Ki_G1P 7.4
V_max_r 880.0
K_LAC 17.0
Keq_LDH 16198.0
K_Thirteen_BPG 0.0008
K_ATP 1.13
Ki_ATP 0.87
Keq_GP 0.42

States:

Name Description
PEP(time) 0.0194
G6P(time) 0.75
Pi(time) 4.1
PCr(time) 34.67
Cr(time) 35.0
AMP(time) 0.99
PYR(time) 0.0994
two_PG(time) 0.005
ATP(time) 8.2
GAP(time) 0.0355
F6P(time) 0.228
Thirteen_BPG(time) 0.065
NAD(time) 0.5
LAC(time) 1.3
DHAP(time) 0.0764
FBP(time) 0.0723
GLY(time) 112.0
G1P(time) 0.0589
three_PG(time) 0.052
ADP(time) 0.013
NADH(time) 0.001

Observables: none

Land_et_al_2012 @ v0.0.1

Land et al. 2012

Land et al 2012

Parameters:

Name Description
T_ref 120.0
k_xb 0.1
Ca_50ref 0.8
perm50 0.35
n_TRPN 2.0
nperm 5.0
alpha_1 0.1
A_1 -29.0
a 0.35
beta_1 -1.5
alpha_2 0.5
k_off 0.1
A_2 116.0
beta_0 1.65

States:

Name Description
xb(time) 0.00046
Q_2(time) 0.0
TRPN(time) 0.0752
Q_1(time) 0.0

Observables: none

landesberg_sideman_1994 @ v0.0.1

Landesberg, Sideman, 1994

nothing

Parameters:

Name Description
f nothing
TRo nothing
L_b nothing
F_bar nothing
k_minus_h nothing
K_mu nothing
Ca_r nothing
d_alpha_dt nothing
B nothing
Q_u nothing
g_0 nothing
Troponin nothing
I_l nothing
SL nothing
Ca_0 nothing
L_a nothing
Q_i nothing
T_s nothing
tau_iR nothing
k_h nothing
Q_o nothing
tau_iF nothing
alpha nothing
U_s nothing
eta_PE nothing
Sp_0 nothing
D nothing
g_1 nothing
eta nothing
E nothing
Q_s nothing
L_z nothing
tau_SR nothing
tau_SF nothing
K_max nothing
L_prime_m nothing
k_1 nothing

States:

Name Description
U_s(time) nothing
Ubar_d(time) nothing
Tbar_s(time) nothing
A_n(time) nothing
Tbar_d(time) nothing
Ubar_s(time) nothing
Abar_d(time) nothing
Rbar_s(time) nothing
Abar_s(time) nothing
Ca(time) nothing
Rbar_d(time) nothing
T_s(time) nothing
R_s(time) nothing
A_s(time) nothing
BCa_h(time) nothing

Observables: none

larsen_olsen_kummer_2003 @ v0.0.1

On the encoding and decoding of calcium signals in hepatocytes

Many different agonists use calcium as a second messenger. Despite intensive research in intracellular calcium signalling it is an unsolved riddle how the different types of information represented by the different agonists, is encoded using the universal carrier calcium. It is also still not clear how the information encoded is decoded again into the intracellular specific information at the site of enzymes and genes. After the discovery of calcium oscillations, one likely mechanism is that information is encoded in the frequency, amplitude and waveform of the oscillations. This hypothesis has received some experimental support. However, the mechanism of decoding of oscillatory signals is still not known. Here, we study a mechanistic model of calcium oscillations, which is able to reproduce both spiking and bursting calcium oscillations. We use the model to study the decoding of calcium signals on the basis of co-operativity of calcium binding to various proteins. We show that this co-operativity offers a simple way to decode different calcium dynamics into different enzyme activities.

Parameters:

Name Description
K19 3.5
k20 0.81
k14 153.0
K_M 0.62
k18 79.0
k10 0.7
K11 3.0
k13 13.4
K15 0.16
k_rem 3.0
p 4.0
k8 32.24
K21 4.5
K17 0.05
K9 29.09
k12 2.8
k16 7.0
k_enz 3.0
k1 0.01
K4 0.09
k_inact 0.04
k_act 5.0
k3 0.64
k7 2.08
k5 4.88
k2 1.75
K6 1.18

States:

Name Description
PLC(time) 0.01
Ca_ER(time) 10.0
Enz(time) 0.0
Ca_cyt(time) 0.01
Pro(time) 0.0
Ca_mit(time) 0.001
G_a(time) 0.01

Observables: none

lebeau_robson_mckinnon_donald_sneyd_1997 @ v0.0.1

Lebeau, Robson, Mckinnon, Donald, Sneyd, 1997

nothing

Parameters:

Name Description
i_CaT nothing
f nothing
Cai nothing
T nothing
vp nothing
g_K_Ca nothing
tau nothing
Cae nothing
Ki nothing
i_K_Ca nothing
Cm nothing
tau_h nothing
tau_n nothing
E_L nothing
alpha nothing
Ke nothing
Kp nothing
KC nothing
g_L nothing
beta nothing
g_CaT nothing
g_K_DR nothing
i_K_DR nothing
g_CaL nothing
Ca_eq nothing
tau_m_ nothing
R nothing
i_Leak nothing
F nothing

States:

Name Description
V(time) nothing
n(time) nothing
m(time) nothing
h(time) nothing

Observables: none

lebeau_yule_groblewski_sneyd_1999 @ v0.0.1

Lebeau, Yule, Groblewski, Sneyd, 1999

nothing

Parameters:

Name Description
k2 0.5
alpha_1 40.0
beta_4 0.01
K_p 0.54
k_flux 28.0
alpha_4 0.06
beta_1 0.8
k3 0.5
V_p 2.6
k5 0.02
J_influx 0.4
k1_ 0.88
p 3.0

States:

Name Description
O(time) nothing
I2(time) nothing
c(time) nothing
I1(time) nothing

Observables: none

leloup_goldbeter_1998 @ v0.0.1

Leloup, Goldbeter, 1998

A Model for Circadian Rhythms in Drosophila Incorporating the Formation of a Complex between the PER and TIM proteins

Parameters:

Name Description
n 4.0
V_3 8.0
k_1 1.2
V_4P 1.0
K_1T 2.0
T_1init 0.8
K_mT 0.2
K_3 2.0
K_3T 2.0
v_sT 1.0
K_IT 1.0
Y_1init 0.8
V_1 8.0
k_2 0.2
V_4T 1.0
v_dT 2.0
K_2 2.0
V_4 1.0
k_d 0.01
V_2 1.0
v_d 2.0
M_Tinit 1.427
V_1P 8.0
k_3 1.2
v_mT 0.7
k_sP 0.9
P_2init 0.01251
K_1 2.0
K_4P 2.0
V_2T 1.0
K_1P 2.0
k_sT 0.9
V_3T 8.0
k_dN 0.01
Y_0init 0.02324
M_Pinit 0.09107
T_2init 4.733
Y_2init 4.733
k_4 0.6
k_s 0.9
K_d 0.2
K_dP 0.2
T_0init 0.542
K_2T 2.0
K_4 2.0
v_dT_dark 2.0
K_mP 0.2
K_m 0.2
V_1T 8.0
V_2P 1.0
P_1init 0.0221
K_I 1.0
P_0init 0.02324
v_s 0.8
K_dT 0.2
v_dP 2.0
v_dT_light 4.0
k_dC 0.01
PI 3.141592653589793
K_4T 2.0
V_3P 8.0
K_3P 2.0
K_2P 2.0
M_init 0.09107
v_sP 0.8
v_m 0.8
K_IP 1.0
v_mP 0.8

States:

Name Description
C_N(time) 1.203
P_0(time) 0.02324
P_2(time) 0.01251
T_1(time) 0.8
M(time) 0.09107
Y_0(time) 0.02324
C(time) 0.179
T_0(time) 0.542
Y_2(time) 4.733
Y_1(time) 0.8
T_2(time) 4.733
P_1(time) 0.0221
M_T(time) 1.427
M_P(time) 0.09107

Observables: none

leloup_goldbeter_2003 @ v0.0.1

Leloup, Goldbeter, 2003

nothing

Parameters:

Name Description
KmB 0.4
PCNP_init 0.1
Km 0.4
MR_init 1.5
V1 1.4
kdmr 0.02
V2PC 0.2
kdnc 0.02
IN_init 0.1
CC_init 0.1
MC_init 1.2
ke 0.2
ksC 3.2
vdPCN 1.4
k3 0.8
BC_init 0.1
vdRC 4.4
V3PC 2.4
vdCC 1.4
ka 0.4
vmB 1.3
KmP 0.3
PCP_init 0.1
vsP 2.4
MP_init 0.1
Kd 0.3
k6 0.4
ks 1.2
vdPCC 1.4
V2C 0.2
V4B 0.4
kdmb 0.02
V1P 9.6
Y_init 0.1
vmR 1.6
ksB 0.32
m 2.0
vm 2.0
M_init 1.2
MB_init 9.0
k2 0.4
n 2.0
vdBC 3.0
PCN_init 0.1
ksR 1.7
c 2.0
k9 0.8
vdIN 1.6
k8 0.2
V2P 0.6
V3B 1.4
V4PC 0.2
B 0.6
vdRN 0.8
vmP 2.2
V1C 1.2
KmC 0.4
KAP 0.6
YCP_init 0.1
kc 1.0
V1B 1.4
kdn 0.02
KAC 0.6
vmC 2.0
V1PC 2.4
kd 0.02
BCP_init 0.1
KAR 0.6
vsC 2.2
KmR 0.4
vsB 1.8
YC_init 0.1
PC_init 0.1
k10 0.4
kdmp 0.02
one 1.0
ksP 1.2
h 2.0
V2B 0.2
kdm 0.02
kdmc 0.02
Kdp 0.1
k4 0.4
V2 0.2
kb 0.8
vdPC 3.4
vs 2.2
A 2.2
PCCP_init 0.1
BN_init 0.1
Kp 1.006
PCC_init 0.1
vd 3.0
k1 0.8
BNP_init 0.1
vsR 1.6
CCP_init 0.1
KIB 2.2
k7 1.0
RN_init 0.1
vdBN 3.0
k5 0.8

States:

Name Description
IN(time) 0.1
PCNP(time) 0.1
PCCP(time) 0.1
YC(time) 0.1
PCN(time) 0.1
PCC(time) 0.1
MB(time) 9.0
MC(time) 1.2
BC(time) 0.1
BN(time) 0.1
PC(time) 0.1
MR(time) 1.5
M(time) 1.2
BCP(time) 0.1
CCP(time) 0.1
MP(time) 0.1
RC(time) 0.1
RN(time) 0.1
CC(time) 0.1
PCP(time) 0.1
YCP(time) 0.1
Y(time) 0.1
BNP(time) 0.1

Observables: none

leloup_goldbeter_2004 @ v0.0.1

Leloup, Goldbeter, 2004

nothing

Parameters:

Name Description
vdBC 1.0
PCN_init 0.1
c 4.0
vdIN 0.8
KmB 0.4
PCNP_init 0.1
Km 0.4
k8 0.1
V2PC 0.1
V1 1.0
V2P 0.3
V3B 1.0
kdnc 0.01
IN_init 0.1
V4PC 0.1
vstot 1.0
vmP 1.1
B 1.0
V1C 0.6
CC_init 0.1
KmC 0.4
KAP 0.7
YCP_init 0.1
MC_init 0.3
kc 0.5
V1B 1.0
kdn 0.01
KAC 1.0
ke 0.1
vdPCN 1.0
vmC 1.0
kd 0.01
BCP_init 0.1
k3 0.8
BC_init 0.1
kstot 1.0
YC_init 0.1
vdCC 0.7
ka 0.2
Vphos 0.6
vmB 0.2
PC_init 0.1
KmP 0.3
PCP_init 0.1
kdmp 0.01
V2B 0.1
kdm 0.01
kdmc 0.01
Kdp 0.3
k4 0.2
V2 0.1
kb 0.8
MP_init 0.5
Kd 0.3
k6 0.2
vdPC 0.7
vdPCC 1.0
V2C 0.1
V4B 0.2
A 0.8
PCCP_init 0.1
BN_init 0.1
Kp 0.1
PCC_init 0.1
vd 1.0
k1 0.8
kdmb 0.01
BNP_init 0.1
Y_init 0.1
m 4.0
CCP_init 0.1
KIB 0.8
vm 1.0
MB_init 3.1
M_init 0.3
k7 0.5
vdBN 0.5
k5 0.4
k2 0.2
n 4.0

States:

Name Description
IN(time) 0.1
BC(time) 0.1
PCNP(time) 0.1
M(time) 0.3
PCCP(time) 0.1
PC(time) 0.1
BN(time) 0.1
YC(time) 0.1
BCP(time) 0.1
YCP(time) 0.1
CCP(time) 0.1
MP(time) 0.5
PCN(time) 0.1
CC(time) 0.1
PCP(time) 0.1
PCC(time) 0.1
Y(time) 0.1
MB(time) 3.1
MC(time) 0.3
BNP(time) 0.1

Observables: none

leloup_gonze_goldbeter_1999 @ v0.0.1

Leloup, Gonze, Goldbeter, 1999

nothing

Parameters:

Name Description
KIT 1.0
ksT 0.9
T1_init 0.1
V3 8.0
K4T 1.0
P2_init 0.1
K3 2.0
V3P 8.0
Km 0.5
V1 8.0
K3T 2.0
V2P 1.0
KIP 1.0
K2T 2.0
KmT 0.2
T2_init 0.1
vmP 0.7
V2T 1.0
V4P 1.0
vdT 2.0
vdP 2.0
K2P 2.0
Y1_init 0.1
kd 0.01
K4 1.0
P0_init 0.1
T0_init 0.1
MT_init 1.6
V1T 8.0
k3 1.2
K3P 2.0
V4T 1.0
K1 2.0
K2 2.0
KmP 0.2
V3T 8.0
vsT 1.0
ksP 0.9
Y2_init 0.1
k4 0.6
vsP 1.0
V2 1.0
MP_init 0.1
kdN 0.01
Kd 0.13
KI 1.0
vmT 0.7
KdT 0.2
ks 0.5
vs 1.6
Y0_init 0.1
K4P 1.0
V4 1.0
vd 1.4
KdP 0.2
k1 0.5
V1P 8.0
P1_init 0.1
K1P 2.0
vm 0.505
M_init 0.1
kdC 0.01
K1T 2.0
k2 0.6
n 4.0

States:

Name Description
T1(time) 0.1
P0(time) 0.1
FC(time) 0.1
M(time) 0.1
C(time) 0.1
P1(time) 0.1
T2(time) 0.1
MT(time) 1.6
MP(time) 0.1
FN(time) 0.1
Y1(time) 0.1
P2(time) 0.1
T0(time) 0.1
CN(time) 1.25
Y2(time) 0.1
Y0(time) 0.1

Observables: none

lemaire_tobin_greller_cho_suva_2004 @ v0.0.1

Lemaire, Tobin, Greller, Cho, Suva, 2004

nothing

Parameters:

Name Description
Io 0.0
DC 0.0021
ko 0.35
f0 0.05
KOP 200000.0
SP 250.0
kB 0.189
dB 0.7
k4 0.017
DA 0.7
k6 3.0
DR 0.0007
IP 0.0
k1 0.01
KLP 3.0e6
kP 86.0
C_s 0.005
k3 0.00058
rL 1000.0
K 10.0
k5 0.02
k2 10.0
IL 0.0

States:

Name Description
R(time) 0.0
C(time) 0.0
B(time) 0.0

Observables: none

lemon_gibson_bennett_2003 @ v0.0.1

Lemon, Gibson, Bennett, 2003

nothing

Parameters:

Name Description
eta_2 5.2
K_c 0.4
epsilon_r 0.185
N_a 6.02252e17
L 1000.0
a_2 0.2
delta 0.001238
C_T 67.0
K_e 10.0
B_ER 120000.0
B_x 50.0
r_r 10.0
G_T 100000.0
eta_3 45.0
xi 0.85
K_2 100.0
d_2 1.05
v 5.0e-13
K_x 0.2
k_d 0.15
B_e 150.0
alpha 2.781e-5
k_deg 1.25
k_a 0.017
d_3 0.943
d_5 0.0823
k_3 0.4
eta_1 575.0
PIP_2_T 5.0e7
d_1 0.13
R_T 20000.0
K_1 5.0
k_e 0.006
K_ER 1200.0
k_r 0.000175
k_p 0.03

States:

Name Description
PIP_2(time) 4.9997e7
G(time) 0.0
h(time) 0.6155
RS_p(time) 0.0
IP_3(time) 0.01
RS(time) 17000.0
C(time) 0.0961

Observables: none

lenbury_pacheenburawana_1991 @ v0.0.1

Lenbury, Pacheenburawana, 1991

nothing

Parameters:

Name Description
omega 2.0
alpha 0.5
b 1.091
gamma 0.6
D 0.8228
a 8.1252
beta 0.38

States:

Name Description
x(time) 1.5
y(time) 0.95
z(time) 1.0

Observables: none

lenbury_pornsawad_2005 @ v0.0.1

Lenbury, Pornsawad, 2005

nothing

Parameters:

Name Description
delta1 0.5
delta2 0.38
delta3 0.6
beta 1.091

States:

Name Description
x(time) 1.0
y(time) 0.01
z(time) 0.01

Observables: none

lenbury_ruktamatakul_amornsamarnkul_2001 @ v0.0.1

Lenbury, Ruktamatakul, Amornsamarnkul, 2001

nothing

Parameters:

Name Description
c1 0.1
r5 0.09
r_2 0.1
delta 0.01
r_4 0.1
r4 0.03
r_6 0.1
omega 0.05
c_1 0.1
r_7 0.05
y_hat 1.24
y_ 1.08
c_2 0.1
r3 0.05
c2 0.1
r_5 0.1
r_1 0.2
r_3 0.1
z_ 1.01
r7 0.05
r1 0.15
r2 0.12
z_hat 2.0
epsilon 0.1
c3 0.005
r6 0.1

States:

Name Description
u(time) 1.0
v(time) 0.0
x(time) 5.0
y(time) 0.0
z(time) 1.0

Observables: none

li_bertram_rinzel_1996 @ v0.0.1

Li, Bertram and Rinzel, 1996

nothing

Parameters:

Name Description
C_m 1.0
k_Ca 1.0
V_h -30.0
g_K_Ca 1.2
K_p 15.0
R_pump 18.0
V_K -85.0
g_K_DR_D 0.14
g_h 0.1
K_Ca 0.0004
V_NMDA 0.0
V_Na 55.0
g_K_DR_s 6.4
q 12.5
g_Na_s 3.2
alpha 0.5
K_Mg 10.0
g_Na 3.2
K_Na 15.0
g_L 0.18
V_L -50.0
beta 0.104
I_APP -6.7
Na_eq 8.0
g_NMDA 1.25
V_Ca 120.0
Mg_o 1.4
g_Ca_T 1.5
g_Ca_L 0.19
g_K_DR 3.2
g_Na_NMDA 1.0
g_c 0.0
g_A 2.0
p 0.5

States:

Name Description
h(time) 1.0
a(time) 0.1
V_s(time) -64.0
Na(time) 5.09
m_L(time) 0.1
h_T(time) 0.1
Ca(time) 0.0
b(time) 0.1
m_h(time) 0.1
n(time) 0.002
V_D(time) -25.0
m_T(time) 0.1

Observables: none

li_kuang_mason_2006 @ v0.0.1

Li, Kuang, Mason, 2006

nothing

Parameters:

Name Description
C3 1000.0
Rm 210.0
Gin 0.54
a1 300.0
Ub 72.0
alpha 0.29
C4 80.0
di 0.06
E 0.2
Um 940.0
beta 1.77
C1 2000.0
C2 144.0
ti 100.0
U0 40.0
Vp 3.0
C5 26.0
Vg 10.0
Rg 180.0
Vi 11.0

States:

Name Description
G(time) 1000.0
I(time) 9000.0

Observables: none

li_rinzel_1994 @ v0.0.1

Li, Rinzel, 1994

nothing

Parameters:

Name Description
c1 0.185
v4 1.8
v1 40.0
d_inh 0.4
k_er 0.18
a 1.0
d_act 0.4
IP3 0.6
k_pl 0.1
d_ip3 0.2
epsilon 0.01

States:

Name Description
j_in(time) 1.2
h(time) 0.8
v3(time) 0.6
C(time) 0.2
v2(time) 0.02
c0(time) 2.0

Observables: none

li_smith_2009 @ v0.0.1

Li, Smith, 2009

nothing

Parameters:

Name Description
const5 6.6755
T 308.0
Km_CSQN 800.0
delta_V_L 7.0671
stim_offset 100.0
P_ryr_const1 -0.09
Km_Nai 21000.0
k_plus_a 0.006075
kf 0.023761
Bmax 109.0
Km_Cl 10.0
Ko 5400.0
i_NaK_max 1.66
on_rate 0.05
Cm 1.0
K_L 0.0964
vmup_init 0.3158
E_Cl -40.0
g_Kto_f 0.4067
k_sat 0.1
K_mNa 86500.0
eta 0.35
V_L -2.0
g_Ks 0.00575
g_K1 0.2938
i_CaL_max 4.0
tau_tr 20.0
g_Kr 0.078
Acap 0.00013866
K_mCa 1380.0
Km_pCa 0.4
P_ryr_const2 -0.225
k_minus_a 0.07125
P_CaL 19.1078
stim_duration 3.0
k_minus_b 0.965
v1 4.5
i_pCa_max 0.9
Cao 1400.0
b 14.0
Vmyo 2.2e-5
g_Nab 0.0026
tau_xfer 8.0
Km_up 0.412
g_Kto_s 0.0
a 0.07
Km_Ko 1500.0
stim_period 333.3333333
kb 0.036778
Kd 0.6
k_plus_b 0.00405
CSQN_tot 15000.0
off_rate 0.00068
Nao 134000.0
g_Na 13.0
VJSR 1.022e-7
k_plus_c 0.009
g_Cab 0.00088
stim_amplitude -15.0
tau_L 972.9715
g_ClCa 10.0
VNSR 1.786e-6
m 3.0
phi_L 1.6411
g_Kss 0.05
v2 1.0e-5
k_minus_c 0.0008
Vss 1.264e-9
g_Kur 0.16
k_NaCa 772.8991
R 8.314
t_L 1.1683
F 96.5
n 4.0

States:

Name Description
C_Na2(time) 0.01702105
O_K(time) 0.0004858865
I(time) 0.009171979
O_Na(time) 2.639399e-7
ato_f(time) 0.001937245
P_C2(time) 0.3797679
I2_Na(time) 5.460299e-6
C_K2(time) 0.0005301217
O(time) 4.373318e-6
IC_Na2(time) 0.005985434
C_Na1(time) 0.0001581035
P_RyR(time) 2.290355e-9
ito_f(time) 0.9999985
nKs(time) 0.002206261
I1_Na(time) 1.799179e-5
Nai(time) 16522.45
Cass(time) 0.1043777
y_gate(time) 0.8876797
IC_Na3(time) 0.2543133
ato_s(time) 0.02000568
V(time) -85.64004
IF_Na(time) 5.56206e-5
CaJSR(time) 730.0589
C_K1(time) 0.0007799137
CaMKt(time) 0.08989079
aur(time) 0.02000568
iur(time) 0.9822006
iKss(time) 1.0
P_O1(time) 0.003825599
Ki(time) 141474.0
I_K(time) 7.519518e-5
CaNSR(time) 841.106
ito_s(time) 0.9308568
Cai(time) 0.1040595
P_O2(time) 1.835831e-8
aKss(time) 0.8883113

Observables: none

lindblad_murphey_clark_giles_1996 @ v0.0.1

Lindblad, Murphey, Clark, Giles, 1996

nothing

Parameters:

Name Description
KmK1 0.59
T 308.0
stim_start 0.1
P_Na 1.4e-6
Mg_i 2.5
d_NaCa 0.0003
alpha_rel 200.0
k_NaK_K 1.0
i_NaK_max 0.06441
I_up_max 2.8
g_to 0.050002
g_B_Cl 0.00012
k_CaP 0.0002
Cm 5.0e-5
shiftK1 -3.6
Ca_c 2.5
Vol_rel 4.41e-8
Vol_i 1.26e-5
k_rel 0.0003
Cl_c 132.0
Vol_up 3.969e-7
g_Ks 0.0025
g_K1 0.005088
k_xcs 0.4
tau_tr 0.01
g_Kr 0.0035
g_Ca_L 0.004
steepK1 1.393
stim_duration 0.0008
K_c 5.0
Na_c 140.0
g_B_Na 6.4e-5
E_Ca_T 38.0
stim_period 1.0
stim_end 100000.0
k_NaK_Na 11.0
k_srca 0.5
Cl_i 30.0
i_CaP_max 0.009509
g_B_Ca 3.1e-5
stim_amplitude -2.0
k_cyca 0.0003
Vol_Ca 5.884e-6
E_Ca_app 60.0
g_Ca_T 0.006
gamma 0.45
k_NaCa 2.0e-5
k_F3 0.815
R 8314.472
F 96485.3415

States:

Name Description
O_TC(time) 0.01442
F3(time) 0.68492
s2(time) 0.39871
O_Calse(time) 0.41837
f_T(time) 0.30752
s3(time) 0.57363
d_L(time) 3.0e-5
s1(time) 0.5753
m(time) 0.01309
Na_i(time) 8.4
O_C(time) 0.02981
d_T(time) 0.00046
Ca_rel(time) 0.59984
h2(time) 0.61493
O_TMgMg(time) 0.67476
V(time) -69.83663
p_i(time) 0.76898
p_a(time) 0.00016
z(time) 0.02032
K_i(time) 100.0
r(time) 6.0e-5
F1(time) 0.21603
f_L(time) 0.99981
h1(time) 0.706
Ca_up(time) 0.64913
Ca_i(time) 7.305e-5
F2(time) 0.00205
O_TMgC(time) 0.23532

Observables: none

liu_hu_peng_liu_1999 @ v0.0.1

Liu, Hu, Peng, Liu, 1999

nothing

Parameters:

Name Description
a21 200.0
a13 460.0
a2 0.0023
a1 1.7e-5
lambda_1 0.059
a15 0.1
a22 9400.0
a18 3800.0
a7 0.28
a12 18.0
lambda_3 0.0986
a5 36.0
a19 57.0
a27 0.57
a3 0.6
lambda_5 3.0e-5
lambda_4 0.024
a14 0.46
a4 45.0
a6 216.0
lambda_2 0.028
a10 0.18
a8 0.36
a11 150.0
a17 150.0
a23 10.0
a25 0.04
a26 0.00097
a16 0.04
a9 0.0003
a20 2600.0
a28 0.0017
a24 320.0

States:

Name Description
x4(time) 60.61
x3(time) 6.51
x5(time) 12.61
x2(time) 0.04665
x1(time) 0.01067

Observables: none

livervolume @ v0.0.1

Volume mesh of liver

nothing

Parameters: none

States: none

Observables: none

livshitz_rudy_2007 @ v0.0.1

Livshitz, Rudy, 2007

nothing

Parameters:

Name Description
prnak 0.01833
GNa 16.0
qn 9.0
gcab 0.003016
ganai 0.75
GKsmax 0.433
iupbar 0.00875
tau 4.75
Temp 310.0
pk 1.93e-7
stim_offset 0.0
kmup 0.00092
ibarpca 1.15
tautr 120.0
kmko 1.5
GKpmax 0.00552
kmpca 0.0005
c2 0.0001
K_Relss 1.0
l 0.01
trpnbar 0.07
gako 0.75
kmtrpn 0.0005
c1 0.00025
Na_o 140.0
nsrbar 15.0
stim_duration 3.0
ibarnak 2.25
csqnbar 10.0
Ca_o 1.8
stim_period 400.0
kmcmdn 0.00238
pna 6.75e-7
kappa 0.125
gacai 1.0
K_o 4.5
ganao 0.75
gacao 0.341
ra 0.0011
GNab 0.004
kmnai 10.0
GK1max 0.75
gcat 0.05
kmca 0.0006
kmcsqn 0.8
pca 0.00054
stim_amplitude -15.0
gammas 0.15
gaki 0.75
R 8314.0
cmdnbar 0.05
F 96485.0
gkrmax 0.02614

States:

Name Description
d(time) 3.2514786721066e-27
g(time) 0.952834331760863
xr(time) 0.000162194715543637
Ca_JSR_T(time) 7.87371650296567
Ca_NSR(time) 2.71518235696672
V(time) -89.4356034692784
f(time) 0.997404948824816
K_i(time) 139.730914103161
J(time) 0.996100688673679
Rel(time) 1.06874246141923e-23
Over(time) 1.0e-12
xs1(time) 0.0285147332973946
b(time) 0.000927461915392873
H(time) 0.994401369032678
Ca_T(time) 0.0257059808595638
m(time) 0.000734780346592185
xs2(time) 0.0764114040188678
Na_i(time) 16.612739313555

Observables: none

lockwood_ewy_hermann_holford_2006 @ v0.0.1

Lockwood, Ewy, Hermann, Holford, 2006

Application of Clinical Trial Simulation to Compare Proof-of-Concept Study Designs for Drugs with a Slow Onset of Effect; An Example in Alzheimer’s Disease

Parameters:

Name Description
t_half_eq_p 6.0
t_half_el_p 7.0
alpha 0.0164
beta_a -0.047
k_ab 115.44
CL_ic 763.2
age 40.0
S0 30.0
epsilon 0.0
beta_P -3.0
Vp 222.0
CeA 25.0
smk 1.0
Vc 172.0

States:

Name Description
CC(time) 0.0
PC(time) 0.0
A_in(time) 25.0

Observables: none

lokta_volterra @ v0.0.1

Lokta, Volterra

Predator-prey equations

Parameters:

Name Description
B 1.0
A 1.0
C 1.0
D 1.0

States:

Name Description
x(t) 3.0
y(t) 6.0

Observables: none

Lorenz_1963 @ v0.0.1

Deterministic Nonperiodic Flow

The Lorenz attractor, named for Edward N. Lorenz, is an example of a non-linear dynamic system corresponding to the long-term behavior of the Lorenz oscillator. The Lorenz oscillator is a 3-dimensional dynamical system that exhibits chaotic flow, noted for its lemniscate shape. The map shows how the state of a dynamical system (the three variables of a three-dimensional system) evolves over time in a complex, non-repeating pattern.

From http://en.wikipedia.org/wiki/Lorenz_attractor

Parameters: none

States:

Name Description
z(t) 1.05
x(t) 0.0
y(t) 1.0

Observables: none

lovell_cloherty_celler_dokos_2004 @ v0.0.1

Lovell, Cloherty, Celler, Dokos, 2004

nothing

Parameters:

Name Description
K3ni nothing
PKNa_s nothing
beta1_Eslope nothing
T nothing
beta4_0 nothing
g_bCl nothing
alpha2_Eslope nothing
beta2_0 nothing
Iup_max nothing
beta1_0 nothing
alpha4_0 nothing
beta4_infinity nothing
Vup nothing
K1ni nothing
PKNa_r nothing
alpha3_infinity nothing
Ve nothing
Cab nothing
alpha3_Eslope nothing
g_f_K nothing
beta3_Eslope nothing
Kb nothing
beta3 nothing
P_f_K nothing
g_to nothing
Kcni nothing
Cm nothing
beta2_E50 nothing
beta4 nothing
Qco nothing
alpha3_E50 nothing
beta1_E50 nothing
beta4_Eslope nothing
alpha2_0 nothing
alpha1_infinity nothing
Kco nothing
g_Ks nothing
alpha2_infinity nothing
alpha4_Eslope nothing
alpha1_Eslope nothing
tau_b nothing
g_Kr nothing
Km_Caup nothing
tau_tr nothing
alpha4_E50 nothing
alpha1_E50 nothing
alpha3_0 nothing
Km_Na nothing
tau_rel nothing
beta3_E50 nothing
K1no nothing
Clb nothing
alpha1_0 nothing
beta3_infinity nothing
Km_f nothing
K2no nothing
Qn nothing
Nab nothing
Km_Carel nothing
beta2_infinity nothing
beta3_0 nothing
beta4_E50 nothing
K3no nothing
alpha3 nothing
K2ni nothing
Vi nothing
Qci nothing
Kci nothing
g_Na nothing
alpha4 nothing
alpha2_E50 nothing
g_f_Na nothing
beta2_Eslope nothing
kNaCa nothing
g_CaT nothing
Km_K nothing
Ip_max nothing
g_CaL nothing
alpha4_infinity nothing
beta1_infinity nothing
R nothing
Vrel nothing
F nothing
Kb_K nothing

States:

Name Description
Caup(time) nothing
A_Kr(time) nothing
Em(time) nothing
A_to(time) nothing
Cli(time) nothing
A_CaL(time) nothing
Cao(time) nothing
A_f(time) nothing
Clo(time) nothing
Ko(time) nothing
A_Ks(time) nothing
I2(time) nothing
Ki(time) nothing
A_CaT(time) nothing
I3(time) nothing
Cai(time) nothing
Nai(time) nothing
Carel(time) nothing
A_Na(time) nothing
I1(time) nothing
Nao(time) nothing

Observables: none

luo_rudy_1991 @ v0.0.1

Luo, Rudy, 1991

nothing

Parameters:

Name Description
g_b 0.03921
stim_duration 2.0
T 310.0
C 1.0
stim_start 100.0
Nao 140.0
g_Na 23.0
PR_NaK 0.01833
E_b -59.87
g_Kp 0.0183
Ki 145.0
stim_end 9000.0
stim_period 1000.0
Nai 18.0
stim_amplitude -25.5
Ko 5.4
R 8314.0
F 96484.6

States:

Name Description
d(time) 0.00302126301779861
j(time) 0.989108212766685
V(time) -84.3801107371
h(time) 0.982660523699656
X(time) 0.0417603108167287
m(time) 0.00171338077730188
Cai(time) 0.00017948816388306
f(time) 0.999967936476325

Observables: none

luo_rudy_1994 @ v0.0.1

Luo, Rudy, 1994

nothing

Parameters:

Name Description
gamma_Cai 1.0
gamma_Cao 0.34
T 310.0
P_Na 6.75e-9
Km_Ca 0.0006
delta_Ca_i2 0.0
K_mup 0.00092
G_rel_max 60.0
delta_Ca_ith 0.00018
K_sat 0.1
Ko 5.4
gamma_Nao 0.75
tau_on 2.0
Cm 0.01
stimCurrent 0.5
stimDuration 0.5
P_ns_Ca 1.75e-9
V_NSR 0.0552
Am 200.0
PR_NaK 0.01833
K_mNa 87.5
eta 0.35
V_myo 0.68
tau_tr 180.0
Ca_NSR_max 15.0
g_K_max 0.00282
K_mCa 1.38
g_K1_max 0.0075
Cao 1.8
g_Nab 1.41e-5
t_CICR 0.0
gamma_Nai 0.75
K_mpCa 0.0005
V_JSR 0.0048
gamma_Ki 0.75
K_m_ns_Ca 0.0012
tau_off 2.0
I_pCa 0.0115
I_NaK 0.015
Nao 140.0
K_mNai 10.0
P_Ca 5.4e-6
g_Na 0.16
stimPeriod 1000.0
I_up 0.005
g_Cab 3.016e-5
g_Kp 0.000183
K_mrel 0.0008
gamma_Ko 0.75
K_NaCa 20.0
K_mKo 1.5
R 8314.5
P_K 1.93e-9
F 96845.0

States:

Name Description
d(time) 0.0
V(time) -84.624
X(time) 0.0
Ca_NSR(time) 1.8
h(time) 1.0
f(time) 1.0
Ca_JSR(time) 1.8
Ki(time) 145.0
j(time) 1.0
m(time) 0.0
Cai(time) 0.00012
Nai(time) 10.0

Observables: none

M


macgregor_leng_2005 @ v0.0.1

Macgregor, Leng, 2005

nothing

Parameters:

Name Description
delta_r 0.2
c 0.01
Ise 10.0
theta_3 30.0
Is2 50.0
theta_1 1.0
n1 4.0
k8 0.07
theta_2 30.0
delta 60.0
sr -0.56
k4 0.5
sb 0.029
g2 0.008
k6 5.0
n3 5.0
g1 1.0
j1 10.0
gmax 5.0
k1 0.1
Ih 50.0
n2 2.0
delta1 15.0
k3 0.018
delta_b 0.3
k7 5.0
k5 71.0
k2 0.002

States:

Name Description
hh(time) 0.0
g(time) 2.0
r(time) 0.0
h(time) 0.0
s(time) 0.0
f(time) 0.3
se(time) 0.0

Observables: none

mackenzie_loo_panayotova_heiermann_wright_1996 @ v0.0.1

Mackenzie, Loo, Panayotova-Heiermann and Wright, 1996

nothing

Parameters: none

States: none

Observables: none

magnus_keizer_1997 @ v0.0.1

Magnus, Keizer, 1997

nothing

Parameters:

Name Description
pH_m nothing
na nothing
f nothing
rb nothing
Jmax_ant nothing
T nothing
Na_i nothing
Ca_i nothing
L nothing
pb nothing
K_Ca nothing
Jmax_uni nothing
pH_i nothing
ATP_m nothing
pa nothing
g nothing
Cmito nothing
g_H nothing
pc2 nothing
ATP_i nothing
r2 nothing
ADP_i nothing
pc1 nothing
rho_F1 nothing
p2 nothing
p1 nothing
rc2 nothing
p3 nothing
V_offset nothing
b nothing
fm nothing
K_trans nothing
ra nothing
rho_res nothing
r3 nothing
V_B nothing
NAD_m nothing
K_res nothing
Jmax_Na_Ca nothing
Pi_m nothing
K_Na nothing
NADH_m nothing
K_act nothing
r1 nothing
K_F1 nothing
rc1 nothing
R nothing
F nothing
n nothing

States:

Name Description
V(time) nothing
Ca_m(time) nothing
ADP_m(time) nothing

Observables: none

magnus_keizer_1998 @ v0.0.1

Magnus, Keizer, 1998

nothing

Parameters:

Name Description
K_tt nothing
na nothing
k_Ca nothing
C nothing
V_K nothing
K_Ca nothing
Jmax_ANT nothing
beta3 nothing
ATP_m nothing
beta6 nothing
K_dd nothing
g_H nothing
pc2 nothing
Jmax_NaCa nothing
k_minus_2 nothing
g_K_ATP nothing
K_td nothing
r2 nothing
glu nothing
Tmin nothing
rho_F1 nothing
p1 nothing
pc1 nothing
n_hyd nothing
ATP_m_free nothing
tau_hyd nothing
p3 nothing
b nothing
K_trans nothing
beta7 nothing
beta1 nothing
r3 nothing
k_hyd nothing
k_plus_2 nothing
alpha nothing
K_res nothing
gamma2 nothing
beta5 nothing
Jp_TCA nothing
f_i nothing
K_act nothing
r1 nothing
rc1 nothing
F nothing
n nothing
pH_m nothing
f nothing
T nothing
tau_Ca_f nothing
k_plus_3 nothing
delta_psi_offset nothing
L nothing
pb nothing
delta_J_gly_total nothing
beta2 nothing
tau_I nothing
Jmax_uni nothing
g_Ca nothing
J_red_basal nothing
K_Ca2 nothing
pH_i nothing
pa nothing
g nothing
beta4 nothing
Cmito nothing
beta_max nothing
u2 nothing
k_minus_3 nothing
rc2 nothing
p2 nothing
g_NS nothing
fm nothing
K_NS nothing
Ca_o nothing
TJ nothing
ra nothing
delta_J_hyd_max nothing
rho_res nothing
u1 nothing
K_Na nothing
Pi_m nothing
K_glu nothing
g_K_dr nothing
gamma1 nothing
K_F1 nothing
R nothing
rb nothing
Na_i nothing

States:

Name Description
NADH_m(time) nothing
V(time) nothing
I(time) nothing
Ca_m(time) nothing
C(time) nothing
B(time) nothing
J(time) nothing
delta_J_hyd(time) nothing
delta_psi(time) nothing
n(time) nothing
ADP_i(time) nothing
ADP_m(time) nothing
Ca_i(time) nothing

Observables: none

mahajan_shiferaw_sato_baher_olcese_xie_yang_chen_restrepo_karma_garfinkel_qu_weiss_2008 @ v0.0.1

Mahajan, Shiferaw, Sato, Baher, Olcese, Xie, Yang, Chen, Restrepo, Karma, Garfinkel, Qu, Weiss, 2008

nothing

Parameters:

Name Description
gca 182.0
T 308.0
cup 0.5
ay 0.05
kmem 0.3
stim_offset 0.0
xmcai 0.0036
s6 8.0
sx 3.0
av 11.3
wca 8.0
tca 78.0329
xmcao 1.3
taur 30.0
k2t 0.00224
vx -40.0
xmnao 87.5
vy -40.0
gtos 0.04
prNaK 0.01833
gNaK 1.5
bcal 24.0
xkon 0.0327
xkdna 0.3
r2 3.0
xkmko 1.5
xkmnai 12.0
vyr -40.0
ksar 13.0
gkr 0.0125
syr 11.32
gtof 0.11
Na_o 136.0
gleak 2.069e-5
vth 0.0
gks 0.1386
K_i 140.0
stim_duration 3.0
taups 0.5
Ca_o 1.8
gdyad 9000.0
taupo 1.0
gryr 2.58079
stim_period 400.0
k1t 0.00413
xkcal 7.0
ax 0.3576
s1t 0.00195
K_o 5.4
taud 4.0
srmax 47.0
xmnai 12.3
cstar 90.0
gna 12.0
gbarsr 26841.8
gkix 0.3
taua 100.0
cpt 6.09365
srkd 0.6
gNaCa 0.84
sy 4.0
kj 50.0
tau3 3.0
pca 0.00054
stim_amplitude -15.0
r1 0.3
cat 3.0
bsar 42.0
btrop 70.0
vup 0.4
bmem 15.0
R 8.314472
xkoff 0.0196
F 96.4853415
k2 0.000103615

States:

Name Description
trops(time) 19.864701949854
xi2ca(time) 0.004173008466
xi1ba(time) 3.3616596e-5
xr(time) 0.007074239331
Ca_NSR(time) 104.450004990523
xtof(time) 0.003643592594
xir(time) 0.006679257264
c2(time) 0.979322592773
xh(time) 0.990691306716
xs1(time) 0.048267587131
Ca_dyad(time) 1.716573130685
xs2(time) 0.105468807033
Na_i(time) 11.441712311614
V(time) -87.169816169406
Ca_submem(time) 0.226941113355
xj(time) 0.993888937283
c1(time) 1.8211252e-5
ytos(time) 0.174403618112
xtos(time) 0.00364776906
Ca_JSR(time) 97.505463697266
xm(time) 0.001075453357
ytof(time) 0.993331326442
xi1ca(time) 0.001208153482
xi2ba(time) 0.015242594688
tropi(time) 22.171689894953
Ca_i(time) 0.256752008084

Observables: none

maldonado_borchers_findeisen_allgower_2006 @ v0.0.1

Maldonado, Borchers, Findeisen and Allgower, 2006

nothing

Parameters:

Name Description
Io 0.0
SP 250.0
X_c 0.0009127
k_yd 1.0
K_l_p 3.0e6
D_A 0.7
k_nokl 100.0
k_nod 1000.0
k_res 0.01
k_y 1.0
Il 0.0
IP 0.0
X_bss 0.0007282
k_B 0.189
k_for 0.001
C_s 0.005
k3 0.00058
k_pger 0.0001
K 10.0
k_Fs 1.0
K_o_p 200000.0
f0 0.05
ko 0.35
X_y 0.0073
X_yss 0.0073
k_rB 1.0
X_b 0.0007282
k_nopg 10.0
dB 0.7
k4 0.017
k_byp 0.1
k6 3.0
k_opgd 0.35
k_yno 20000.0
D_C 0.189
D_R 0.0007
k1 0.01
k_nopge 1.0
k_pged 100.0
kP 86.0
X_noe 0.0
k_ypge 100.0
X_pgex 0.0
k5 0.02
rl 1000.0
k2 10.0

States:

Name Description
x_no(time) 0.02
xy(time) 0.0073
xc(time) 0.0009127
xr(time) 0.0007734
r_B(time) 0.9912
x_kl(time) 0.01
x_pge(time) 0.01
x_opg(time) 0.01
xb(time) 0.0007282

Observables: none

maleckar_greenstein_trayanova_giles_2009 @ v0.0.1

Maleckar, Greenstein, Trayanova, Giles, 2009

nothing

Parameters:

Name Description
gamma_Na 0.45
k_Ca 0.025
T 306.15
P_Na 0.0018
tau_K 10.0
Mg_i 2.5
stim_offset 0.0
d_NaCa 0.0003
tau_di 0.01
alpha_rel 200000.0
i_NaK_max 68.55
I_up_max 2800.0
phi_Na_en 0.0
k_CaP 0.0002
Cm 50.0
Ca_b 1.8
Vol_rel 4.41e-5
Vol_i 0.005884
g_kur 2.25
Na_b 130.0
Vol_up 0.0003969
g_Ks 1.0
g_K1 3.1
k_xcs 0.4
tau_tr 0.01
g_Kr 0.5
k_rel_i 0.0003
g_Ca_L 6.75
ACh 1.0e-24
pow_K_NaK_Na_15 36.4829
stim_duration 0.006
g_B_Na 0.060599
k_rel_d 0.003
stim_period 1.0
K_NaK_K 1.0
k_srca 0.5
g_t 8.25
tau_Ca 24.7
Vol_d 0.00011768
r_recov 0.815
i_CaP_max 4.0
Vol_c 0.000800224
g_B_Ca 0.078681
stim_amplitude -15.0
tau_Na 14.3
k_cyca 0.0003
E_Ca_app 60.0
K_NaCa 0.0374842
R 8314.0
F 96487.0
K_b 5.4

States:

Name Description
O_TC(time) 0.012922
O_Calse(time) 0.431547
O(time) 1.38222
n(time) 0.004374
d_L(time) 1.4e-5
m(time) 0.003289
f_L1(time) 0.998597
s(time) 0.948597
Na_i(time) 8.516766
O_C(time) 0.026766
pa(time) 5.3e-5
Ca_rel(time) 0.632613
h2(time) 0.873881
O_TMgMg(time) 0.714463
V(time) -74.031982
K_c(time) 5.560224
f_L2(time) 0.998586
Ca_c(time) 1.815768
K_i(time) 129.485991
Ca_d(time) 7.1e-5
r(time) 0.001089
F1(time) 0.470055
h1(time) 0.877202
Na_c(time) 130.022096
Ca_up(time) 0.649195
a_ur(time) 0.000367
Ca_i(time) 6.5e-5
F2(time) 0.002814
O_TMgC(time) 0.190369
i_ur(time) 0.96729

Observables: none

maltsev_2009 @ v0.0.1

Maltsev 2009

nothing

Parameters:

Name Description
K3ni 26.44
T 310.15
Km_fCa 0.00035
TC_tot 0.031
Km_Kp 1.4
kf_TC 88.8
Km_Nap 14.0
K1ni 395.3
EC50_SR 0.45
i_NaK_max 2.88
Ko 5.4
MaxSR 15.0
Kcni 26.44
Cm 32.0
L_sub 0.02
g_to 0.252
alpha_fCa 0.021
kb_TC 0.446
Qco 0.0
V_nsr_part 0.0116
kf_TMM 2.277
Kco 3.663
g_Ks 0.0259
kf_CM 227.7
TMC_tot 0.062
kim 0.005
V_i_part 0.46
g_Kr 0.08113973
kf_CQ 0.534
tau_tr 40.0
g_sus 0.02
g_b_Ca 0.0006
CQ_tot 10.0
K1no 1628.0
K_up 0.0006
kb_CM 0.542
Cao 2.0
g_if 0.15
Mgi 2.5
VIf_half -64.0
K2no 561.4
Ki 140.0
Qn 0.4315
g_st 0.003
tau_dif_Ca 0.04
kb_TMM 0.751
koCa 10.0
K3no 4.663
kom 0.06
g_b_Na 0.00486
K2ni 2.289
kf_TMC 227.7
MinSR 1.0
ks 250000.0
E_CaL 45.0
kb_CQ 0.445
P_up 0.012
Qci 0.1369
Nao 140.0
HSR 2.5
kiCa 0.5
E_st 37.4
Kci 0.0207
kb_TMC 0.00751
Nai 10.0
V_jsr_part 0.0012
kNaCa 187.5
L_cell 70.0
g_CaT 0.1832
R_cell 4.0
g_CaL 0.464
CM_tot 0.045
R 8314.4
F 96485.0
E_CaT 45.0

States:

Name Description
qa(time) 0.42380243163
paS(time) 0.453100576739
paF(time) 0.144755091176
dT(time) 0.00504393374639
I(time) 7.86181717518e-8
pi_(time) 0.849409822329
y(time) 0.113643187247
fT(time) 0.420757825415
fCQ(time) 0.273207128393
O(time) 1.7340201253e-7
Ca_nsr(time) 1.49348117734
fTC(time) 0.0291316176172
n(time) 0.0264600410928
fCMs(time) 0.054381370046
Ca_sub(time) 0.000138112560112
fTMC(time) 0.432694959597
q(time) 0.694241313965
Ca_jsr(time) 0.316762674605
RI(time) 0.311951987007
fTMM(time) 0.501049376634
fCa(time) 0.711395919653
fCMi(time) 0.0594880901438
r(time) 0.00558131733359
qi(time) 0.447294008304
Vm(time) -57.9639346865
R(time) 0.688047760973
dL(time) 0.000584545564405
Cai(time) 0.000150018670943
fL(time) 0.862381249774

Observables: none

maly_wiley_lauffenburger_2004 @ v0.0.1

Maly, Wiley, Lauffenburger, 2004

nothing

Parameters: none

States: none

Observables: none

margaridamartins_mendes_coreiro_pocesfreire_2001 @ v0.0.1

Margaridamartins, Mendes, Coreiro, Pocesfreire, 2001

nothing

Parameters:

Name Description
HTA 1.0
Kmq 0.49
V 0.0812
Kmp 0.61
Kms 0.61
Keq 0.61
D_lactate 0.0

States:

Name Description
SDLGSH(time) 1.0
GSH(time) 1.0

Observables: none

marhl_haberichter_brumen_heinrich_2000 @ v0.0.1

Marhl, Haberichter, Brumen, Heinrich, 2000

nothing

Parameters:

Name Description
k_m 0.00625
beta_ER 0.0025
k_plus 0.1
K1 5.0
K2 0.8
k_ch 4100.0
k_leak 0.05
Ca_tot 90.0
rho_m 0.01
k_in 300.0
k_minus 0.01
k_out 125.0
Pr_tot 120.0
beta_m 0.0025
rho_ER 0.01
K3 5.0
k_pump 20.0

States:

Name Description
Ca_cyt(time) 0.05
Ca_m(time) 0.4
Ca_ER(time) 1.0

Observables: none

marhl_schuster_brumen_heinrich_1997 @ v0.0.1

Marhl, Schuster, Brumen, Heinrich, 1997

nothing

Parameters:

Name Description
k_pump 76.0
T 310.0
k_leak 10.0
A_tot 3890.0
Ca_tot 45.0
C_tot 5000.0
Vcyt 5.84e-11
k_minus 0.5
rho 0.01
S 0.00616
Pr_tot 600.0
g_Ca_max 100.0
K_Ca 5.0
R 8.3143
F 96.4867
k_plus 0.1

States:

Name Description
Pr(time) nothing
Ca_cyt(time) nothing

Observables: none

martinov_vitvitsky_mosharov_banerjee_ataullakhanov_2000 @ v0.0.1

Martinov, Vitvitsky, Mosharov, Banerjee, Ataullakhanov, 2000

nothing

Parameters:

Name Description
V_MATIIImax 22870.0
Km2_MATIII 21.1
Ki_GNMT 20.0
V_MATImax 561.0
V_METmax 4544.0
Km_GNMT 4500.0
V_GNMTmax 10600.0
Km_MATI 41.0
alpha_d 1333.0
K_AHC 0.1
Ki_MATI 50.0
Km2_MET_A 10.0
Ado 1.0

States:

Name Description
AdoHcy(time) 3.0
AdoMet(time) 60.0

Observables: none

marwan_2003 @ v0.0.1

Marwan, 2003

nothing

Parameters:

Name Description
glucose 1.0
alpha2 50.0
alpha1 30.0
kia 0.1
kai 0.8
kd 0.1
Ifr_sigma_fr_phi_fr 0.1
kx 0.2
kG 0.1
ky 1.0
Ir_sigma_r_phi_r 0.0

States:

Name Description
Pr(time) 0.0
prepreS(time) 200.0
Pfr(time) 10.0
Ya(time) 0.9
V(time) 50.0
Xa(time) 0.0
S(time) 0.0
Xi(time) 6.0
preS(time) 0.0

Observables: none

matsuoka_sarai_kuratomi_ono_noma_2003 @ v0.0.1

Matsuoka, Sarai, Kuratomi, Ono, Noma, 2003

nothing

Parameters:

Name Description
Y_d 0.027
k_C_U 0.143
P_lCa 0.11
stim_start 50.0
T 310.0
P_Na 2860.0
P_Ks_Na 0.2016
P_NaCa 6.81
KForceEC 140000.0
L 0.9623799975411884
V_rel 160.0
Km_CaSR 0.08
Km_Ki 32.88
Km_Nai 8.75
B 1.2
k_C_CCa 6.954
P_Ks_K 5.04
k_CCa_UCa 0.0003
Ko 5.4
P_Cab 0.04
CMDN_max 0.05
P_KATP 0.0236
Cm 132.0
Z_2 0.0039
P_SR_T 386.0
k_AI_AP 8.75e-5
P_bNSC 0.385
P_NaK 21.0
h_c 0.005
beta_y2 0.004444
Y_4 0.12
Y_1 39.0
k3 1.0
k_UCa_CCa 0.35
Z_1 0.03
ZeroForceEL 0.97
Adenosine_Total 5.0
ProducingRate_Max 0.003
P_Kr 0.00864
Z_3 1560.0
ForceFactor 1.8e6
P_RyR 62000.0
k_CCa_C 0.0042
Km_ATP 0.1
KForceLinearEc 200.0
P_CaL 8712.0
stim_duration 2.0
P_SR_L 459.0
Y_3 0.03
Cao 1.8
P_to_K 0.033
k_U_UCa 6.954
Km_Cai 0.00138
Km_Ko 0.258
stim_period 400.0
stim_end 1.0e6
Km_Nao 87.5
Km_CaCyto 0.0008
k4 0.000849
N 2333.0
K_mCMDN 0.00238
K_mCSQN 0.8
L_a 1.17
Y_2 0.0039
Vi 8000.0
k_AP_AI 0.004
P_to_Na 0.00297
k_U_C 0.35
Nao 140.0
Km_Cao 1.38
Diadid_Factor -150.0
Partition 0.32
V_up 400.0
P_K1_0 1.146
k1 0.01
i_max 162500.0
stim_amplitude -4000.0
CSQN_max 10.0
P_CaT 612.0
T_t 0.07
R 8.3143
k2 0.04
F 96.4867

States:

Name Description
y2(time) 0.20443083454225305
Caup(time) 2.611712901567567
p_U(time) 0.17246483915629204
X(time) 0.9573749975411884
p_AP_CaL(time) 1.5445004166497696e-6
p_open_RyR(time) 0.00034314360001543243
p_close_RyR(time) 0.19135178123107768
y1(time) 1.6882718240109127e-5
y(time) 0.6080573900752752
Ca_Total(time) 9.455741736977666
pCaCB(time) 0.001990153835322864
p_AI_Na(time) 0.40285968661346977
ATPi(time) 4.657102729020499
y3(time) 0.967887666264921
p_RP_CaL(time) 0.9968480629364956
Nai(time) 4.925761439682025
p_AP_Na(time) 1.779648367445368e-5
p_UCa(time) 6.098246017787626e-5
pCB(time) 0.00042941813853474524
p_RP_Na(time) 0.3556412697995689
Ki(time) 143.1837333000449
p_C(time) 0.4250747299372254
Vm(time) -85.95752434460744
p_AI_CaL(time) 0.000877325391245903
pCa(time) 0.02490898775497523

Observables: none

maurya_bornheimer_venkatasubramanian_subramaniam_2005 @ v0.0.1

Maurya et al. 2005

nothing

Parameters:

Name Description
G_tot 1.0e-8
P_minus2 25.0
P_minus4 25.0
k1 529000.0
P_minus3 0.013
k2 1.28
P_minus1 0.013

States:

Name Description
Pi_(time) 0.0044
RG(time) 0.0
T(time) 0.000468
RGD(time) 0.0
GD(time) 1.0e-8
GAD(time) 0.0
GT(time) 0.0
RGT(time) 0.0
A(time) 0.0
G(time) 0.0
R(time) 0.0
GA(time) 0.0
RGAT(time) 0.0
RGA(time) 0.0
D(time) 0.000149
GAT(time) 0.0
RGAD(time) 0.0

Observables: none

mazhari_greenstein_winslow_marban_nuss_2001 @ v0.0.1

Mazhari, Greenstein, Winslow, Marban, Nuss, 2001

nothing

Parameters:

Name Description
Kb 0.1348
Kf 0.0266
Vm -80.0

States:

Name Description
O(time) nothing
I(time) nothing
C2(time) nothing
C1(time) nothing
C3(time) nothing

Observables: none

mcallister_noble_tsien_1975 @ v0.0.1

Mcallister, Noble, Tsien, 1975

nothing

Parameters:

Name Description
g_Clb 0.01
g_si 0.8
C 10.0
E_Cl -70.0
g_Na 150.0
g_Nab 0.105
E_K -110.0
g_qr 2.5
E_si 70.0
E_Na 40.0
E_K1 -30.0
g_si_ 0.04
E_s -52.0

States:

Name Description
d(time) 0.00293135
r(time) 0.13500116
V(time) -78.041367
h(time) 0.78656359
m(time) 0.02566853
x2(time) 0.0176854
s(time) 0.75473994
f(time) 0.80873917
x1(time) 0.02030289
q(time) 3.11285794

Observables: none

mckenzie_sneyd_1998 @ v0.0.1

Mckenzie, Sneyd, 1998

nothing

Parameters: none

States: none

Observables: none

mclean_su_vandenbogert_2003 @ v0.0.1

Mclean, Su, Vandenbogert, 2003

nothing

Parameters:

Name Description
g_max 1.5
L_CE_opt 0.01
W 0.63
A 0.25
L_slack 0.0025
k_SEE 1.0e6
a 0.8
S 2.0
F_max 7000.0
F_min 10.0
V_max 0.93
gamma 5.67

States:

Name Description
g_V_CE(time) nothing
L_CE(time) nothing

Observables: none

mears_sheppard_atwater_rojas_bertram_sherman_1997 @ v0.0.1

Mears 1997

nothing

Parameters:

Name Description
V_CRAC 0.0
sloper 3.0
f 0.01
kerp 0.09
dip3 0.2
sigma_er 1.0
g_K_Ca 1200.0
Vm_f -20.0
Vj -53.0
V_K -70.0
Sj 2.0
IP3 0.0
g_Ca_f 810.0
Vn -15.0
verp 0.24
Sm_s 10.0
lambda_n 1.85
lambda_er 250.0
Cm 6158.0
dinh 0.4
kmp 0.35
Vm_s -16.0
Sm_f 7.5
Ca_er_bar 40.0
Sn 6.0
g_K 3900.0
g_K_ATP 150.0
dact 0.35
perl 0.003
V_Ca 100.0
g_leak 0.0
gamma 3.607e-6
g_Ca_s 510.0
vmp 0.08
g_CRAC 75.0
kdkca 0.55

States:

Name Description
jm(time) 0.12
V(time) -61.0
n(time) 0.0005
Ca_i(time) 0.11
Ca_er(time) 60.0

Observables: none

Medrano_Gracia_PCA_2013 @ v0.0.1

Large Scale Left Ventricular Shape Atlas Using Automated Model Fitting to Contours

The model gives a statistical model of left ventricular cardiac shape (built using Principal Components Analysis). In this repository, the data has been converted into JSON format, and can be loaded into a WebGL based model visualiser.

Parameters: none

States: none

Observables: none

MetabolicComponentLibrary @ v0.0.1

Metabolic Component Library

Library of CellML metabolic components.

Parameters: none

States: none

Observables: none

michailova_mcculloch_2001 @ v0.0.1

Michailova, Mcculloch, 2001

nothing

Parameters:

Name Description
k_a_minus 576.0
K_mEGTA 0.00015
stim_start 0.1
k_minus_CaADP 193500.0
Vmaxr 0.318
tau_xfer_MgADP 0.0534
k_minus_MgATP 10875.0
omega 10.0
k_b_minus 1930.0
k_plus_CaATP 225000.0
V_NSR 2.1e-6
ADP_tot 0.005
K_mNa 87.5
eta 0.35
k_minus_MgADP 84500.0
LTRPN_tot 0.07
g_Ks 0.0027134
tau_tr 0.0005747
g_Kr 0.0034
K_mCa 1.38
k_a_plus 1.215e13
V_ss 1.2e-9
Na_o 138.0
fprime 7.0
v1 1800.0
b 2.0
g_Nab 0.0031
tau_xfer 0.0267
tau_xfer_MgATP 0.0534
MgATP_i0 2.888
tau_xfer_CaATP 0.0534
gprime 7000.0
k_ltrpn_minus 40.0
I_pCa 0.05
I_NaK 0.693
k_plus_MgATP 125000.0
CSQN_tot 15.0
N_rb 1.0
g_Kp 0.002216
stim_amplitude -100.0
m 3.0
F 96.4853415
n 4.0
f 300.0
K_mNa_i 10.0
T 310.0
C_sc 0.001
K_SR 1.0
i_Ca_half -0.265
k_htrpn_plus 20000.0
K_sat 0.2
K_mK1 13.0
tau_xfer_CaADP 0.0534
tau_xfer_Mg 0.0267
ATP_tot 7.0
k_htrpn_minus 0.066
g 2000.0
k_b_plus 4.05e9
k_c_plus 100.0
g_K1 2.8
V_myo 2.584e-5
k_c_minus 0.8
k_plus_MgADP 125000.0
EGTA_tot 0.0
stim_duration 0.0005
K_mK_o 1.5
Ca_o 2.0
K_mpCa 5.0e-5
a 2.0
tau_factor 1.0
stim_period 1.0
stim_end 1.0e8
V_JSR 1.6e-7
K_mCSQN 0.8
K_mCMDN 0.00238
K_o 4.0
K_fb 0.000168
k_minus_CaATP 45000.0
A_cap 0.0001534
k_ltrpn_plus 40000.0
CMDN_tot 0.05
N_fb 1.2
HTRPN_tot 0.14
g_to1 0.23815
P_Ca 0.0003125
g_Na 12.8
Vmaxf 0.0813
g_Cab 0.0003842
k_plus_CaADP 125000.0
K_rb 3.29
K_NaCa 0.3
R 8.314472
P_K 5.79e-7

States:

Name Description
Ca_NSR(time) 0.262
MgADP_i(time) 0.00298
C0(time) 0.997208
y(time) 0.798
C3(time) 1.63909e-14
HTRPNCa(time) 0.98
O(time) 9.84546e-21
C_Ca0(time) 0.00272826
CaADP_i(time) 1.1e-7
Mg_ss(time) 1.0
C_Ca3(time) 2.87031e-15
X_to1(time) 2.63
LTRPNCa(time) 0.078
X_ks(time) 0.264
V(time) -96.1638
C_Ca1(time) 6.99215e-7
C1(time) 6.38897e-5
O_Ca(time) 0.0
P_O2(time) 0.0
C_Ca2(time) 6.71989e-11
X_kr(time) 0.51
P_C1(time) 0.47
Ca_ss(time) 0.0001315
P_C2(time) 0.53
C2(time) 1.535e-9
CaATP_i(time) 0.000237
MgATP_ss(time) 6.4395
j(time) 0.99254
CaATP_ss(time) 0.00025
m(time) 0.0328302
C4(time) 6.56337e-20
Y_to1(time) 0.99
Na_i(time) 10.0
CaADP_ss(time) 1.3e-7
Mg_i(time) 1.0
MgATP_i(time) 6.4395
C_Ca4(time) 4.59752e-20
h(time) 0.988354
K_i(time) 159.48
P_O1(time) 0.0
Ca_JSR(time) 0.2616
MgADP_ss(time) 0.00298
Ca_i(time) 8.464e-5

Observables: none

michailova_saucerman_belik_mcculloch_2005 @ v0.0.1

Michailova 2005

nothing

Parameters:

Name Description
k_a_minus 576.0
K_mEGTA 0.00015
stim_start 0.1
k_minus_CaADP 193500.0
Vmaxr 0.318
tau_xfer_MgADP 0.0534
k_minus_MgATP 10875.0
omega 10.0
k_b_minus 1930.0
k_plus_CaATP 225000.0
V_NSR 2.1e-6
ADP_tot 0.005
gd 0.89
K_mNa 87.5
eta 0.35
k_minus_MgADP 84500.0
LTRPN_tot 0.07
g_Ks 0.0027134
tau_tr 0.0005747
g_Kr 0.0034
K_mCa 1.38
k_a_plus 1.215e13
V_ss 1.2e-9
Na_o 138.0
v1 1800.0
b 2.0
g_Nab 0.0031
tau_xfer 0.0267
tau_xfer_MgATP 0.0534
MgATP_i0 2.888
tau_xfer_CaATP 0.0534
k_ltrpn_minus 40.0
I_pCa 0.05
I_NaK 0.693
k_plus_MgATP 125000.0
k_MgATP_ss 1.4
CSQN_tot 15.0
N_rb 1.0
g_Kp 0.002216
stim_amplitude -100.0
m 3.0
K_o_normal 4.5
F 96.4853415
n 4.0
f 300.0
K_mNa_i 10.0
T 310.0
k_MgADP 0.4
C_sc 0.001
K_SR 1.0
k_htrpn_plus 20000.0
G_K_ATP 0.05
K_sat 0.2
K_mK1 13.0
p_prime_k 6.658e-7
tau_xfer_CaADP 0.0534
tau_xfer_Mg 0.0267
ATP_tot 7.0
k_htrpn_minus 0.066
g 2000.0
k_b_plus 4.05e9
k_c_plus 100.0
g_K1 2.8
V_myo 2.584e-5
k_c_minus 0.8
k_plus_MgADP 125000.0
EGTA_tot 0.0
stim_duration 0.0005
K_mK_o 1.5
Ca_o 2.0
K_mpCa 5.0e-5
a 2.0
tau_factor 1.0
stim_period 1.0
stim_end 1.0e8
V_JSR 1.6e-7
K_mCSQN 0.8
K_mCMDN 0.00238
K_o 4.0
K_fb 0.000168
k_minus_CaATP 45000.0
go 0.08
k_ltrpn_plus 40000.0
A_cap 0.0001534
CMDN_tot 0.05
N_fb 1.2
HTRPN_tot 0.14
g_to1 0.23815
P_Ca 0.0003594
g_Na 12.8
k_ATP 0.6
Vmaxf 0.0813
g_Cab 0.0003842
k_plus_CaADP 125000.0
K_rb 3.29
K_NaCa 0.3
R 8.314472

States:

Name Description
X_kr(time) 0.51
P_C1(time) 0.47
Ca_ss(time) 0.0001315
MgADP_i(time) 0.00298
P_C2(time) 0.53
v(time) 0.1
y(time) 0.798
Ca_NSR(time) 0.262
HTRPNCa(time) 0.98
CaATP_i(time) 0.000237
MgATP_ss(time) 6.4395
CaADP_i(time) 1.1e-7
Mg_ss(time) 1.0
CaATP_ss(time) 0.00025
j(time) 0.99254
X_to1(time) 2.63
m(time) 0.0328302
Y_to1(time) 0.99
w(time) 0.1
CaADP_ss(time) 1.3e-7
Mg_i(time) 1.0
MgATP_i(time) 6.4395
Na_i(time) 10.0
LTRPNCa(time) 0.078
X_ks(time) 0.264
V(time) -96.1638
h(time) 0.988354
z(time) 0.1
K_i(time) 159.48
P_O1(time) 0.0
Ca_JSR(time) 0.2616
MgADP_ss(time) 0.00298
P_O2(time) 0.0
Ca_i(time) 8.464e-5

Observables: none

miftakhov_abdusheva_christensen_1999 @ v0.0.1

Miftakhov, Abdusheva, Christensen, 1999

nothing

Parameters:

Name Description
E_Ca 80.0
K_c 0.00425
E_Cl -40.0
alpha 0.12
tau_x_Ca 500.0
g_Cl 0.003
rho 125.0
g_K 0.3
E_K -75.0
g_Ca_K 0.03
g_Ca_L 0.004
g_Ca_T 0.51
lamda 12.5
Cm 2.5

States:

Name Description
V(time) -55.0
n(time) 0.01
h(time) 0.01
x_Ca(time) 0.01
Ca(time) 0.0001

Observables: none

mijailovich_butler_fredburg_2000 @ v0.0.1

Mijailovich, Butler, Fredburg, 2000

nothing

Parameters:

Name Description
fp 0.44
gp 0.11
gp1 0.22
fp1 0.88
gx 0.11
k5 0.1
k2 0.1
g1 0.01

States:

Name Description
AMp(time) 0.0
Mp(time) 0.0
M(time) 1.0
AM(time) 0.0

Observables: none

mikane_araki_kohno_nakayama_suzuki_shimuzi_matsubara_hirakawa_takaki_suga_1997 @ v0.0.1

Mikane, Araki, Kohno, Nakayama, Suzuki, Shimuzi, Matsubara, Hirakawa, Takaki, Suga, 1997

nothing

Parameters:

Name Description
Ca_tot_released 35.0
f 400000.0
total_CB 150.0
g 10.0
total_Tn 70.0
k_2 10.0
k_3 1000.0
k_1 5.0e6

States:

Name Description
TnCa_t(time) 0.0
cumCB_off_t(time) 0.0
Ca_released(time) 0.0
Ca_t(time) 0.0
CB_on_t(time) 0.0
Ca_sequestered(time) 0.0
cumCB_on_t(time) 0.0

Observables: none

mitchell_schaeffer_2003 @ v0.0.1

Mitchell, Schaeffer, 2003

nothing

Parameters:

Name Description
tau_out 6.0
IstimPeriod 500.0
IstimAmplitude 0.2
tau_in 0.3
IstimPulseDuration 1.0
tau_open 120.0
tau_close 150.0
V_gate 0.13
IstimStart 0.0
IstimEnd 50000.0

States:

Name Description
Vm(time) 8.20413566106744e-6
h(time) 0.8789655121804799

Observables: none

mittler_sulzer_neumann_perelson_1998 @ v0.0.1

Mittler, Sulzer, Neumann, Perelson, 1998

nothing

Parameters:

Name Description
p 774.0
tau_p 0.0
c 3.0
VI_0 200000.0
m 0.01
k 2.4e-5
b 0.25
delta 0.5
n 4.0

States:

Name Description
VNI(time) 0.0
VI(time) 200000.0
E2(time) 0.0
I(time) 0.1
E3(time) 0.0
E4(time) 0.0
E1(time) 0.0

Observables: none

mlcek_neumann_kittnar_novak_2001 @ v0.0.1

Mlcek, Neumann, Kittnar, Novak, 2001

nothing

Parameters: none

States: none

Observables: none

modularmassactionprimer @ v0.0.1

A Primer on Modular Mass Action Modelling with CellML

Example code for the book chapter 'A Primer on Modular Mass Action Modelling with CellML'. Please select one of the Exposures below to access the code.

Parameters: none

States: none

Observables: none

mohr_taylor_newell_2008 @ v0.0.1

Mohr, Taylor, Newell, 2008

nothing

Parameters: none

States: none

Observables: none

morris_lecar_1981 @ v0.0.1

Morris and Lecar 1981

nothing

Parameters:

Name Description
i_app 300.0
V3 -1.0
E_L -50.0
E_Ca 100.0
C 20.0
g_L 2.0
V4 14.5
lambda_n_bar 0.066666667
lambda_m_bar 1.0
V1 10.0
g_K 8.0
E_K -70.0
V2 15.0
g_Ca 4.0

States:

Name Description
V(time) -50.0
n(time) 0.001
m(time) 0.1

Observables: none

mosekilde_lading_yanchuk_maistrenko_2001 @ v0.0.1

Mosekilde, Lading, Yanchuk, Maistrenko, 2001

nothing

Parameters: none

States: none

Observables: none

moss_kazmierczak_kirley_harris_2009 @ v0.0.1

Moss, Kazmierczak, Kirley, Harris, 2009

nothing

Parameters: none

States: none

Observables: none

muller_obeyesekere_mills_ram_2008 @ v0.0.1

Muller, Obeyesekere, Mills, Ram, 2008

nothing

Parameters:

Name Description
b1 10.0
f24 0.8
f13 0.6
f35 0.3
a1 10.0
a2 10.0
b2 10.0
d1 0.2
E 10.0
f14 0.1
f53 1.5
f45 0.1
d5 1.0
h36 0.1
d3 1.0
d6 0.001
d4 1.1
d2 0.1

States:

Name Description
y2(time) 0.0
y3(time) 0.0
y1(time) 0.0
y4(time) 0.0
y5(time) 0.0
y6(time) 0.0

Observables: none

Myocardial_contractility_and_regional_work @ v0.0.1

Myocardial contractility and regional work throughout the cardiac cycle using FEM and MRI

nothing

Parameters: none

States: none

Observables: none

N


nagano_gerritsen_2001 @ v0.0.1

Nagano and Gerritsen, 2001

nothing

Parameters:

Name Description
slope 2.0
alpha 1449.027
L_slack 0.42
B_REL 5.2
width 0.888
A_REL 0.41
F_max 3277.4
Factor 1.0
F_asympt 1.5
L_ce_opt 0.055
q 1.0

States:

Name Description
L_ce(time) 0.05

Observables: none

nagerl_novo_mody_vergara_2000 @ v0.0.1

Nagerl, Novo, Mody, Vergara, 2000

nothing

Parameters:

Name Description
koff_D nothing
Ca_T nothing
kon_D nothing
alpha nothing
D_T nothing
kon_Bi nothing
kon_DM nothing
Bi nothing
koff_DM nothing
DM_T nothing
koff_Bi nothing
koff_DM_ nothing
tau_photolysis nothing
t_pulse nothing

States:

Name Description
CaD(time) nothing
CaDM2(time) nothing
CaDM1(time) nothing
CaBi(time) nothing

Observables: none

nash_panfilov_2004 @ v0.0.1

Nash, Panfilov, 2004

nothing

Parameters: none

States: none

Observables: none

nazaret_heiske_thurley_mazat_2009 @ v0.0.1

Nazaret, Heiske, Thurley and Mazat, 2009

nothing

Parameters: none

States: none

Observables: none

nelson_murray_perelson_2000 @ v0.0.1

Nelson, Murray, Perelson, 2000

nothing

Parameters:

Name Description
delta_1 0.03
c 3.0
m 0.01
np 1.0
N 480.0
k 3.43e-5
lambda 5.0
tau 1.0
delta 0.5

States:

Name Description
VNI(time) 0.0
VI(time) 134000.0
T(time) 180.0
T_star(time) 3.6

Observables: none

nelson_perelson_1995 @ v0.0.1

Nelson, Perelson 1995

nothing

Parameters:

Name Description
N_0 300.0
k_1 2.4e-5
s_0 10.0
T_max 1500.0
k_1_ 2.4e-7
r 0.03
k_s 0.48
mu_TD 0.02
t_c 7305.0
mu_V 2.4
mu_b 0.24
D_0 0.1
theta 1.0
mu_T 0.02
mu_D 0.76
mu_bD 0.12
k_2 0.017
gamma 25.0
t_DIV 2557.0
k_1D 2.4e-5

States:

Name Description
T_D2(time) 0.0
T_2(time) 0.0
V_(time) 0.0
V(time) 0.001
T(time) 1000.0
T_1(time) 0.0
D(time) 0.0
T_D1(time) 0.0
D_ode(time) 0.0

Observables: none

neumann_lam_dahari_gretch_wiley_layden_perelson_1998 @ v0.0.1

Neumann, Lam, Dahari, Gretch, Wiley, Layden, Perelson, 1998

nothing

Parameters:

Name Description
delta 0.5
beta 3.0e-7
c 5.0
epsilon 0.99
eta 0.8
s 10.0
p 100.0
d 0.02

States:

Name Description
V(time) 9.4e6
I(time) 0.0
T(time) 1000.0

Observables: none

nevo_golding_neumann_schwartz_akselrod_2004 @ v0.0.1

Nevo, Golding, Neumann, Schwartz, Akselrod, 2004

nothing

Parameters: none

States: none

Observables: none

niederer_hunter_smith_2006 @ v0.0.1

Niederer, Hunter, Smith, 2006

nothing

Parameters:

Name Description
T_ref 56.2
Ca_50ref 0.00105
n_Hill 3.0
z_p 0.85
A_1 -29.0
a 0.35
K_z 0.15
alpha_2 0.13
alpha_r1 0.002
A_2 138.0
beta_0 4.9
k_on 100.0
k_Ref_off 0.2
alpha_3 0.625
n_Rel 3.0
Ca_TRPN_Max 0.07
alpha_r2 0.00175
gamma_trpn 2.0
alpha_1 0.03
beta_1 -4.0
A_3 129.0
alpha_0 0.008

States:

Name Description
Q_2(time) 0.0
Q_3(time) 0.0
TRPN(time) 0.067593139865
z(time) 0.014417937837
Q_1(time) 0.0

Observables: none

niederer_smith_2007 @ v0.0.1

Niederer, Smith, 2007

nothing

Parameters:

Name Description
KA 21.4935205515214
kp1 4677.0
Cle 126.0
PP_co2e 0.05
g_Cl 2.0e-5
Ae 140.0
B_CMDN 0.05
K_CMDN 0.00238
scale_K 0.0
alpha_2 0.13
k_on 100.0
d 100.0
Na_e 140.0
J_CO2 0.0
theta_R 0.012
g_H 4.0e-6
K_HCO3 0.008017
k_sat 0.1
K_mNa 87.5
eta 0.35
delta_VL 7.0
J_R 2.0e-11
Nae 140.0
K_mCa 1.38
ib1 31.2044223705215
A_3 129.0
alpha_0 0.008
g_SAC 4.1333e-7
kr_co2hyd 0.481
a_endo 0.583
Na_o 140.0
Ca_50ref 0.00105
pKa_ib2 7.48048792987277
n_Hill 3.0
km1 777.92
b 14.0
g_ss 7.0e-6
K_z 0.15
V_SR 2.098e-6
g_pCa 3.5e-6
g_D 6.5e-11
b_endo 0.417
alpha_r1 0.002
P_atm 760.0
f_Na 0.2
g_NCX 0.0385
K_m_Na 10.0
n_Rel 3.0
g_t 3.5e-5
n_Hi 2.91
pH_scale 1.0
gamma_trpn 2.0
g_f 1.45e-6
K_Cl 983.5
stim_amplitude -0.0006
tau_L 650.0
Pco2 5.8e-5
phi_L 2.35
K_RyR 0.041
NO_on 0.0
g_SRl 5.2e-6
kf_co2hyd 0.000365
kp2 6.656
F 96487.0
ib2 6.84513535697271
T 295.0
c 0.01
K_m_K 1.5
A_1 -29.0
phi_R_base 0.05
pKa_ib1 6.40013149605198
K_He 6.53e-5
i_NaK_max 9.5e-5
K_L 0.00022
g_B_K 1.38e-7
g_Ko 1.2e-6
Q_10Scaler 0.35
alpha_r2 0.00175
J_L 9.13e-13
V_myo 2.584e-5
g_K1 2.4e-5
KB 1.77948608115949e-7
K_Hi 0.000183
CO_2sol 0.03253
tau_R 2.43
CmF 0.0001
SAC_on 0.0
E_R -10.0
T_ref 56.2
stim_duration 10.0
V_L0 -2.0
z_p 0.85
B_TRPN 0.07
Ca_o 2.0
g_B_Na 8.015e-8
K_mpCa 0.0005
a 0.35
Ca_e 2.0
delta 0.075
stim_period 1000.0
pH_e 7.4
ExtensionRatio 1.0
N 75000.0
K_o 5.4
TRPN_tot 0.07
A_cap 0.01534
beta_0 4.9
A_2 138.0
pH_on 0.0
K_SERCA 0.0005
alpha_3 0.625
g_SERCA 0.00045
g_Na 0.0008
alpha_1 0.03
K_Na 4866.11
g_Cab 2.4216e-8
beta_1 -4.0
k_off 0.2
scale_Na 0.0
n_He 2.18
t_L 1.0
R 8314.5
K_OH 0.0008907

States:

Name Description
z_1(time) 0.988955429362334
y(time) 0.00331726547133295
z_2(time) 0.00860686643357905
s_slow(time) 0.530207467628341
j(time) 0.675294627571238
Q_3(time) 0.0
z_3(time) 0.00241692704700704
m(time) 0.00419283833975832
s(time) 0.922573773425153
Na_i(time) 10.9735342589175
HCO3i(time) 15.1428688811927
TRPN(time) 0.0670845085340179
V(time) -80.5561112771341
Cli(time) 16.2285651746901
h(time) 0.675647510010602
r_ss(time) 0.00289374682707489
z(time) 0.0175189833295748
K_i(time) 142.021261491871
s_ss(time) 0.308572839431787
Q_2(time) 0.0
r(time) 0.00218107055088884
CO2i(time) 1.23610845162584
Ca_SR(time) 0.843733859307907
Ca_i(time) 8.60587059887361e-5
pH_i(time) 7.20905044774657
Q_1(time) 0.0

Observables: none

noble_1962 @ v0.0.1

Noble, 1962

nothing

Parameters:

Name Description
E_L -60.0
g_L 75.0
E_Na 40.0
g_Na_max 400000.0
Cm 12.0

States:

Name Description
V(time) -87.0
h(time) 0.8
m(time) 0.01
n(time) 0.01

Observables: none

noble_2000 @ v0.0.1

Noble, 2000

nothing

Parameters:

Name Description
T 310.0
stim_start 200.0
g_Kr2 0.0017
P_kna 0.03
alpha_Calmod 100000.0
g_bca 0.00025
alpha_Trop 100000.0
length 74.0
d_NaCa 0.0
K_leak_rate 0.05
alpha_up 0.4
i_NaK_max 0.7
g_to 0.005
delta_f 0.0001
Trop 0.05
Cm 9.5e-5
beta_up 0.03
FRiNaCa 0.001
g_Kr1 0.0028
FrICa 0.7
K_cyca 0.0003
beta_Trop 200.0
K_mNa 40.0
g_bna 0.0006
g_Ks 0.0016
g_K1 0.5
delta_m 1.0e-5
P_Ca_L 1.0
KCaChoff 0.01
K_srca 0.5
V_e_ratio 0.4
Na_o 140.0
V_ds_ratio 0.1
stim_duration 0.002
speed_d 3.0
Kdecay 10.0
K_m_rel 250.0
g_tos 0.0
n_NaCa 3.0
Kmdsinact 0.001
Ca_o 2.0
shift_h 0.0
V_up_ratio 0.01
stim_period 1.0
stim_end 600.0
K_mk1 10.0
K_m_Ca_ds 0.01
Calmod 0.02
radius 12.0
beta_Calmod 50.0
K_o 4.0
K_m_Ca_cyt 0.0005
K_xcs 0.4
V_rel_ratio 0.1
P_CaK 0.002
K_mK 1.0
g_Na 0.5
speed_f 0.3
g_pna 0.0027
stim_amplitude -6.0
P_CaNa 0.01
gamma 0.2
k_NaCa 0.0005
R 8314.472
F 96485.3415

States:

Name Description
d(time) 0.0
Ca_Trop(time) 0.0003732
xr2(time) 2.0e-7
Ca_rel(time) 0.6460487
V(time) -92.8915042
h(time) 0.9944559
xs(time) 0.0006469
f(time) 0.0
K_i(time) 136.1745362
ProdFrac(time) 0.6950649
ActFrac(time) 0.0049039
Ca_ds(time) 2.7e-6
r(time) 0.0
m(time) 0.0016111
xr1(time) 1.02e-5
Ca_i(time) 1.49e-5
s(time) 0.9948645
Ca_up(time) 0.36963
Na_i(time) 7.6713487
Ca_Calmod(time) 0.0005841

Observables: none

noble_difrancesco_denyer_1989 @ v0.0.1

Noble, Difrancesco, Denyer, 1989

nothing

Parameters:

Name Description
tau_rel 0.01
V_e_ratio 0.1
T 310.0
C 6.0e-5
I_p 0.45
n_NaCa 3.0
Cao 2.0
Ca_up_max 5.0
g_Nab 0.0007
Km_f 45.0
K_mf2 0.0005
length 0.11
d_NaCa 0.0001
radius 0.008
g_f_K 0.06
delta_f 0.0001
speed_y 2.0
Km_K1 10.0
delta_d 0.0001
Nao 140.0
alpha_f2 10.0
K_mK 1.0
tau_rep 0.2
P_si 0.12
g_Na 0.0125
tau_up 0.005
rCa 2.0
K_mNa 40.0
g_Cab 0.0001
g_f_Na 0.06
g_K1 0.0075
delta_m 1.0e-5
i_K_max 0.8
gamma 0.5
K_NaCa 2.0e-5
K_mCa 0.002
R 8314.472
F 96485.3415
Kc 3.0

States:

Name Description
d(time) 1.26333192869164e-5
Ca_rel(time) 0.177741556496929
V(time) -67.797059970601
h(time) 0.138105285882671
f2(time) 0.485471180273736
x(time) 0.129303443591363
f(time) 0.999507224159629
y(time) 0.0743464067197738
Ki(time) 139.859968229045
p(time) 0.176207580044253
m(time) 0.042697621819783
Ca_up(time) 3.70806465918854
Cai(time) 5.84191784887783e-5
Nai(time) 7.51007221193712

Observables: none

noble_noble_1984 @ v0.0.1

Noble, Noble, 1984

nothing

Parameters:

Name Description
T 310.0
C 0.006
Ca_up_max 5.0
length 0.08
d_NaCa 0.0001
g_f_K 6.0
Kb 3.0
delta_f 0.0001
delta_x 0.0001
Km_K1 10.0
tau_rep 0.2
tau_up 0.005
K_mNa 40.0
g_K1 0.75
delta_m 1.0e-5
delta_y 1.0e-5
K_mCa 0.002
tau_rel 0.01
V_e_ratio 0.1
I_p 50.0
Cao 2.0
n_NaCa 3.0
g_Nab 0.07
K_mf2 0.0005
Km_f 45.0
radius 0.08
speed_y 2.0
delta_d 0.0001
Nao 140.0
alpha_f2 10.0
K_mK 1.0
rCa 2.0
P_si 7.5
g_Na 1.25
g_Cab 0.01
g_f_Na 6.0
i_K_max 20.0
gamma 0.5
K_NaCa 0.002
R 8314.472
V_e 0.00016077
pf 1.0
F 96485.3415

States:

Name Description
d(time) 0.0011
Ca_rel(time) 0.55
V(time) -60.0
h(time) 0.015
f2(time) 0.785
x(time) 0.54
f(time) 0.785
y(time) 0.007
Kc(time) 3.0
Ki(time) 140.0
p(time) 0.785
m(time) 0.076
Ca_up(time) 1.98
Cai(time) 5.8e-5
Nai(time) 7.5

Observables: none

noble_noble_2001 @ v0.0.1

Noble, Noble, 2001

nothing

Parameters:

Name Description
T 310.0
stim_start 0.1
g_Kr2 0.0017
P_kna 0.03
alpha_Calmod 100000.0
g_bca 0.00025
alpha_Trop 100000.0
length 74.0
d_NaCa 0.0
K_leak_rate 0.05
alpha_up 0.4
i_NaK_max 0.7
g_to 0.005
delta_f 0.0001
Trop 0.05
Cm 9.5e-5
beta_up 0.03
FRiNaCa 0.001
g_Kr1 0.0028
FrICa 0.7
K_cyca 0.0003
beta_Trop 200.0
K_mNa 40.0
g_bna 0.0006
g_Ks 0.0016
g_K1 0.5
delta_m 1.0e-5
P_Ca_L 1.0
KCaChoff 0.01
K_srca 0.5
V_e_ratio 0.4
Na_o 140.0
V_ds_ratio 0.1
stim_duration 0.002
speed_d 3.0
Kdecay 10.0
K_m_rel 250.0
g_tos 0.0
n_NaCa 3.0
Kmdsinact 0.001
Ca_o 2.0
shift_h 0.0
V_up_ratio 0.01
stim_period 1.0
stim_end 600.0
K_mk1 10.0
K_m_Ca_ds 0.01
Calmod 0.02
radius 12.0
beta_Calmod 50.0
K_o 4.0
K_m_Ca_cyt 0.0005
K_xcs 0.4
V_rel_ratio 0.1
P_CaK 0.002
K_mK 1.0
g_Na 0.5
speed_f 0.3
g_pna 0.0027
stim_amplitude -6.0
P_CaNa 0.01
gamma 0.2
k_NaCa 0.0005
R 8314.472
F 96485.3415

States:

Name Description
d(time) 2.27643784381792e-8
Ca_Trop(time) 0.00013982468565579
xr2(time) 2.15138346929839e-7
Ca_rel(time) 0.185609773872992
V(time) -93.0550060340878
h(time) 0.99465397024286
xs(time) 6.72192033116639e-7
f(time) 4.03082807230434e-9
K_i(time) 138.49601832864
ProdFrac(time) 0.0109931117325847
ActFrac(time) 0.000183030061767109
Ca_ds(time) 2.15623822848619e-7
r(time) 1.8398417043009e-8
m(time) 0.00157541794600382
xr1(time) 9.88715446781661e-6
Ca_i(time) 5.60867201979414e-6
s(time) 0.999870016703514
Ca_up(time) 0.187470810108547
Na_i(time) 5.68929064089788
Ca_Calmod(time) 0.000221858224298955

Observables: none

noble_noble_bett_earm_ho_so_1991 @ v0.0.1

Noble, Noble, Bett, Earm, Ho, So, 1991

nothing

Parameters:

Name Description
T 310.0
stim_start 0.1
alpha_Calmod 100000.0
g_bca 0.00025
alpha_Trop 100000.0
length 0.074
d_NaCa 0.0
K_leak_rate 0.0
alpha_up 0.4
i_NaK_max 0.7
g_to 0.005
delta_f 0.0001
Trop 0.05
Cm 9.5e-5
beta_up 0.03
K_m_Ca 0.0005
K_cyca 0.0003
beta_Trop 200.0
K_mNa 40.0
g_bna 0.0006
g_K1 1.0
delta_m 1.0e-5
P_Ca_L 0.25
K_srca 0.5
V_e_ratio 0.4
Na_o 140.0
stim_duration 0.002
g_tos 0.0
speed_d 3.0
K_m_rel 250.0
n_NaCa 3.0
Ca_o 2.0
shift_h 0.0
V_up_ratio 0.01
stim_period 1.0
stim_end 100.0
K_mk1 10.0
Calmod 0.02
radius 0.012
beta_Calmod 50.0
K_o 4.0
g_bk 0.0006
K_xcs 0.4
V_rel_ratio 0.1
P_CaK 0.002
K_mK 1.0
g_Na 2.5
speed_f 0.5
stim_amplitude -6.0
i_K_max 1.0
P_CaNa 0.01
gamma 0.5
k_NaCa 0.0005
R 8314.472
F 96485.3415

States:

Name Description
d(time) 1.91821833548952e-8
Ca_Trop(time) 0.00033477224086766
Ca_rel(time) 0.591323137897127
V(time) -93.7400119196694
h(time) 0.995414125415674
x(time) 0.00938586574433011
f(time) 0.999999956287155
K_i(time) 136.604284305878
ActFrac(time) 0.00267040300939318
ProdFrac(time) 0.522949441962453
r(time) 1.60424507876553e-8
m(time) 0.00143405969732302
Ca_up(time) 0.59333810408885
Ca_i(time) 1.34858164771406e-5
s(time) 0.997644968939185
Na_i(time) 7.50547214142684
Ca_Calmod(time) 0.000524570960945961

Observables: none

noble_varghese_kohl_noble_1998 @ v0.0.1

Noble, Varghese, Kohl, Noble, 1998

nothing

Parameters:

Name Description
stim_start 0.1
cross_bridge_density 0.05
gama_SAC_IT 2.5
ITHST 1.0
K_D 0.00013
g_Ca_stretch 0.01
length 74.0
alpha_Trop 100000.0
d_NaCa 0.0
sarcomere_length 2.0
Km_f2ds 0.001
delta_f 0.0001
E_fibro_stretch 0.0
g_Na_stretch 0.01
g_Kr1 0.0021
KCont2 100.0
g_fibro 0.0002
K_cyca 0.0003
beta_Trop 200.0
K_mNa 40.0
g_bna 0.0006
g_K_ATP 0.0
g_Ks 0.0026
gama_SAC_SL 2.5
P_Ca_L 0.1
g_An_stretch 0.01
alpha_ACh 0.5
K_srca 0.5
ACh 5.0
Na_o 140.0
V_ds_ratio 0.1
speed_d 3.0
Kdecay 10.0
K_m_rel 250.0
shift_h 0.0
KCont1 12000.0
g_K_stretch 0.01
gama_SR_SL 2.5
K_m_Ca_ds 0.01
radius 12.0
SLHST 2.0
K_m_Ca_cyt 0.0005
K_xcs 0.4
P_CaK 0.002
K_mK 1.0
speed_f 0.3
g_KACh 0.0
KCont4 25.0
stim_amplitude -3.0
KCont3 60.0
K_ATP 0.1
Km_f2 100000.0
P_CaNa 0.01
c_fibro 1.0e-5
gama_SR_IT 2.5
F 96485.3415
T 310.0
g_Kr2 0.0013
P_kna 0.03
alpha_Calmod 100000.0
g_bca 0.00025
g_fibro_stretch 0.0
K_leak_rate 0.005
alpha_up 0.4
i_NaK_max 0.7
g_to 0.005
Trop 0.05
Cm 9.5e-5
beta_ACh 0.5
beta_up 0.03
FRiNaCa 0.001
shiftK1 10.0
K_kna 20.0
FrICa 1.0
g_K1 0.5
KTrop 5000.0
delta_m 1.0e-5
V_e_ratio 0.4
ATP 0.0
stim_duration 0.003
g_tos 0.0
steepK1 1.25
n_NaCa 3.0
g_K_Na 0.0
Ca_o 2.0
R_decay 20.0
V_up_ratio 0.01
stim_period 1.0
stim_end 10000.0
K_mk1 10.0
g_fibro_junct 0.00029
Calmod 0.02
beta_Calmod 50.0
K_o 4.0
gama_Trop_SL 1.5
E_An_stretch -20.0
V_rel_ratio 0.1
g_Na 2.5
g_pna 0.004
gamma 0.5
k_NaCa 0.0005
R 8314.472

States:

Name Description
V_fibro(time) -20.0
x_ACh(time) 0.0
xs(time) 0.001302
f(time) 1.0
ProdFrac(time) 0.2854569
ActFrac(time) 0.001914
m(time) 0.0016203
s(time) 0.9948645
Na_i(time) 7.3321223
Ca_Calmod(time) 0.0005555
d(time) 0.0
Ca_Trop(time) 0.0002
xr2(time) 2.0e-7
Ca_rel(time) 0.4481927
V(time) -92.849333
f2(time) 0.9349197
h(time) 0.9944036
K_i(time) 136.5644281
cross_bridge(time) 8.09e-5
Ca_ds(time) 1.88e-5
r(time) 0.0
xr1(time) 1.03e-5
Ca_i(time) 1.4e-5
Ca_up(time) 0.4531889
f2ds(time) 0.9651958
light_chain(time) 3.32e-5

Observables: none

novak_csikasznagy_gyorffy_chen_tyson_1998 @ v0.0.1

Novak, Csikasznagy, Gyorffy, Chen, Tyson, 1998

nothing

Parameters:

Name Description
Vwee 0.01
kaa_ 1.0
k25 0.5
V2_ 1.0
V25_ 0.4
kir 1.0
k25r_ 0.2
kad 0.1
Jmr 0.2
Vmik 0.002
k4_ 0.15
kai_ 0.25
kapr_ 3.0
kapr 0.04
Japr 0.01
k3 0.15
km 0.1
kap 4.0
kwr_ 0.2
kmr_ 0.0
Vwee_ 0.93
Jm 0.2
J25r 0.2
V2c 0.03
mu 0.005776
Jaa 0.1
V2 0.03
ki 200.0
kx 0.0
Vmik_ 0.2
J25 0.2
alpha 0.1
V2c_ 0.16
Puc1 0.013
kaa 0.001
k4__ 20.0
Jap 0.01
k1 0.03
Jw 0.2
kw 0.5
Jwr 0.2
kas 0.25
Jai 0.1
V25 0.01

States:

Name Description
APC(time) 0.0
Mik1(time) 0.0